The Impact of the Coexpression of MET and ESR Genes on Prognosticators and Clinical Outcomes of Breast Cancer: An Analysis for the METABRIC Dataset by Nehad M. Ayoub, Ghaith M. Al-Taani, Amer E. Alkhalifa, Dalia R. Ibrahim, Aymen Shatnawi

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Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid by Hidetaka Maegawa, Masayuki Kohashi, Yasuo Harada, Akira Tanaka, Shimpei Kajiwara, Takashi Fujimoto, Hidehiro Atagi, Kenta Kaneda

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Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa by Bridget Kamurai, Molly Mombeshora, Stanley Mukanganyama

“…Repurposing of old drugs for the treatment of antimicrobial resistant pathogens has been explored as an alternative strategy in the field of antimicrobial drug discovery. Ten non-antimicrobial compounds were screened for antibacterial activity on two ESKAPE organisms, Staphylococcus aureus and Pseudomonas aeruginosa. …”
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Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach by Debojyoti Halder, Shreya Mukherjee, R. S. Jeyaprakash

“…After extensive literature analysis, it was observed that fragment-based drug discovery, combined with structure-based virtual screening and bioisosteric replacement strategy, could provide a novel way for hit-to-lead optimization. …”
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Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi by Divyapriya Karthikeyan, Sanjit Kumar, NS Jayaprakash

“…This study illustrates how computational techniques, such as MD simulations and pharmacophore modeling, can speed up drug discovery, especially in the fight against antibiotic resistance.…”
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High-Yield Generation of Glucose-Responsive Pseudoislets From Murine Insulinoma Cells for Studies and Longitudinal Monitoring of Graft Survival by Grisell C. Gonzalez, Chris M. Li, Ilaria Pasolini, Sophia I. Pete, Connor Verheyen, Sofia M. Vignolo, Teresa De Toni, Aaron A. Stock, Alice A. Tomei

“…Overall, this platform provides an accessible protocol for generating high yields of 3D pseudoislets and non-invasive longitudinal monitoring of graft survival in different models offer advantages over primary islets for optimization and mechanistic studies of β cell biology, drug discovery, T1D pathogenesis and prevention, and β cell transplantation.…”
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Proteomic Characterization of Liver Cancer Cells Treated with Clinical Targeted Drugs for Hepatocellular Carcinoma by Hezhou Long, Jiafu Zhou, Changxia Zhou, Shuyu Xie, Jingling Wang, Minjia Tan, Junyu Xu

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Transforming precision medicine: The potential of the clinical artificial intelligent single‐cell framework by Christian Baumgartner, Dagmar Brislinger

“…Future applications of caiSC could include digital cell twins, offering in‐depth simulations of cellular behavior to support drug discovery and personalized treatments. Regulatory considerations are discussed, underscoring the need for SaMD/AIaMD certifications for clinical use. …”
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Quantitation of Phenolic Compounds Related to Antioxidant and Antiosteoporosis Activities in Ripe and Unripe Maesil (Prunus mume) by Chong Woon Cho, Young Sik Park, Xi-Tao Yan, Hyun June Kim, Young Ho Kim, Kyung Tae Kim, Chu Van Men, Jong Seong Kang

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Evaluating translational science knowledge gains following an online short course for a general scientific audience by Amanda L. Vogel, Shadab F. Hussain, Jessica M. Faupel-Badger

“…Students reported the course helped them learn about the trajectory of a drug discovery and development initiative, where their own work fit in, and scientific and operational approaches to apply in their own work. …”
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Isolation and Bioactivity of Natural Products from <i>Streptomyces</i> sp. MA37 by Fleurdeliz Maglangit, Qing Fang, Jioji N. Tabudravu, Kwaku Kyeremeh, Marcel Jaspars, Hai Deng

“…The isolation and characterization of bioactive metabolites from <i>Streptomyces</i> species continue to represent a vital area of research, given their potential in natural product drug discovery. In this study, we characterize a new siderophore called legonoxamine I, together with a known compound, streptimidone, from the talented soil bacterium <i>Streptomyces</i> sp. …”
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Advances in the Development and Application of Human Organoids: Techniques, Applications, and Future Perspectives by Zhangcheng Zhu, Yiwen Cheng, Xia Liu, Wenwen Ding, Jiaming Liu, Zongxin Ling, Lingbin Wu

“…This progress has expanded their application across several domains, including regenerative medicine, where organoids offer potential for tissue replacement and repair; disease modeling, which allows for the study of disease mechanisms and progression in a controlled environment; drug discovery and evaluation, where organoids provide a more accurate platform for testing drug efficacy and safety; and microecological research, where they contribute to understanding the interactions between microbes and host tissues. …”
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Antioxidant, Antimicrobial, and Protein Kinase Inhibition Profiling of C. ambrosioides Seed Extracts along with RP-HPLC by Saira Bano, Muhammad Waleed Baig, Mohammad K. Okla, Syeda Saniya Zahra, Nosheen Akhtar, Wahidah H. Al-Qahtani, Hamada AbdElgawad, Ihsan-Ul Haq

“…The validation of underexplored traditional plant remedies represents a reservoir of novel leads for drug discovery. In line with this, in vitro total phenolics and flavonoids content, multimode antioxidants, antimicrobial, cytotoxicity, and protein kinase inhibition assays were conducted on C. ambrosioides seed extracts in addition to RP-HPLC. …”
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The algebraic extended atom-type graph-based model for precise ligand–receptor binding affinity prediction by Farjana Tasnim Mukta, Md Masud Rana, Avery Meyer, Sally Ellingson, Duc D. Nguyen

“…The AGL-EAT-Score marks a significant advancement in drug design, offering a tool that could potentially refine and accelerate the drug discovery process. Scientific Contribution The AGL-EAT-Score presents an algebraic graph-based framework that predicts ligand-receptor binding affinity by constructing multiscale weighted colored subgraphs from the 3D structure of protein-ligand complexes. …”
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Molecular Characterization and Antibacterial Potential of Endophytic Fungal Isolates from Selected Mangroves along the Coastline of Kenya by Teresia Nyambura Wacira, Huxley Mae Makonde, Carren Moraa Bosire, Cromwell Mwiti Kibiti

“…It is recommended that the pure compounds from these extracts be isolated for further bioactivity tests and structural elucidation for consideration as lead molecules in drug discovery. In addition, the genes responsible for the enhanced bioactivity in these isolates can be characterized and bioengineered for pharmaceutical application.…”
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Novel tetracycline hybrids: synthesis, characterization, docking studies and in-vitro evaluation of antibacterial activity by Mansi Shah, Bhanubhai Suhagia, Sunita Goswami, Sneha Sagar, Arpit Patwari

“…These hybrids can serve as a promising lead compound for antibiotic drug discovery.…”
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InceptionDTA: Predicting drug-target binding affinity with biological context features and inception networks by Mahmood Kalemati, Mojtaba Zamani Emani, Somayyeh Koohi

“…Predicting drug-target binding affinity via in silico methods is crucial in drug discovery. Traditional machine learning relies on manually engineered features from limited data, leading to suboptimal performance. …”
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Girolline is a sequence context-selective modulator of eIF5A activity by Tilman Schneider-Poetsch, Yongjun Dang, Wakana Iwasaki, Mayumi Arata, Yuichi Shichino, Ali Al Mourabit, Celine Moriou, Daniel Romo, Jun O. Liu, Takuhiro Ito, Shintaro Iwasaki, Minoru Yoshida

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Explication of Pharmacological Proficiency of Phytoconstituents from Adansonia digitata Bark: An In Vitro and In Silico Approaches by Sangavi P., Gowtham Kumar S., Nachammai KT., Chandrabose Selvaraj, Langeswaran K.

“…Compared to other drug discovery sources, traditional medicine has significantly contributed to developing innovative therapeutic molecules for preventive and curative medicine. …”
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System Pharmacological Approach to Investigate and Validate Multitargeted and Therapeutic Effect of Furocoumarins of Apium graveolens L. for Treatment of Kidney Disease by null Yasheshwar, null Gaurav, Rustam Ekkbal, Prem Gupta, Rajendra Gyawali

“…System pharmacological approaches play important roles in drug discovery and development and in biomolecular exploration to investigate the multitarget therapeutic effects of phytochemicals for the treatment of acute and chronic ailments. …”
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