A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors by Zarina Nidoieva, Mark O. Sabin, Tristan Dewald, Annabelle C. Weldert, Sabrina N. Hoba, Mark Helm, Fabian Barthels

“…Abstract RNA methyltransferases (MTases) have recently become increasingly important in drug discovery. Yet, most frequently utilized RNA MTase assays are limited in their throughput and hamper this rapidly evolving field of medicinal chemistry. …”
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Fully automated CFD simulation system research based on design scheme tree by Zijun Liu

“…Abstract Compared with the remarkable achievements of computer-aided drug discovery systems for drug discovery, the role of computational fluid dynamics (CFD) in flow channel design requires further development. …”
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Isolation of MDCK cells with low expression of mdr1 gene and their use in membrane permeability screening by BOKULIĆ ANA, PADOVAN JASNA, STUPIN-POLANČEC DARIJA, MILIĆ ASTRID

“…The Madin-Darby canine kidney (MDCK) cell line is frequently used for permeability screening in drug discovery. It contains endogenous transporters, most prominently canine multidrug resistance P-glycoprotein (Mdr1), which can interfere with studies of P-glycoprotein substrate assessment and permeability measurements. …”
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…Given the significance of BBR and its analogs in anti‐gout/hyperuricemia drug discovery, elucidating the mechanism by which BBR exacerbates obesity‐specific DILI warrants further investigation. …”
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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…The journey from drug discovery to approval is often long and expensive, involving multiple stages. …”
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Induction of MASH in three-dimensional bioprinted human liver tissue. by Vaidehi Joshi, Dwayne Carter, Alice E Chen, Keith Murphy, J William Higgins, Mediha Gurel, Daisy Chilin Fuentes, Sara Brin Rosenthal, Kathleen M Fisch, Tatiana Kisseleva, David A Brenner

“…Additionally, the transcriptome of the MASH tissues differed significantly from the healthy tissues and more closely resembled the transcriptome of biopsies of MASH livers from patients Thus, this study has developed a MASH bioprinted liver tissue suitable for studies on pathophysiology and drug discovery.…”
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Technological update for oral health care with blockchain technologies by Chandrabose Selvaraj

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Need for Genome specific personalized medicines in ORAL CANCER? by Chandrabose Selvaraj

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PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…As such, PET imaging has long been used as a tool to aid drug discovery programs from preclinical biomarker validation all the way through to clinical trials. …”
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Dual modality feature fused neural network integrating binding site information for drug target affinity prediction by Haohuai He, Guanxing Chen, Zhenchao Tang, Calvin Yu-Chian Chen

“…Abstract Accurately predicting binding affinities between drugs and targets is crucial for drug discovery but remains challenging due to the complexity of modeling interactions between small drug and large targets. …”
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Proteomics and Its Current Application in Biomedical Area: Concise Review by Semira Gobena, Bemrew Admassu, Mebrie Zemene Kinde, Abebe Tesfaye Gessese

“…Biomedical researchers tirelessly seek cutting-edge technologies to advance disease diagnosis, drug discovery, and therapeutic interventions, all aimed at enhancing human and animal well-being. …”
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DTI-MHAPR: optimized drug-target interaction prediction via PCA-enhanced features and heterogeneous graph attention networks by Guang Yang, Yinbo Liu, Sijian Wen, Wenxi Chen, Xiaolei Zhu, Yongmei Wang

“…Abstract Drug-target interactions (DTIs) are pivotal in drug discovery and development, and their accurate identification can significantly expedite the process. …”
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Nature-Inspired Drugs: Expanding Horizons of Contemporary Therapeutics by Azhar Rasul, Ghulam Hussain, Zeliha Selamoglu, Maria P. López-Alberca

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Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs by Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

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A bird’s-eye view of the biological mechanism and machine learning prediction approaches for cell-penetrating peptides by Maduravani Ramasundaram, Honglae Sohn, Thirumurthy Madhavan

“…Wet lab experiments in drug discovery methodologies are time-consuming and expensive. …”
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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway by Crystal Ngofi Zumbi, Chun-Hsu Pan, Hui-Yu Huang, Chieh-Hsi Wu

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Development of Automated Image Processing for High-Throughput Screening of Potential Anti-Chikungunya Virus Compounds by Pathaphon Wiriwithya, Siwaporn Boonyasuppayakorn, Pattadon Sawetpiyakul, Duangpron Peypala, Gridsada Phanomchoeng

“…Following statistical validation, the algorithm was applied to screen antiviral compounds, demonstrating its effectiveness in enhancing the throughput and accuracy of drug discovery workflows. This technology can be seamlessly integrated into existing virological research pipelines, offering a scalable and efficient tool to accelerate drug discovery and improve diagnostic workflows for vector-borne and emerging viral diseases. …”
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Antimalarial Activity of Piperine by Artitaya Thiengsusuk, Phunuch Muhamad, Wanna Chaijaroenkul, Kesara Na-Bangchang

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Clinical Trials in Chronic Liver Disease - What Do They Achieve? by Jenny Heathcote

“…The past 30 years have seen rapid growth in the number of clinical trials in liver disease; due mostly to effective drug discovery programs by the pharmaceutical industry. …”
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