Stem Cells as In Vitro Model of Parkinson's Disease by Patricia L. Martínez-Morales, Isabel Liste

“…The ability to generate induced pluripotent stem cells (iPSCs) from PD patients and a refined capacity to differentiate these iPSCs into DA neurons, the relevant disease cell type, promises a new paradigm in drug development that positions human disease pathophysiology at the core of preclinical drug discovery. …”
Get full text

Biological Effects of Culture Substrates on Human Pluripotent Stem Cells by Yohei Hayashi, Miho Kusuda Furue

“…Understanding the role of culture substrates in hPSC self-renewal and differentiation enables us to control hPSC behavior precisely and to establish scalable or microfabricated culture technologies for regenerative medicine and drug development.…”
Get full text

Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation by Zhaoshan Zhang, Jiawei Guo

“…Second, it summarizes the cardiovascular protective effects, mechanisms of action, and animal models of various antioxidants, offering insights into future drug development. Third, it discusses the applications, advantages, limitations, and potential molecular targets of gene therapy in CVDs, providing a foundation for novel therapeutic strategies. …”
Get full text

Complete Whole-Genome Sequence of Streptomyces sp. MUM 178J, a Potential Anti-Vibrio Agent by Ke-Yan Loo, Loh Teng-Hern Tan, Kah-Ooi Chua, Priyia Pusparajah, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law, Vengadesh Letchumanan

“… Streptomyces sp. is a group of filamentous, Gram-positive bacteria notoriously known for their capabilities in producing bioactive compounds that have been used as novel drugs and lead in drug development. The Streptomyces sp. MUM 178J was isolated from a mangrove forest in Malaysia. …”
Get full text

From Lab to Clinic: Effect of Academia–Industry Collaboration Characteristics on Oncology Phase 1 Trial Entry by Wonseok Yang, Sang‐Won Lee

“…This study sheds light on how the characteristics of partnerships influence the success rates of early‐phase research, providing valuable insights for future strategic planning in oncology drug development.…”
Get full text

Drug-Gene Interaction Prediction Method through Cross Granularity Subgraph Contrastive Learning and Attention Mechanism Fusion by HU Dongdong, PENG Yang, TAN Shuqiu, ZHU Xiaofei

“…[Purposes] Clarifying the interconnections between drugs and genes is an important topic in drug development. At present, the graph neural network method based on the random walk algorithm has achieved great results in identifying drug-gene interaction relationships. …”
Get full text

Exploration of Potent Human α-Glucosidase Inhibitors Using In Silico Approaches: Molecular Docking, DFT, Molecular Dynamics Simulations, and MMPBSA by Jyoti Bashyal, Bimal Kumar Raut, Siddha Raj Upadhyaya, Kabita Sharma, Niranjan Parajuli

“…These findings highlight their promise for future drug development targeting α-glucosidase inhibition in diabetes management; however, more research needs to be conducted.…”
Get full text

In Vitro and In Silico Analysis of Bergenia ciliata and Mimosa pudica for Inhibition of α-Amylase by Mahesh Bohara, Sajani Ghaju, Kabita Sharma, Surya Kant Kalauni, Karan Khadayat

“…Various medicinal plants with diverse chemical constituents have been extensively studied for drug development. Bergenia ciliata and Mimosa pudica have been traditionally used for the treatment of diabetes and consist of valuable phytochemicals. …”
Get full text

Adipokines as Drug Targets in Diabetes and Underlying Disturbances by Vinícius Andrade-Oliveira, Niels O.S. Câmara, Pedro M. Moraes-Vieira

“…We also survey current attempts to exploit adipokines for clinical applications, which hold potential as novel approaches to drug development in several immune-mediated diseases.…”
Get full text

Comprehensive evaluation of pure and hybrid collaborative filtering in drug repurposing by Clémence Réda, Jill-Jênn Vie, Olaf Wolkenhauer

“…Abstract Drug development is known to be a costly and time-consuming process, which is prone to high failure rates. …”
Get full text

MORF: Multi-view oblique random forest for hepatotoxicity prediction by Binsheng Sui, Qingzhuo He, Bowei Yan, Kunhong Liu, Yong Xu, Song He, Xiaochen Bo

“…Summary: Hepatotoxicity prediction is significant in drug development, so the experts expect to get effective and reliable references. …”
Get full text

Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids by Leah Liu Wang, Javier Seravalli, Brett Eaton, Yi Liu, Michael R. Holbrook, Wen-Jian Lan, Shi-Hua Xiang

“…Since marine indole alkaloids comprise a large diverse group of secondary metabolites, their biological properties would be helpful for pharmaceutical drug development to treat various filovirus infections.…”
Get full text

AVP-GPT2: A Transformer-Powered Platform for De Novo Generation, Screening, and Explanation of Antiviral Peptides by Huajian Zhao, Gengshen Song

“…Future research will explore its application to other viral targets and its integration into existing drug development pipelines.…”
Get full text

Synthesis and crystal structure of (S,E)-4-hydroxy-3-(2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)ethylidene)dihydrofura... by Li Shi-Qing, Zhou Jian, Dong Zhang-Chao, Pan Bo Wen, Shi Yang, Zhou Ying

Get full text

Detection of Garlic Powder Adulteration Using FTIR Spectroscopy and Chemometrics: A Case Study in an Indonesia Marketplace by Avika Rizky Elvira, Anggita Rosiana Putri, Luthfi Ahmad Muchlashi

Get full text

Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model by Toshiki Goto, Akira Sano, Shinichi Onishi, Natsuko Hada, Rui Kimata, Saori Matsuo, Sohei Oyama, Atsuhiko Kato, Hideaki Mizuno, Masaki Yamazaki

“…This deep learning-based fibrosis grade assessment has the potential to streamline drug development for pulmonary fibrosis by offering higher granularity and reproducibility in evaluating BLM model.…”
Get full text

SARS-CoV-2 drug resistance and therapeutic approaches by Sania Batool, Santosh Chokkakula, Ju Hwan Jeong, Yun Hee Baek, Min-Suk Song

“…By examining the complex interactions between the virus and its host, the review advocates for a multifaceted approach, including combination therapies, targeted drug development, and continuous surveillance of viral mutations. …”
Get full text

Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

“…A deeper understanding of the molecular underpinnings of EBV's influence on cell death not only enriches the field of viral oncology but also pinpoints targets for drug development. Furthermore, the insights gleaned from this review could catalyze the design of vaccines aimed at preventing EBV infection or curtailing its oncogenic impact. …”
Get full text

Assessing traditional Chinese medicine from a molecular perspective by Minhui Su, Wenxi Wang, Xudong Sun, Lihong Li, Weihong Tan

“…Nucleic acids, a class of star functional molecules, are notable for their versatile applications in molecular diagnostics, gene therapy, and drug development. Therefore, in this study, we review the extensive use of nucleic acid aptamers in medicinal practice. …”
Get full text

In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase by Rishab Marahatha, Asmita Shrestha, Kabita Sharma, Bishnu P. Regmi, Khaga Raj Sharma, Pramod Poudel, Ram Chandra Basnyat, Niranjan Parajuli

“…While there have been some vaccines and drugs, the rapid emergence of variants due to mutations has threatened public health. As the de novo drug development process is expensive and time-consuming, repurposing existing antiviral drugs against SARS-CoV-2 is an alternative and promising approach to mitigate the current situation. …”
Get full text