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SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model
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Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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183
Chimie des substances naturelles et pharmacie : à la croisée des chemins
Published 2024-04-01“…An overview of the importance of natural products in pharmacy and drug discovery is provided herein. This “account” article seeks to shed light on current issues and challenges, through a critical analysis ranging from bioprospecting to the marketing of new drugs.…”
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Cannabinoid receptor 2 facilitates the Schwann cells‐dependent peripheral nerve regeneration
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Anti-Quorum Sensing in Pathogenic Microbes Using Plant-Based Bioactive Phytochemicals
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188
Protocol to develop A 3D tumor model for drug testing applications
Published 2025-01-01“…Three-dimensional (3D) tumor models provide physiologically relevant tumor environments and have become a major tool in cancer research and drug discovery. This article presents a protocol for creating a 3D organotypic tumor model by embedding a cancer cell spheroid within a collagen matrix containing dispersed fibroblasts. …”
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Network-assisted target identification for haploinsufficiency and homozygous profiling screens.
Published 2017-06-01“…Chemical genomic screens have recently emerged as a systematic approach to drug discovery on a genome-wide scale. Drug target identification and elucidation of the mechanism of action (MoA) of hits from these noisy high-throughput screens remain difficult. …”
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Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model
Published 2025-01-01“…Notably, artificial intelligence (AI) technologies have significantly advanced drug discovery. This study aimed to discover RIPK3 inhibitor with AI assistance. …”
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Syntheses and Antibacterial Studies of Some 1-Phenyl-3-(4-(2-ethanoloxy) phenyl)-5-aryl-1H-pyrazoles
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195
Application of DNA Array Technology for Diagnostic Microbiology
Published 2000-01-01“…Microarrays or DNA chips have been hailed as the ultimate experimental tool for research, drug discovery and diagnostics. They have the potential to perform a multitude of molecular tests simultaneously and to produce a wealth of information from a single clinical sample. …”
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Molecular optimization using a conditional transformer for reaction-aware compound exploration with reinforcement learning
Published 2025-02-01“…Abstract Designing molecules with desirable properties is a critical endeavor in drug discovery. Because of recent advances in deep learning, molecular generative models have been developed. …”
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COMPUTAÇÃO QUÂNTICA EM QUÍMICA
Published 2025-01-01“…These collaborations pave the way for groundbreaking advancements in drug discovery and materials science. This research employed quantum computing simulators to investigate the potential energy surface (PES) of the H2 molecule at the CCSD/STO-3G level of theory. …”
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198
Harnessing 3D models to uncover the mechanisms driving infectious and inflammatory disease in the intestine
Published 2024-12-01“…Here, we describe the latest platforms engineered to investigate environmental tissue impacts, host-microbe interactions and enable drug discovery. This highlights the potential to revolutionise knowledge on the impact of intestinal infection and inflammation and enable personalised disease modelling and clinical translation.…”
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A Review on Mangrove Actinobacterial Diversity: The Roles of Streptomyces and Novel Species Discovery
Published 2019-05-01“…The significant contribution of Streptomyces in microbial drug discovery as witnessed through the discovery of many important antibiotic drugs has undeniably encourage the exploration of these bacteria from different environments, especially the mangrove environments. …”
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