Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits <i>MNRR1</i>, a Druggable Target in MELAS by Neeraja Purandare, Vignesh Pasupathi, Yue Xi, Vikram Rajan, Caleb Vegh, Steven Firestine, Tamas Kozicz, Andrew M. Fribley, Lawrence I. Grossman, Siddhesh Aras

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Clopidogrel for Proteinuria Reduction in Focal Segmental Glomerulosclerosis: Phase 2 Trial Design by Lisa Daniel-Fischer, Marlies Antlanger, Daniel Cejka, Kathrin Eller, Philipp Gauckler, Balazs Odler, Michael Rudnicki, Marcus D. Säemann, Alice Schmidt, Gere Sunder-Plassmann, Martin Wiesholzer, Martin Windpessl, Emanuel Zitt, Franz Koenig, Larry A. Greenbaum, Andreas Kronbichler, Christoph Aufricht

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Pilocarpine inhibits Candida albicans SC5314 biofilm maturation by altering lipid, sphingolipid, and protein content by Emerenziana Ottaviano, Michele Dei Cas, Silvia Ancona, Francesca Triva, Sara Casati, Francesca Sisto, Elisa Borghi

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Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation by Chawalit Ngernsombat, Utid Suriya, Pongphol Prattapong, Kanika Verma, Thanyada Rungrotmongkol, Thananya Soonkum, Sakonwan Kuhaudomlarp, Tavan Janvilisri

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Risk of End-Stage Kidney Disease and Topiramate Use by Jean-Michel Halimi, Valentin Maisons, Jean-Baptiste de Fréminville, Sébastien Roger, Arnaud Bisson, Stéphanie Chadet, Laurent Fauchier

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Drug Repurposing for Rare Orphan Diseases Using Machine Learning Techniques by Rajesh Manicavasaga, Prabin B Lamichhane, Prajjwal Kandel, Douglas A. Talbert

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In vivo evidence of metformin and aspirin antibacterial activity against Staphylococcus aureus in Drosophila infection model by Firzan Nainu, Muh. Akbar Bahar, Habibie Habibie, Yenni Yusuf, Sartini Sartini, Mukarram Mudjahid, Nadila Pratiwi Latada, Gimas Fatir Bijaksana, Aditya Satya Pratama, Jihan Atikah Permatasari, Asbah Asbah

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Genome-wide association study −Driven drug repositioning for the treatment of insomnia by Rahmat Dani Satria, Wirawan Adikusuma, Usi Sukorini, Devy Eka Avitasari, Indra Sari Kusuma Harahap, Mohammad Hendra Setia Lesmana, Lalu Muhammad Irham, Nur Imma Fatimah Harahap, Pranindya Rinastiti, Donytra Arby Wardhana, Richardus Wisnandito Prabasaktya, Chiou-Feng Lin, Aprilia Paramitasari, Andrian Fajar Kusumadewi

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A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics by Richard Head, Saiful Islam, Jennifer H. Martin

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REPURPOSING DRUGS FOR CANCER THERAPY by Ege Arzuk, Ali Ergüç, Fuat Karakuş

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Artificial Intelligence-Based Methods for Drug Repurposing and Development in Cancer by Sara Herráiz-Gil, Elisa Nygren-Jiménez, Diana N. Acosta-Alonso, Carlos León, Sara Guerrero-Aspizua

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Radiation-induced morphea of the breast – characterization and treatment of fibroblast dysfunction with repurposed mesalazine by Stephan R. Künzel, Erik Klapproth, Nick Zimmermann, Susanne Kämmerer, Mario Schubert, Karolina Künzel, Maximilian Hoffmann, Stephan Drukewitz, Anne Vehlow, Jiri Eitler, Marieke Arriens, Jessica Thiel, Romy Kronstein-Wiedemann, Maximiliane Tietze, Stefan Beissert, Bertold Renner, Ali El-Armouche, Claudia Günther

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Experimental Justification of Reprofiling of the Drug Maxar® for the Treatment of Viral Infections by T. S. Zaporozhets, N. V. Krylova, S. A. Fedoreyev, O. V. Iunikhina, A. B. Pott, D. V. Tarbeeva, N. P. Mishchenko, M. Yu. Shchelkanov

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Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy by Smita Dey, Prerika Mathur, Sudeshna Mukherjee, Rajdeep Chowdhury, Syamantak Majumder, Aniruddha Roy, Shibasish Chowdhury

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Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions by Gianmarco Gualtieri, Emanuele Liborio Citriniti, Roberta Rocca, Valentina Arciuolo, Jussara Amato, Antonio Randazzo, Stefano Alcaro

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Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms by She Pengfei, Yang Yifan, Liu Shasha, Guo Shaowei, Huan Guanqing, Xiao Dan, Wu Yong

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Treatment of overactive KATP channels with glibenclamide in a zebrafish model and a clinical trial in humans with Cantú syndrome by Lotte Kleinendorst, Sarah E. Siegelaar, Helen I. Roessler, Lema Meiwand, Malou van den Boogaard, Rianne H.A.C.M. de Bruin-Bon, Kirsten F. van Duinen, R. Nils Planken, Elisabeth H. Jaspars, Patrick M.J.H. Kemperman, Berto J. Bouma, Colin G. Nichols, Marcel W. Bekkenk, Gijs W. van Haaften, Mieke M. van Haelst

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IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

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Repurposed Drugs to Enhance the Therapeutic Potential of Oligodendrocyte Precursor Cells Derived from Adult Rat Adipose Tissue by J. Pascual-Guerra, M. Torres-Rico, B. Marín-Rodríguez, M. S. Arasmou-Idrovo, A. G. García, J. A. Rodríguez-Navarro, C. L. Paíno

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Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics by Jordan C. Langston, Dan Liu, Qingliang Yang, Salim Merali, Carmen Merali, Narender Singh, Jennifer L. Fisher, Balabhaskar Prabhakarpandian, Laurie E. Kilpatrick, Mohammad F. Kiani, Mohammad F. Kiani

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