Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…The discussion would focus on the molecular pathways that control autophagy in brain tumors, and its dual role as a tumor suppressor and a supporter of tumor survival. …”
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The Role of Oxidative Stress in the Aging Process by Barbara F. Oliveira, José Augusto Nogueira-Machado, Míriam M. Chaves

“…ROS/RNS are known to play a dual role in biological systems since they can be either harmful or beneficial to living systems.…”
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Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia by Elissa Tjahjono, Megan R. Daneman, Bernadetta Meika, Alexey V. Revtovich, Natalia V. Kirienko

“…This review discusses the dual role mitophagy plays in AML survival, the importance of targeting mitophagy to treat AML, and current progress in the area. …”
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INNOVATIVE INFORMATION TECHNOLOGIES IN ELECTION POLITICAL COMMUNICATIONS by Анна РУДНЄВА

“…By analyzing various tools, practices, and case studies, the article underscores the dual role of innovative information technologies in electoral communications: as catalysts for engagement and as potential vectors for manipulation. …”
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BIOMARKERS, NEOANGIOGENESIS AND GROWTH FACTORS IN PANCREATIC CANCER by E. M. Frantsiyants, O. I. Kit, V. I. Aleynov, I. A. Goroshinskaya

“…In this review, we also highlight the dual role of growth factor-β (TGF-β) and touch upon the prospects for therapeutic effects on targets associated with TGF-β signaling in pancreatic cancer. …”
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Savoring the past, preserving the future: a mixed-methods examination of culinary traditions among Pontic Greeks in Northern Greece by Achillefs Keramaris, Eleni Kasapidou, Paraskevi Mitlianga

“…Qualitative findings underscored the deep cultural and emotional significance of these foods, revealing themes such as intergenerational knowledge transmission, urbanization’s impact, and the dual role of heritage and convenience in shaping food choices. …”
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Exploring the Characteristics of Modern Korean Buddhist Education: Focusing on the Religious Studies Lecture Notes from the Buddhist Central Seminary (<i>Pulgyo Chungang Hangnim</i... by Eunyoung Kim

“…The seminary played a dual role as a hub for national education and reflection of the colonial context, embodying the complexities of nationalism and colonial influence during Japanese occupation. …”
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The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

“…Microglia, the innate immune cells of the CNS, contribute to neuroinflammation, glutamate excitotoxicity, and the balance between excitatory and inhibitory neurotransmission, underscoring their dual role in seizure promotion and protection. Meanwhile, oligodendrocytes, primarily involved in myelination, also modulate axonal excitability and contribute to the neuron–glia network underlying seizure pathogenesis. …”
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THE ENIGMA OF WORKING MOTHERS IN INSTITUTIONS OF HIGHER LEARNING IN NSUKKA L.G.A. OF ENUGU STATE: WORK-FAMILY ROLE CONFLICT by NDUBUISI ONESIMUS OPARAOCHA

“…The results showed coping strategies for working mothers, factors that help working mothers in their dual role functionalities. The result iterates psychological effects of role conflict on working mothers. …”
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Exploring the impact of entrepreneurial orientation and market orientation on entrepreneurial performance in the context of environmental uncertainty by Peng Cheng, Shaoling Wu, Juntao Xiao

“…Environmental uncertainty plays a dual role in this process by enhancing the positive effects of entrepreneurial orientation on market orientation and entrepreneurial performance, while weakening the direct effect of market orientation on entrepreneurial performance. …”
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Nesfatin-1 as a crucial mediator of glucose homeostasis in the reptile, Hemidactylus flaviviridis by Krittika Dotania, Mamta Tripathy, Umesh Rai

“…Therefore, present study elucidates role of nesfatin-1 in glucose homeostasis in wall lizard wherein fasting stimulated hepatic nucb2/nesfatin-1, glycogen phosphorylase (glyp), phosphoenolpyruvate carboxykinase (pepck), and fructose 1,6-bisphosphatase (fbp), while feeding upregulated pancreatic nucb2/nesfatin-1 and insulin, suggesting towards tissue-specific dual role of nesfatin-1 in glucoregulation. The glycogenolytic/gluconeogenic role of nesfatin-1 was further confirmed by an increase in media glucose levels along with heightened hepatic pepck and fbp expression and concomitant decline in liver glycogen content in nesfatin-1-treated liver of wall lizard. …”
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The Role of Macrophages in the Pathogenesis of ALI/ARDS by Xiaofang Huang, Huiqing Xiu, Shufang Zhang, Gensheng Zhang

“…Notably, macrophages play a dual role of proinflammation and anti-inflammation based on the microenvironment in different pathological stages. …”
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Social media for public participation in urban planning in China based on place attachment-- a case of the Guangzhou banyan tree incident by Yifei Ouyang, Yifei Ouyang, Xiaohe Bai

“…Social media plays a dual role in this process. On one hand, it can improve the effectiveness of public participation in urban planning and ultimately fulfil the role of advancing democratic government decision-making. …”
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Court costs as an element of the mechanism of ensuring access to justice by M. V. Haidar, O. M. Shumilo

“…Authors highlight the multifaceted nature of court costs, emphasizing their dual role: on the one hand, they are essential for maintaining the financial sustainability of judicial systems; on the other, they can impede individuals' ability to seek justice. …”
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Early growth response 1 transcription factor and its context-dependent functions in glioblastoma by Saleh Rasras, Esma’il Akade, Seyed Ehsan Mohammadianinejad, Maedeh Barahman, Mohammad Bahadoram

“…Current evidence suggest that early growth response 1 (EGR1) plays a dual role as both an oncogene and a tumour suppressor in glioblastoma. …”
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The role of artificial intelligence in recruitment: Examining candidate experience as a mediator and organizational culture as a moderator in quality of hires by Jamaluddin, Roslina Alam, Niniek Lantara, Andi Rosdianti Razak, St Hatidja

“…Trust in AI is found to play a dual role, both directly influencing candidate experience and quality of hires and moderating the relationship between AI implementation and candidate experience. …”
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Cellular senescence: from homeostasis to pathological implications and therapeutic strategies by Chunhong Li, Yixiao Yuan, YingDong Jia, Qiang Zhou, Qiang Wang, Xiulin Jiang

“…Notably, this review also delves into the complex interactions between senescence and cancer, emphasizing the dual role of the senescent microenvironment in tumor initiation, progression, and treatment. …”
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Pathogenic and therapeutic roles of extracellular vesicles in sepsis by Benshuai You, Yang Yang, Jing Wei, Chenglin Zhou, Surong Dong

“…In this review, we discuss the dual role of EVs in the progression and treatment of sepsis, exploring their intricate involvement in both inflammation and tissue repair processes. …”
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Resolving the Commitment Conflict of TeacherAcademic Entrepreneurship in Research Universities in the United States by YAO Lin, LI Ting, DENG Yanhong

“…However, teachers play a dual role as scholars and entrepreneurs in the process of academic entrepreneurship. …”
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Beyond Needles: Immunomodulatory Hydrogel-Guided Vaccine Delivery Systems by Md Mohosin Rana, Cigdem Demirkaya, Hector De la Hoz Siegler

“…This review examines the potential of hydrogel-based systems to improve immunogenicity and explores their dual role as immunomodulatory adjuvants. Innovative delivery methods, such as microneedles, patches, and inhalable systems, are discussed as minimally invasive alternatives to traditional administration routes. …”
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