Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway by Wang Fengling, Ye Xi, Zhai Dandan, Dai Wenting, Wu Yifan, Chen Jin, Chen Weidong

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Ataxia and Seizures despite Phenytoin: A Case Report Highlighting the Importance of TDM and Genetic Influences by Rachel Manoj, Arpita Meher, Jefry Winner G.

“…This case underscores the significance of TDM, genetic considerations in drug metabolism, and the need to be vigilant in treating epilepsy to prevent such adverse events.…”
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Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics by Guangqing Xiao, Liang-Shang Gan

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The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity by Cong Han, Ran-ran Gao, Le Zhou, Wei Li

“…The six pathways related to energy metabolism driven by L. reuteri, including the citrate cycle, ascorbate and alderate metabolism, proximal tube bicarbonate metabolism, glycolysis/gluconeogenesis, ferroptosis, drug metabolism–cytochrome P450, are important mechanisms.…”
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A case-control genome-wide association study of estimated breeding values for resistance to gastrointestinal nematodes in two local dairy sheep breeds by C. Persichilli, S. Biffani, G. Senczuk, M. Di Civita, M.K. Bitew, A. Bosco, L. Rinaldi, S. Grande, G. Cringoli, F. Pilla

“…Many of these pathways were involved in the regulation of the immune response, drug metabolism and detoxification, and vitamin metabolism. …”
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The controversies of parabens – an overview nowadays by Petric Zvonimir, Ružić Julia, Žuntar Irena

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HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm. by Mengyao Zhou, Mengfan Xu, Xiangling Zhang, Xiaochun Xing, Yang Li, Guanghui Wang, Guiying Yan

“…We first reconstruct a novel angina pectoris drug dataset, which include drug name, drug metabolism, chemical formula, targets and pathways, then construct a comprehensive human pathway network based on the genetic similarity of the pathways which contain information about the targets. …”
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Improving breast cancer treatments using pharmacomicrobiomics by Aswin Anand Pai, Aadra Prashant Bhatt

“…However, a significant proportion of patients experience disease recurrence due to treatment failure attributed to various factors, including disease pathology, genetics, and drug metabolism. Alam et al. introduce gut microbiota as a key factor influencing tamoxifen pharmacokinetics (Y. …”
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Relapsing Malaria: A Case Report of Primaquine Resistance by Christopher Dijanic, Jillian Nickerson, Sunita Shakya, Amanda Dijanic, Marilyn Fabbri

“…However, in patients with repeated treatment failure, we must consider CYP-450 mutations affecting drug metabolism as an important cause of relapse. A 47-year-old man who travelled to a jungle in Venezuela was diagnosed with P. falciparum and P. vivax in July 2015. …”
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Pramipexole Extended Release: A Novel Treatment Option in Parkinson's Disease by Wolfram Eisenreich, Bernd Sommer, Sebastian Hartter, Wolfgang H. Jost

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Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species by Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodríguez

“…Furthermore, transcriptomic evidence is revealing that biological sex is a variable impacting physiology, immune response, drug metabolism, and consequently, the progression of disease. …”
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A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels by Subrata Deb, Prasanth Puthanveetil, Prashant Sakharkar

“…Underlying hepatic pathophysiology from dyslipidemia deserves further exploration due to its potential effects on hepatic drug metabolism/detoxification.…”
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Drugs of Abuse Can Entrain Circadian Rhythms by Ann E. K. Kosobud, Andrea G. Gillman, Joseph K. Leffel, Norman C. Pecoraro, G. V. Rebec, William Timberlake

“…This could be the basis for known daily variations in drug metabolism, tolerance, and sensitivity to drug reward. …”
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The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me... by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

“…The transcriptome data revealed the involvement of many differentially expressed genes in chemical carcinogenesis, drug metabolism, and metabolism of xenobiotics by cytochrome P450. …”
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Untargeted urine metabolomics reveals dynamic metabolic differences and key biomarkers across different stages of Alzheimer’s disease by Xiaoya Feng, Shenglan Zhao

“…Pathway enrichment analysis revealed that Drug metabolism was significantly enriched across all stages, while Retinol metabolism was particularly prominent during the transition stages. …”
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Tumor microbiome: roles in tumor initiation, progression, and therapy by Shengxin Zhang, Jing Huang, Zedong Jiang, Huan Tong, Xuelei Ma, Yang Liu

“…Additionally, tumor microbiome is closely associated with drug resistance and influences therapeutic efficacy by modulating immune responses, drug metabolism, and apoptotic pathways. Furthermore, we explore innovative microbe-based therapeutic strategies, such as engineered bacteria, oncolytic virotherapy, and other modalities aimed at enhancing immunotherapeutic efficacy, paving the way for microbiome-centered cancer treatment frameworks.…”
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Interaction of α-Cembrenediol with Human Serum Albumin Based on Spectroscopic and Computational Analyses by Xian-Kun Su, Zhen-Chun Sun, Chang-You Zhao, Hui Yang, Tian-Ming Zhao, Chao Ma, Guo-Fei Zhu

“…However, knowledge of the absorption, transport, and release of α-cembrenediol in drug metabolism within the body is currently limited. …”
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The AhR pathway regulation in phthalates-induced cancer promotion, progression and metastasis: a scoping review by Mostafa Akbariani, Mahmoud Omidi, Zohreh Shahabi, Hamed Haghi-Aminjan, Amir Shadboorestan

“…Specifically, DEHP activated AhR, leading to elevated expression of EMT markers, increased cancer stem cell populations, and enhanced drug metabolism and resistance. Other phthalates, such as Butyl Benzyl Phthalate (BBP), also activated AhR-mediated pathways, promoting angiogenesis and metastasis. …”
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Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease by Tomonori Sugita, Katsushi Amano, Masanori Nakano, Noriko Masubuchi, Masahiro Sugihara, Tomokazu Matsuura

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Comparison of target concentration of propofol during three phases of live donor liver transplant surgery using a target-controlled infusion of propofol total intravenous anaesthes... by Neha Garg, Yatin Kalra, Shivali Panwar, Mahesh K. Arora, Udit Dhingra

“…Background and Aims: Three phases (dissection, anhepatic, and neohepatic) exist for propofol pharmacokinetics during liver transplantation (LT), resulting in varying cardiac output, volume of distribution, and drug metabolism. The primary objective was to compare the mean target concentration of propofol required to maintain the bispectral index (BIS) between 40 and 60 during three phases of LT by using a target-controlled infusion of total intravenous anaesthesia (TCI-TIVA). …”
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