Survey on Tunisian Dentists’ Anti-Inflammatory Drugs’ Prescription in Dental Practice by Line Berhouma, Amira Besbes, Abdellatif Chokri, Jamil Selmi

“…According to this study, dentists have a lack of knowledge and awareness about some contraindications, side effects, and drugs interactions. Thus, knowledge updating, practices assessment, and continuous education are always required to avoid drug iatrogenesis.…”
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Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS by Weiyi Cao, Hezhi Yao, Zhenzhen Qian, Yi Wu, Shuge Wang, Rui Li, Rui Gao

“…To support clinical studies on drug-drug interactions (DDIs) between salvianolate injection and aspirin, a rapid and sensitive UPLC-MS/MS method for the simultaneous determination of aspirin (acetylsalicylic acid), its metabolite salicylic acid, and salvianolic acid B in human plasma was developed. …”
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Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures by Mariana Nunes, Sara Ricardo

“…For all the combinations tested, at least one model indicated an additive effect; however, only the combination of Paclitaxel and Ivermectin consistently demonstrated an additive effect across all chemoresistant cell lines cultured in 3D models, as well as in all four synergy reference models used to assess drug interactions. Conclusions: Combining Paclitaxel with Ivermectin has the highest cytotoxic and the strongest additive effect for both chemoresistant cell lines compared to Paclitaxel alone.…”
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Anticoagulant Utilization and Cost Analysis among Cardiology Inpatients in a Tertiary Care Teaching Hospital of Western Nepal by Sabina Sankhi, Nirmal Raj Marasine, Parbati Thapa, Nim Bahadur Dangi

“…Heparin was associated with the majority of cases of drug interactions (52 cases). Enoxaparin was the most expensive of all the anticoagulant drug classes. …”
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A Case of Undiagnosed HIV Infection in a 57-Year-Old Woman with Multiple Myeloma: Consequences on Chemotherapy Efficiency and Safety by I. Poizot-Martin, S. Brégigeon, C. Tamalet, R. Bouabdallah, O. Zaegel-Faucher, V. Obry-Roguet, A. Ivanova, C.E. Cano, C. Solas

“…A multidisciplinary approach including oncologists/hematologists, virologists, and pharmacists is recommended in order to avoid drug interactions between chemotherapy and antiretroviral drugs. …”
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Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights by Mislav Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Andrea Gelemanović, Andrea Faour, Ivan Vlak, Josipa Radić

“…The use of tetracycline for RA is restricted by drug interactions causing bacterial resistance alongside unpredictable patient responses, hence the necessity for prudence in its prescription within a clinical setting. …”
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Study of Treatment in Heart Disease Patients Installation in Undata Hospital, Central Sulawesi by Niluh Puspita Dewi, Indah Kurnia Utami, Al'vira Gunawan, Muh. Thamrin Tahir, Syafika Alaydrus, Nani Astria Polontalo

“…Recommendedsfor further researchersscan conduct research on cardiac drug interactions.…”
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Medicinal plants as alternatives for the management of hypertension and diabetes in Nigeria: Analysis of the structured interview of Nigerian patients by Rosemary A. Sylver-Francis, Olavi Pelkonen

“…Potentially, the use may predispose patients to severe hypotension or hypoglycaemia and other adverse effects e.g. drug interactions and direct toxicities. Also, poor quality and scanty or anecdotal directions of TMPs raises safety concerns. …”
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Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review by Nidhi Garg, Ananya Sree Kunamneni, Pankaj Garg, Sandeep Sharma, Divakar Sharma, Adinarayana Kunamneni

“…If Paxlovid is not available or cannot be administered due to drug interactions, then the next best choice is sotrovimab. …”
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Continuous Consumption of Reused Palm Oil Induced Hepatic Injury, Depletion of Glutathione Stores, and Modulation of Cytochrome P450 Profiles in Mice by Waranya Chatuphonprasert, Yollada Sriset, Kanokwan Jarukamjorn

“…It is therefore recommended that fresh rather than reused palm oil be used for cooking, and large-scale or long-term consumption be avoided to reduce the risk of liver damage and drug-interactions.…”
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Drug Use Evaluation of Beta-Blockers in Medical Wards of Nedjo General Hospital, Western Ethiopia by Ginenus Fekadu, Firomsa Bekele, Kumera Bekele, Sagni Hanbisa, Gemechis Belay, Mudasir Maqbool

“…Regarding the routes of administration, 70 (46.98%) of them were prescribed with the correct route. Most drugs interacting were propranolol with cimetidine 26 (68.42%), and the most frequent condition for which beta-blockers were prescribed was hypertension (32.89%). …”
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Pharmacometabolomics Enables Real-World Drug Metabolism Sciences by Fleur B. Nijdam, Marieke A. J. Hof, Hans Blokzijl, Stephan J. L. Bakker, Eelko Hak, Gérard Hopfgartner, Frank Klont, on behalf of the TransplantLines Investigators

“…However, these genotypes rely heavily on the availability and completeness of drug metabolism information and do not account for (all) “phenoconversion” factors, like drug–drug interactions and comorbidities. To address these limitations, a more phenotypic approach would be desirable, for which pharmacometabolomics (PMx) could be useful by studying and elucidating drug metabolism in patient samples, such as blood and urine. …”
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Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial -... by Keiichi Fukuda, Satoshi Yasuda, Hiroyuki Tsutsui, Toyoaki Murohara, Kohtaro Abe, Koichiro Tatsumi, Junji Kishimoto, Yu Taniguchi, Yuichi Tamura, Koji Todaka, Shun Minatsuki, Kazuya Hosokawa, Yuko Kobayakawa, Takumi Inami, Nobutaka Ikeda

“…The anticoagulant activity of warfarin is affected by food and drug interactions, requiring regular monitoring of prothrombin time. …”
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Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning by Sajid Naveed, Mujtaba Husnain, Ali Samad, Amna Ikram, Hina Afreen, Ghulam Gilanie, Najah Alsubaie

“…The Genomics of Drug Sensitivity in Cancer (GDSC) database was used as the primary data source, containing 135,242 cell line-drug interactions, inhibitory concentration of cancer drug for more than 800 cancer cell lines. …”
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The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis by Mubara Azhar, Mohammed S. Alasmari, Ammara Zamir, Hamid Saeed, Faleh Alqahtani, Tanveer Ahmad, Muhammad Fawad Rasool

“…This systematic review aims to provide detailed knowledge about the pharmacokinetics (PK), the associated pharmacodynamics (PD), and the drug interactions of GLM, which can be used to assess key parameters and identify factors influencing variability across diverse populations and clinical settings. …”
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Challenges and barriers to physician decision-making for prescribing and deprescribing among patients with multimorbidity in eastern China’s primary care settings: a qualitative st... by Ming Yan, Zhijie Xu, Andrew Farmer, Yu Xia, Mi Yao, Lingyan Wu, Xinmei Zhou, Liyan Han

“…These challenges stemmed from three key areas: (1) difficulties in identifying drug-disease and drug-drug interactions; (2) cognitive biases in medication benefit-risk evaluation and (3) heavy treatment burden. …”
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Helicobacter pylori infection at long-term treatment by proton pump inhibitors for acid-related diseases (Literature review and resolution of Advisory council, March 22, 2018) by V. T. Ivashkin, I. V. Mayev, R. A. Abdulkhakov, O. P. Alekseyeva, S. A. Alekseyenko, A. Yu. Baranovsky, Ye. K. Baranskaya, I. L. Klyaritskaya, N. V. Korochanskaya, Yu. A. Kucheryavy, T. L. Lapina, M. F. Osipenko, V. I. Simanenkov, G. N. Tarasova, A. S. Trukhmanov, I. B. Khlynov, A. A. Sheptulin

“…The choice of specific PPI for treatment of patients with GERD and other acid-related diseases, carrying out H. pylori eradication therapy or substitution of one PPI agent to another are individualized and depend on the indications registered in the drugs administration instructions, features of its pharmacokinetics and pharmacodynamics, possible drug-to-drug interactions. Conclusion. Testing for H. pylori infection and carrying out the subsequent eradication therapy could allow to prevent progression of corpus mucosa atrophy in patients with acid-related disorders, first of all those with GERD, who received long-term PPI treatment. …”
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Experiences and Perspectives of Medication Information and Use Among Arabic-Speaking Migrant Women in Sweden: A Multistage Focus Group Study by Al Musawi A, Axelsson M, Eriksson T, Rämgård M

“…Suggestions for improvement included providing written medication information at discharge in their native language, using interpreters, and including a current medication list detailing overall medication information and potential drug interactions.Conclusion: This study highlights inadequate medication information provision to Arabic-speaking migrant women, which may impact medication use and pose patient safety risks. …”
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Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study by Johanna P. van Gemert, Bart Luijk, Merel E. Hellemons, Klara A. Visser, Carina.M.E. Hansen, Renske van der Meer, C. Tji Gan, Hester van der Vaart, Onno W. Akkerman, Willie N. Steenhuis, Marieke Verkleij, Harry G.M. Heijerman, Erik A.M. Verschuuren

“…Background: Elexacaftor/Tezacaftor/Ivacaftor (ETI) for people with CF (PwCF) after lung transplantation (LTx) has been restrained due to uncertainties regarding efficacy and drug interactions. Given the persistence of extrapulmonary symptoms post-LTx, this prospective study aims to investigate the benefits and safety of ETI for PwCF post-LTx. …”
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Efficacy of combined colorectal cancer treatment in senile patients by P. V. Tsarkov, D. R. Markaryan, V. M. Nekoval

“…Due to complex drugto-drug interactions specificity of metabolism and biological tumor properties, cross-reactions of concomitant diseases in senile patients each step of combined treatment should be discussed at multidisciplinary consultation.…”
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