Drug discovery: a multifactorial ecosystem by Fernando Albericio

Get full text

RNA Editing and Drug Discovery for Cancer Therapy by Wei-Hsuan Huang, Chao-Neng Tseng, Jen-Yang Tang, Cheng-Hong Yang, Shih-Shin Liang, Hsueh-Wei Chang

“…Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. …”
Get full text

A guide for active learning in synergistic drug discovery by Shuhui Wang, Alexandre Allauzen, Philippe Nghe, Vaitea Opuu

“…Abstract Synergistic drug combination screening is a promising strategy in drug discovery, but it involves navigating a costly and complex search space. …”
Get full text

New strategies to enhance the efficiency and precision of drug discovery by Qi An, Liang Huang, Chuan Wang, Dongmei Wang, Yalan Tu

Subjects: “…drug discovery…”
Get full text

Super-resolution microscopy as a drug discovery tool by Lauren Toms, Lorna FitzPatrick, Philip Auckland

“…Now, after nearly two decades, super-resolution microscopy has begun to address previously unmet challenges in the study of human disease and is poised to become a pivotal tool in drug discovery.…”
Get full text

Linking machine learning and biophysical structural features in drug discovery by Armin Ahmadi, Shivangi Gupta, Vineetha Menon, Jerome Baudry

Subjects: “…drug discovery…”
Get full text

Drug discovery and mechanism prediction with explainable graph neural networks by Conghao Wang, Gaurav Asok Kumar, Jagath C. Rajapakse

Get full text

Unleashing the Power of Artificial Intelligence-Driven Drug Discovery in Streptomyces by Wei-Shan Ang, Jodi Woan-Fei Law, Yatinesh Kumari, Vengadesh Letchumanan, Loh Teng-Hern Tan

“…Graphical abstract: The role of machine learning in drug discovery from Streptomyces. …”
Get full text

Unveiling the therapeutic potential of insect-derived natural products for drug discovery by Jasha Momo H. Anal, Lobeno Mozhui, Samuel Lalthazuala Rokhum

Subjects: Get full text

Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery by Leonel Pereira, Ana Valado

Subjects: Get full text

Malaysia’s Breakthrough in Modern Actinobacteria (MOD-ACTINO) Drug Discovery Research by Angel Yun-Kuan Thye, Vengadesh Letchumanan, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Learn-Han Lee

Get full text

Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

Subjects: Get full text

Novel 4-aminoquinazoline derivatives as new leads for anticancer drug discovery by Ghorab Mostafa M., Alsaid Mansour S.

Get full text

Applied of bioinformatics in drug discovery and drug development: Bioinformatic analysis 1996-2024 by Irham Lalu Muhammad, Amukti Danang Prasetyaning, Adikusuma Wirawan, Singh Dilpreet, Chong Rockie, Basyuni Mohammad, Pranata Satriya, Hilmi Isom, Khairi Sabiah

“…Drug discovery and drug development were two complex process to find new drugs. …”
Get full text

Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Methods. A computational drug discovery approach was performed using the AutoDock tool to identify potential MAPK3 inhibitors from 46 plant-based flavonoids. …”
Get full text

Bridging the gap: From petri dish to patient - Advancements in translational drug discovery by Mohamed El-Tanani, Syed Arman Rabbani, Yahia El-Tanani, Ismail I. Matalka, Ikramy A. Khalil

Subjects: Get full text

3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment by Aida Rodriguez-Garcia, Jacqueline Oliva-Ramirez, Claudia Bautista-Flores, Samira Hosseini

“…Organ-on-chip devices, including in vitro modelling of 3D organoids, 3D microfabrication, and 3D bioprinted platforms, play an essential role in drug discovery, testing, and assessment. In this article, a thorough review is provided of the latest advancements in the area of organ-on-chip devices targeting liver, kidney, lung, gut, heart, skin, and brain mimicry devices for drug discovery, development, and/or assessment. …”
Get full text

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Abstract Background Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. …”
Get full text

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery. by Mohammed Alrouji, Sabina Yasmin, Mohammed S Alshammari, Fahad A Alhumaydhi, Sharaf E Sharaf, Moyad Shahwan, Anas Shamsi

Get full text

Exploring Fragment Adding Strategies to Enhance Molecule Pretraining in AI-Driven Drug Discovery by Zhaoxu Meng, Cheng Chen, Xuan Zhang, Wei Zhao, Xuefeng Cui

Subjects: Get full text