Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…Consequently, understanding the cellular mechanisms underlying HIF activation and its downstream effects has become crucial to developing targeted cancer therapies for improving cancer patient outcomes and represents a key step towards precision medicine.Recent advancements in drug development have led to the emergence of HIF inhibitors, which aim to disrupt HIF-driven processes in cancer providing therapeutic benefit. …”
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Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies by Michael A. Partridge, Shobha Purushothama, Chinnasamy Elango, Yanmei Lu

“…It is critical to assess the immunogenicity risk of potential biotherapeutics in producing neutralizing and nonneutralizing anti-drug antibodies, especially in clinical phases of drug development. Different assay methodologies have been used to detect all anti-drug antibodies, including ELISA, radioimmunoassay, surface plasmon resonance, and electrochemiluminescence-based technologies. …”
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Molecular Imaging in Tumor Angiogenesis and Relevant Drug Research by Xibo Ma, Jie Tian, Xin Yang, Chenghu Qin

“…Tumor angiogenesis and relevant drug development is a lengthy, high-risk, and costly process, in which a novel drug needs about 10–15 years of testing to obtain Federal Drug Association (FDA) approval. …”
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The Therapeutic Potential of Medicinal Foods by Nelvana Ramalingum, M. Fawzi Mahomoodally

“…The potential challenges of incorporating these medicinal foods in the diet which offers prospective opportunities for future drug development are also discussed.…”
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Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…Future research is expected to focus on drug development and clinical applications. This comprehensive bibliometric analysis provides clinical insights and a guide for further investigation to STING agonist/inhibitor.…”
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Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress by Robert Fürst, Ilse Zündorf

“…Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Also, nowadays, new plant-derived agents continuously enrich our drug arsenal (e.g., vincristine, galantamine, and artemisinin). …”
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Harnessing the AI/ML in Drug and Biological Products Discovery and Development: The Regulatory Perspective by Fahimeh Mirakhori, Sarfaraz K. Niazi

“…Artificial Intelligence (AI) has the disruptive potential to transform patients’ lives via innovations in pharmaceutical sciences, drug development, clinical trials, and manufacturing. However, it presents significant challenges, ethical concerns, and risks across sectors and societies. …”
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Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs by Xing Wan, Jingyuan Ma, He Bai, Xuyang Hu, Yanna Ma, Mingjian Zhao, Jifeng Liu, Zhijun Duan

“…In recent years, progress has been made in understanding the pathogenesis of NAFLD, identifying multiple therapeutic targets and providing new directions for drug development. This review summarizes the recent advances in the treatment of NAFLD, focusing on the mechanisms of action of natural products, small-synthetic-molecule drugs, and combination therapy strategies. …”
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Acoustic bubbles: Inducing cell interactions via trapping, patterning, and removal by Jonathan Faulkner, Mengren Wu, Madelyn Wicker, Yuan Gao

“…Studying cell-cell interactions is crucial for understanding biological processes and advancing drug development. Recent advancements in microfluidic technology allow cell-cell interaction experiments to be performed on-chip, enabling the study of specific interactions within a highly defined microenvironment. …”
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Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases by Huang X, Yu W, Wei A, Wang X, Chen S

“…We highlight their potential as biomarkers and therapeutic targets, offering promising avenues for drug development in these debilitating respiratory disorders. …”
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Cricoid chondroma presenting as upper airway obstruction: A report of a rare case by Samuel Sisay Hailu, MD, Eyoel Degafu, MD, Tequam Debebe, MD, Yonas Shumiye, MD, Bizunesh Dires, MD, Bethlehem Tesfasilassie Kibrom, MD

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MCF-DTI: Multi-Scale Convolutional Local–Global Feature Fusion for Drug–Target Interaction Prediction by Jihong Wang, Ruijia He, Xiaodan Wang, Hongjian Li, Yulei Lu

“…These findings contribute valuable insights for subsequent drug repurposing efforts and novel drug development.…”
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Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors... by Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchir, Yasir S Raouf, Dhabya Bakhit Albalushi, Abdelouahid Samadi, Samir Chtita

“…These findings identify molecules 14c and 17c as promising multi-target candidates for the treatment of AD, based on an in-depth computational study aimed at minimizing drug development costs and time. Future work will include the synthesis of these molecules followed by in-depth in vitro and in vivo testing to validate their potential therapeutic efficacy.…”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…A major challenge in the drug development process is drug-induced liver injury (DILI), a condition that affects the liver, the organ responsible for metabolizing most drugs. …”
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Identification of Novel LCN2 Inhibitors Based on Construction of Pharmacophore Models and Screening of Marine Compound Libraries by Fragment Design by Ningying Zheng, Xuan Li, Nan Zhou, Lianxiang Luo

“…MM-PBSA analysis revealed key amino acid residues that are involved in interactions, suggesting that Compound 69081_50 could be a candidate for drug development.…”
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Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults by Iftekhar Mahmood

“…The estimated absolute bioavailability in children could be useful in designing a first-in-children dose during pediatric drug development.…”
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GSK-3𝜷: A Bifunctional Role in Cell Death Pathways by Keith M. Jacobs, Sandeep R. Bhave, Daniel J. Ferraro, Jerry J. Jaboin, Dennis E. Hallahan, Dinesh Thotala

“…GSK-3β has emerged as an important molecular target for drug development.…”
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ISLRWR: A network diffusion algorithm for drug-target interactions prediction. by Lu Sun, Zhixiang Yin, Lin Lu

“…Machine learning techniques and computer-aided methods are now widely used in the pre-discovery tasks of drug discovery, effectively improving the efficiency of drug development and reducing the workload and cost. In this study, we used multi-source heterogeneous network information to build a network model, learn the network topology through multiple network diffusion algorithms, and obtain compressed low-dimensional feature vectors for predicting drug-target interactions (DTIs). …”
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Algorithm and Simulation of Association Rules of Drug Relationship Based on Network Model by Hui Teng, Yukun Ma, Di Teng

“…Studying drug relationships can provide deeper information for the construction and maintenance of biomedical databases and provide more important references for disease treatment and drug development. The research model has expanded from the previous focus on a certain drug to the systematic analysis of the pharmaceutical network formed between drugs. …”
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Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i> by Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

“…This study focuses on the NS2B-NS3 protease as a promising target for antiviral drug development. Promising allosteric binding sites were identified in two conformationally distinct inactive states and characterized for five flaviviruses and four Dengue virus subtypes. …”
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