Integrating socio-economic support into drug-resistant TB care to optimise treatment outcomes by J. Limo, C. Pahe, I. Kathure, L. Ndungu, A. Mahihu, C. Mwashumbe, E. Mueni, H. Momanyi

“…BACKGROUND: Drug-resistant TB (DR-TB) remains a public health concern in Kenya, with an estimated 2,500 individuals acquiring DR-TB annually. …”
Get full text

Existence of multiple-stable equilibria for a multi-drug-resistant model of mycobacterium tuberculosis by Abba B. Gumel, Baojun Song

Subjects: “…key words and phrases. multi-drug-resistant tb…”
Get full text

Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta. by Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Duncan Berger, Daniel R G Price, Sam Dougan, Dionysis Grigoriadis, Alan Tracey, Nancy Holroyd, Katie Bull, Hannah Rose Vineer, Mike J Glover, Eric R Morgan, Alasdair J Nisbet, Tom N McNeilly, Yvonne Bartley, Neil Sargison, Dave Bartley, Matt Berriman, James A Cotton, Eileen Devaney, Roz Laing, Stephen R Doyle

“…To understand the genetics of drug resistance, we have generated a highly contiguous genome assembly for the UK T. circumcincta isolate, MTci2. …”
Get full text

Geospatial mapping of drug-resistant tuberculosis prevalence in Africa at national and sub-national levels by Alemneh Mekuriaw Liyew, Archie C.A. Clements, Fasil Wagnew, Beth Gilmour, Kefyalew Addis Alene

Subjects: “…Drug-resistant tuberculosis…”
Get full text

Treatment completion of drug-resistant tuberculosis in Ethiopia: A perspective from healthcare users. by Ahmed Reshid Tusho, Sheila Theresa Mokoboto-Zwane

“…Drug-resistant tuberculosis remains a persistent public health threat. …”
Get full text

Surgical Cryoablation of Drug Resistant Ventricular Tachycardia and Aneurysmectomy of Postinfarction Left Ventricular Aneurysm by Marek Pojar, Jan Harrer, Nedal Omran, Martin Vobornik

Get full text

The role of complement in tumor immune tolerance and drug resistance: a double-edged sword by Ronghui Yang, Di Fu, Di Fu, Aijun Liao

Subjects: Get full text

Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance by Peng Zhao, Shuangshuang Yin, Yuling Qiu, Changgang Sun, Haiyang Yu

“…Abstract Drug resistance is a common challenge in clinical tumor treatment. …”
Get full text

Modeling and simulation of distribution and drug resistance of major pathogens in patients with respiratory system infections by Li Yang, Ermin Liang, Yali Gao

“…A mathematical model was developed to simulate the relationship between pathogen distribution and drug resistance. Results The most common pathogens were Streptococcus pneumoniae (30%), Haemophilus influenzae (20%), Pseudomonas aeruginosa (15%), Staphylococcus aureus (10%) and Klebsiella pneumoniae (10%). …”
Get full text

Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria by Amrutha Surendran, Agnes Turnbull, Allen Flockhart, Fern Findlay-Greene, Martyna Nowosielska, Donald Morrison, David J. Mincher, Samantha Donnellan

“…Key policy highlights Development of a novel class of antimicrobial compounds Drug screen against a WHO ‘high’ priority drug-resistant pathogen that poses the greatest threat to human health (methicillin-resistant Staphylococcus aureus) Drug screen against a surrogate for Mycobacterium tuberculosis, one of the leading causes of mortality worldwide.…”
Get full text

Antimicrobial susceptibility patterns of pathogens isolated from clinical specimens at a tertiary care hospital in Bangladesh, 2020–2023 by Mohammad Kamruzzaman, Fahim Alam Nobel, Saiful Islam, Amiyo Haider, Mohammad Nasir Uddin, Mohammod Johirul Islam

Subjects: “…Multi-drug resistance…”
Get full text

Integrating Laboratory and Epidemiological Techniques for Population-Based Surveillance of HIV Strains and Drug Resistance in Canada by Gayatri C Jayaraman, Chris P Archibald, Lee Li Lior, Donald Sutherland

Get full text

Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…Variants in genes encoding for voltage-gated K+ (Kv) channels are frequent cause of drug-resistant pediatric epilepsies. Obtaining a molecular diagnosis gives the opportunity to assess the efficacy of pharmacological strategies based on in vitro features of mutant channels. …”
Get full text

Progress in programmatic management of drug-resistant TB, WHO Eastern Mediterranean Region, 2018-2023 by K. Bennani, M. van den Boom, M.G. ElMedrek, Y. Hutin

“…BACKGROUND: Since 2012, WHO has supported countries in scaling up programmatic management of drug-resistant tuberculosis (PMDT). We assessed progress and challenges to formulate recommendations for improvement. …”
Get full text

Treating drug-resistant tuberculosis in an era of shorter regimens: Insights from rural South Africa by J-D K Lotz, J Porter, H Conradie, T Boyles, B Gaunt, S Dimanda, D Cort

Subjects: Get full text

To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics by Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

Get full text

Cost and cost-effectiveness of BPaL regimen used in drug-resistant TB treatment in the Philippines by D. Evans, K. Hirasen, D.J. Casalme, M.T. Gler, A. Gupta, S. Juneja

“…BACKGROUND: In 2022, the WHO announced that the 6-month BPaL/M regimen should be used for drug-resistant TB (DR-TB). We estimate the patient and provider costs of BPaL compared to current standard-of-care treatment in the Philippines.METHODS: Patients on BPaL under operational research, or 9–11-month standard short oral regimen (SSOR) and 18–21-month standard long oral regimen (SLOR) under programmatic conditions were interviewed using the WHO cross-sectional TB patient cost tool. …”
Get full text

Primary HIV Drug Resistance among Recently Infected Cases of HIV in North-West India by C. K. Chauhan, P. V. M. Lakshmi, V. Sagar, A. Sharma, S. K. Arora, R. Kumar

“…Antiretroviral treatment may lead to the emergence of HIV drug resistance, which can be transmitted. HIV primary drug resistance (PDR) is of great public health concern because it has the potential to compromise the efficacy of antiretroviral therapy (ART) at the population level. …”
Get full text

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance by Xiaoyan Zhang, Huaijun Tu, Yazhi Yang, Lijun Fang, Qiong Wu, Jian Li

Get full text

Nitrofurantoin Drug Resistance Among Gram-Negative Bacteria Isolated from Urinary Tract Infections by Puranik VS, Balaraju T P, Pavitra T

“…Nitrofurantoin resistance was the highest in Acinetobacter sp.Conclusion Nitrofurantoin drug is commonly prescribed in uncomplicated UTIs and is frequently used in the treatment of multi drug resistant infections. It is very important to identify urinary tract pathogens up to species level. …”
Get full text