Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs by Xing Wan, Jingyuan Ma, He Bai, Xuyang Hu, Yanna Ma, Mingjian Zhao, Jifeng Liu, Zhijun Duan

“…In recent years, progress has been made in understanding the pathogenesis of NAFLD, identifying multiple therapeutic targets and providing new directions for drug development. This review summarizes the recent advances in the treatment of NAFLD, focusing on the mechanisms of action of natural products, small-synthetic-molecule drugs, and combination therapy strategies. …”
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Acoustic bubbles: Inducing cell interactions via trapping, patterning, and removal by Jonathan Faulkner, Mengren Wu, Madelyn Wicker, Yuan Gao

“…Studying cell-cell interactions is crucial for understanding biological processes and advancing drug development. Recent advancements in microfluidic technology allow cell-cell interaction experiments to be performed on-chip, enabling the study of specific interactions within a highly defined microenvironment. …”
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Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases by Huang X, Yu W, Wei A, Wang X, Chen S

“…We highlight their potential as biomarkers and therapeutic targets, offering promising avenues for drug development in these debilitating respiratory disorders. …”
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Cricoid chondroma presenting as upper airway obstruction: A report of a rare case by Samuel Sisay Hailu, MD, Eyoel Degafu, MD, Tequam Debebe, MD, Yonas Shumiye, MD, Bizunesh Dires, MD, Bethlehem Tesfasilassie Kibrom, MD

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MCF-DTI: Multi-Scale Convolutional Local–Global Feature Fusion for Drug–Target Interaction Prediction by Jihong Wang, Ruijia He, Xiaodan Wang, Hongjian Li, Yulei Lu

“…These findings contribute valuable insights for subsequent drug repurposing efforts and novel drug development.…”
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Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors... by Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchir, Yasir S Raouf, Dhabya Bakhit Albalushi, Abdelouahid Samadi, Samir Chtita

“…These findings identify molecules 14c and 17c as promising multi-target candidates for the treatment of AD, based on an in-depth computational study aimed at minimizing drug development costs and time. Future work will include the synthesis of these molecules followed by in-depth in vitro and in vivo testing to validate their potential therapeutic efficacy.…”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…A major challenge in the drug development process is drug-induced liver injury (DILI), a condition that affects the liver, the organ responsible for metabolizing most drugs. …”
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Identification of Novel LCN2 Inhibitors Based on Construction of Pharmacophore Models and Screening of Marine Compound Libraries by Fragment Design by Ningying Zheng, Xuan Li, Nan Zhou, Lianxiang Luo

“…MM-PBSA analysis revealed key amino acid residues that are involved in interactions, suggesting that Compound 69081_50 could be a candidate for drug development.…”
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Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults by Iftekhar Mahmood

“…The estimated absolute bioavailability in children could be useful in designing a first-in-children dose during pediatric drug development.…”
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GSK-3𝜷: A Bifunctional Role in Cell Death Pathways by Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry J. Jaboin, Dennis E. Hallahan, Dinesh Thotala

“…GSK-3β has emerged as an important molecular target for drug development.…”
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ISLRWR: A network diffusion algorithm for drug-target interactions prediction. by Lu Sun, Zhixiang Yin, Lin Lu

“…Machine learning techniques and computer-aided methods are now widely used in the pre-discovery tasks of drug discovery, effectively improving the efficiency of drug development and reducing the workload and cost. In this study, we used multi-source heterogeneous network information to build a network model, learn the network topology through multiple network diffusion algorithms, and obtain compressed low-dimensional feature vectors for predicting drug-target interactions (DTIs). …”
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Algorithm and Simulation of Association Rules of Drug Relationship Based on Network Model by Hui Teng, Yukun Ma, Di Teng

“…Studying drug relationships can provide deeper information for the construction and maintenance of biomedical databases and provide more important references for disease treatment and drug development. The research model has expanded from the previous focus on a certain drug to the systematic analysis of the pharmaceutical network formed between drugs. …”
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Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i> by Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

“…This study focuses on the NS2B-NS3 protease as a promising target for antiviral drug development. Promising allosteric binding sites were identified in two conformationally distinct inactive states and characterized for five flaviviruses and four Dengue virus subtypes. …”
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Longitudinal genomic profiling using liquid biopsies in metastatic nonsquamous NSCLC following first line immunotherapy by Haolun Ding, Min Yuan, Yaning Yang, Xu Steven Xu

“…Overall, longitudinal liquid biopsy profiling provided valuable insights into lung cancer biology post-immunotherapy, potentially guiding personalized therapies and future drug development.…”
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Stem Cells as In Vitro Model of Parkinson's Disease by Patricia L. Martínez-Morales, Isabel Liste

“…The ability to generate induced pluripotent stem cells (iPSCs) from PD patients and a refined capacity to differentiate these iPSCs into DA neurons, the relevant disease cell type, promises a new paradigm in drug development that positions human disease pathophysiology at the core of preclinical drug discovery. …”
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Biological Effects of Culture Substrates on Human Pluripotent Stem Cells by Yohei Hayashi, Miho Kusuda Furue

“…Understanding the role of culture substrates in hPSC self-renewal and differentiation enables us to control hPSC behavior precisely and to establish scalable or microfabricated culture technologies for regenerative medicine and drug development.…”
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Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation by Zhaoshan Zhang, Jiawei Guo

“…Second, it summarizes the cardiovascular protective effects, mechanisms of action, and animal models of various antioxidants, offering insights into future drug development. Third, it discusses the applications, advantages, limitations, and potential molecular targets of gene therapy in CVDs, providing a foundation for novel therapeutic strategies. …”
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Reductive sulfinylation by nucleophilic chain isomerization of sulfonylpyridinium by Yifan Li, Weigang Zhang, Jeonguk Kweon, Yi Pan, Qing Wang, Sukbok Chang, Yi Wang

“…The synthesis of sulfinate esters and sulfinamides has garnered significant interest owing to their immense potential for applications, especially in drug development. However, most existing synthetic protocols suffer from some limitations. …”
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Complete Whole-Genome Sequence of Streptomyces sp. MUM 178J, a Potential Anti-Vibrio Agent by Ke-Yan Loo, Loh Teng-Hern Tan, Kah-Ooi Chua, Priyia Pusparajah, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law, Vengadesh Letchumanan

“… Streptomyces sp. is a group of filamentous, Gram-positive bacteria notoriously known for their capabilities in producing bioactive compounds that have been used as novel drugs and lead in drug development. The Streptomyces sp. MUM 178J was isolated from a mangrove forest in Malaysia. …”
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From Lab to Clinic: Effect of Academia–Industry Collaboration Characteristics on Oncology Phase 1 Trial Entry by Wonseok Yang, Sang‐Won Lee

“…This study sheds light on how the characteristics of partnerships influence the success rates of early‐phase research, providing valuable insights for future strategic planning in oncology drug development.…”
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