Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side Effects by Renxin Zhang, Zhiyuan Chen, Shuhan Li, Haohao Lv, Jinjun Li, Naixue Yang, Shaoxing Dai

“…These findings demonstrate the utility of pocket similarity in drug repositioning, target expansion, and improved drug safety evaluation, offering new avenues for the discovery of new indications and side effects of existing drugs.…”
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Systematic review of spontaneous reports of myocarditis and pericarditis in transplant recipients and immunocompromised patients following COVID-19 mRNA vaccination by Saad Shakir, Samantha Lane, Alison Yeomans

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Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride by Amr M. Mahmoud, Nariman A. El-Ragehy, Maha A. Hegazy, Samia A. Tawfik, Ghada A. Sedik

“…Moreover, the suggested sensor has a significant potential to monitor patients’ plasma level to guarantee drug safety and effectiveness. Additionally, three different approaches namely; Analytical EcoScale, Analytical GREEnness metric approach and finally, the most recent one; Red-Green-Blue model were applied to evaluate the greenness and whiteness profile of the developed method.…”
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Drug-induced urinary retention: a real-world pharmacovigilance study using FDA and Canada vigilance databases by Xianyu Dai, Kai Yu, Yu Chang, Yuchuan Hou

“…The validation of new signals for Abiraterone, Fluoxetine, and Empagliflozin underscores the critical need for continuous drug safety monitoring and targeted research to better understand the mechanisms behind drug-induced UR.…”
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TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator by Sayeri Lala, Niraj K. Jha

“…Abstract Background Phase-3 clinical trials provide the highest level of evidence on drug safety and effectiveness needed for market approval by implementing large randomized controlled trials (RCTs). …”
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Protocol of DEXPED trial: efficacy of intravenous dexamethasone, administered at the time of analgesic blocking of the lower limb, on postoperative pain in children: a randomised,... by Nathalie Thilly, Nicolas Vautrin, Yohann Bernard, François Wurtz, Claude Meistelman

“…The secondary objectives are the evaluation of the effect of a single-dose intravenous dexamethasone at the time of anaesthetic induction, on the following parameters: onset of postoperative pain, duration of motor block, postoperative nausea and vomiting within 24 hours.Ethics and dissemination This study is conducted according to the principles of the Declaration of Helsinki and has been approved by the French national ethics committee and the National Drug Safety Agency. Findings of this study will be widely disseminated through conference presentations, reports, factsheets and academic publications.Trial registration number NCT03618173.…”
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Assessment of potential drug-drug interactions in hospitalized patients with infectious diseases: an experience from a secondary care hospital [version 4; peer review: 2 approved,... by Padma G.M. Rao, Rashid Ain Ur, Sathvik Belagodu Sridhar, Abu Nawa Ahmad Ismail, Javedh Shareef

“…Prescription screening using a drug information database assists in identifying and preventing DDIs early, enhancing drug safety and quality of patient-centered care.…”
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Simultaneous Determination of Night Effective Constituents and Correlation Analysis of Multiconstituents and Antiplatelet Aggregation Bioactivity In Vitro in Chuanxiong Rhizoma Sub... by Peihua Zhang, Linming Chen, Xiaoxiao Wang, Jinpei Chen, Shungui Xu, Ling Ye, Yixin Yao

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Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and Rabbits by Jun Zhou, Christopher J. Bowman, Vicki R. Markiewicz, Balasubramanian Manickam, Emily Gomme, Rani S. Sellers, Cynthia M. Rohde

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Evaluation of Knowledge and Practice of Pharmacy Professionals regarding the Risk of Medication Use during Pregnancy in Dessie Town, Northeast Ethiopia: A Cross-Sectional Study by Abdu Tuha, Yilak Gurbie, Haftom Gebregergs Hailu

“…Overall, PPs exhibited very low knowledge about drug safety during pregnancy. The absence of obligatory continuing pharmacy education for pharmacists is expected to have negatively affected the level of medication knowledge and consequently the pharmaceutical care services delivered in community and hospital pharmacies. …”
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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

“…The higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality attribute with strong contribution to clinically relevant biological functions and drug safety. Due to the multi-faceted nature of HOS, the synergy of multiple complementary analytical approaches can substantially improve the understanding, accuracy, and resolution of HOS characterization. …”
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The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate by Laetitia Clotaire, Isabelle Rubera, Christophe Duranton, Jocelyn Gal, Emmanuel Chamorey, Hélène Humeau, Samir Yamani, Christine Chiaverini, Serge Willoteaux, Bernard Padovani, Laurie Mourozeau, Adam Mainguy, Stéphanie Baillif, Ludovic Martin, Georges Leftheriotis

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Cannabis related side effects in otolaryngology: a scoping review by Jobanjit S. Phulka, Joel W. Howlett, Amanda Hu

“…Health Canada defines side effect as a harmful and unintended response to a health product. Given drug safety concerns, this study’s purpose was to review the unintended side effects of cannabis in otolaryngology. …”
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Therapeutic Drug Monitoring of Vancomycin in Hemodialysis Patients in a Hospital in North-East Romania by Aurelia Crețu, Luanda Irina Mititiuc, Iulia-Daniela Lungu, Mihaela Mihaila, Irina Dima, Adrian Covic, Cristina Mihaela Ghiciuc

“…We conducted a prospective study, evaluating the needs of changes in vancomycin dosing for treatment based on the use of the new 2020 vancomycin dosing guidelines, to increase drug safety (preventing subtherapeutic or supratherapeutic doses and offering therapeutic concentrations of the drug) in a particular group of patients with sepsis caused by catheter infections and being on intermittent hemodialysis. …”
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Dendrobium chrysotoxum Lindl. Alleviates Diabetic Retinopathy by Preventing Retinal Inflammation and Tight Junction Protein Decrease by Zengyang Yu, Chenyuan Gong, Bin Lu, Li Yang, Yuchen Sheng, Lili Ji, Zhengtao Wang

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Determination of the Contents of Antioxidants and Their Degradation Products in Sodium Chloride Injection for Blood Transfusion by Bo Tao, Gang Wang, Zongning Yin, Xiaocong Pu, Yan Jiang, Luohong Zhang, Jie Cheng, Yong Li, Jiayu Zhang

“…Therefore, the antioxidants and their degradation products migrating into the drug solution would not cause drug safety risks.…”
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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

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Impact of Food Physical Properties on Oral Drug Absorption: A Comprehensive Review by Wang Z, Xu W, Liu D, Li X, Liu S, Wu X, Wang H

“…Although scientists have deeply studied the role of food components–such as proteins, fats, and carbohydrates–in drug absorption, the impact of food’s physical properties, like viscosity, volume, and temperature, on drug safety is often overlooked. Dietary differences across cultures, such as the sticky porridge and steamed buns in China versus bread and milk in the West, suggest that food properties may differentially affect drug absorption. …”
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Experiencing the risk of overutilising opioids among patients with chronic non-cancer pain in ambulatory care (ERONA): the protocol of an exploratory, randomised controlled trial by Odette Wegwarth, Joerg J Meerpohl, Norbert Donner-Banzhoff, Claudia Spies, Christine Schmucker, Erika Schulte, Edris Nury, Dirk Brockmann, Stefan Wind, Eva Goebel, Wolf-Dieter Ludwig, Ralph Hertwig

“…Findings from cognitive and decision science in areas other than drug safety suggest that people’s risk perception and behaviour can differ depending on whether they learnt about a risk through personal experience or description. …”
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Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

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