A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers by Ghanshyam B. Dudhatra, Shailesh K. Mody, Madhavi M. Awale, Hitesh B. Patel, Chirag M. Modi, Avinash Kumar, Divyesh R. Kamani, Bhavesh N. Chauhan

“…In India, Ayurveda has made a major contribution to the drug discovery process with new means of identifying active compounds. …”
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Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model by Yoshiaki Katsuda, Yusuke Kemmochi, Mimi Maki, Ryuhei Sano, Yasufumi Toriniwa, Yukihito Ishii, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta

“…In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.…”
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In Silico and In Vitro Inhibitory Activity of Indonesian Herbal Compound Extracts against SARS-COV-2 Recombinant Papain-Like Protease by Fairuz Andini Fatiningtyas, Riswanto Napitupulu, Amarila Malik, Is Helianti

“… The SARS-CoV-2 papain-like protease (PLpro) is essential for viral replication and a promising target for drug discovery. This study explored the inhibitory potential of compounds from Indonesia herbals Butterfly pea flower (Clitoria ternatea L), Star fruit leaves (Averrhoa carambola L.), and Java plum leaves (Syzygium cumini (L.) …”
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KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning by Huimin Luo, Huimin Luo, Hui Yang, Hui Yang, Ge Zhang, Ge Zhang, Jianlin Wang, Jianlin Wang, Junwei Luo, Chaokun Yan, Chaokun Yan, Chaokun Yan

“…Computational drug repositioning, serving as an effective alternative to traditional drug discovery plays a key role in optimizing drug development. …”
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Genetic Components Derived Parameters and Heterosis in Okra under Saudi Arabia Conditions by Mohamed F. M. Abdelkader, Mohamed H. Mahmoud, Mohamed Z. Diyasty, Noha A. Sukar, Maged I. Farag, Nesma N. I. Mohamed, Yasser A. M. A. Salama, Mohamed A. Abdein

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Anticancer Activity of Holothuria Leucospilota-Derived Saponin on MKN45 Gastric Cancer Cell via Upregulation of CDH1 Hub Gene by Khadijeh Sadegh, Amirhossein Ahmadi, Ahmad Shadi, Ahmad Ghasemi

“…HLBS also upregulated the expression of CDH1, as a highly ranked hub gene associated with GC (P < 0.05).Conclusion: The inhibitory effect of HLBS on MKN45 cells suggests HLBS as a candidate for further drug discovery programs in GC research, and paves the way to introduce new anticancer HLBS synthetic derivatives.…”
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Structural and free energy landscape analysis for the discovery of antiviral compounds targeting the cap-binding domain of influenza polymerase PB2 by Amr S. Abouzied, Saad Alqarni, Kareem M. Younes, Sanad M. Alanazi, Dana M. Alrsheed, Rawabi K. Alhathal, Bader Huwaimel, Akram M. Elkashlan

“…This study aimed to identify and evaluate potential inhibitors of the influenza polymerase PB2 CAP-binding domain using computational drug discovery methods. We employed a comprehensive computational approach involving virtual screening, molecular docking, and 500 ns molecular dynamics (MD) simulations. …”
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Traditional uses, botanical description, phytochemistry, and pharmacological activities of Phytolacca acinosa: a review by Tooba Khalid, Chieh-Wei Chang, Samir Anis Ross, Faiza Naseer, Abdul Qadeer, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Hafiz Abdul Rafey

“…The literature related some of the reported ethnomedicinal uses of the plant to these compounds found in different parts of the plant.ConclusionThe in-depth knowledge about the significance of Phytolacca acinosa presented in this review may open up opportunities for research development in drug discovery and a better comprehension of the therapeutic advantages of the plant.…”
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Computational structure-based design of antiviral peptides as potential protein–protein interaction inhibitors of rabies virus phosphoprotein and human LC8 by Saman Rahmati, Fatemeh Zandi, Khadijeh Ahmadi, Ahmad Adeli, Niloofar Rastegarpanah, Massoud Amanlou, Behrouz Vaziri

“…Despite the successful development of vaccines and efforts made in drug discovery, rabies is incurable. Therefore, development of novel drugs is of interest to the scientific community. …”
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EVALUATION OF ANTIBACTERIAL ACTIVITY OF TRICHILIA DREGEANA SOND (MELIACEAE) CRUDE EXTRACTS AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA by Tesfa Mossie, Temesgen Kasa, Bekesis Urge, Hilena Yifred

“… Medicinal plants have been playing a crucial role in drug discovery and development against infectious diseases. …”
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GS-DTA: integrating graph and sequence models for predicting drug-target binding affinity by Junwei Luo, Ziguang Zhu, Zhenhan Xu, Chuanle Xiao, Jingjing Wei, Jiquan Shen

“…Abstract Background Drug-target binding affinity (DTA) prediction is vital in drug discovery and repositioning, more and more researchers are beginning to focus on this. …”
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DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…These results have pointed out the use of DockCADD as an efficient tool for the fast and low-cost process of drug discovery; L1–L3 should be further validated experimentally for cancer therapy.…”
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Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines by Wei-Yi Lei, Shih-Chieh Hsiung, Shao-Hsuan Wen, Chin-Hsuan Hsieh, Chien-Lin Chen, Christopher Glenn Wallace, Chien-Chung Chang, Shuen-Kuei Liao

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Heterogeneous graph convolutional neural network for protein-ligand scoring by Kevin Crampon, Alexis Giorkallos, Xavier Vigouroux, Stephanie Baud, Luiz Angelo Steffenel

“…Aim: Drug discovery is a long process, often taking decades of research endeavors. …”
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Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice by Kenichi Nakajima, Tomoya Mita, Yusuke Osonoi, Kosuke Azuma, Toshiyuki Takasu, Yoshio Fujitani, Hirotaka Watada

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Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs by Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes

“…Additionally, the compounds were tested on Caenorhabditis elegans, a model organism for drug discovery. All compounds exhibited strong antiparasitic activity, with Cu-phendione showing the greatest potency (EC50 = 2.3 µM for S. mansoni and 6.4 µM for A. cantonensis). …”
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Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation by Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka

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A novel approach for target deconvolution from phenotype-based screening using knowledge graph by Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun

“…Leveraging knowledge graphs and a multidisciplinary approach allows us to streamline the laborious and expensive process of reverse targeting drug discovery through phenotype screening. Our findings have the potential to revolutionize drug screening and open new avenues in pharmacological research, increasing the speed and efficiency of pursuing novel therapeutics. …”
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Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants by Amina Khatun, Mahmudur Rahman, Tania Haque, Md. Mahfizur Rahman, Mahfuja Akter, Subarna Akter, Afrin Jhumur

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SGCL-LncLoc: An Interpretable Deep Learning Model for Improving lncRNA Subcellular Localization Prediction with Supervised Graph Contrastive Learning by Min Li, Baoying Zhao, Yiming Li, Pingjian Ding, Rui Yin, Shichao Kan, Min Zeng

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