Cigarette smoke compromises macrophage innate sensing in response to pneumococcal infection by Wei-Chih Liao, Chia-Huei Chou, Mao-Wang Ho, Jo-Tsen Chen, Shu-Ling Chou, Yu-Tsen Huang, Ngoc-Niem Bui, Hui-Yu Wu, Chi-Fan Lee, Wei-Chien Huang, Chih-Ho Lai

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Leaflet: Operative Steps for Interventional Studies in Neuroscience by Maria Meringolo, Sergio Delle Monache, Giuseppina Martella, Antonella Peppe

“…Background/Objectives: Drug development involves multiple stages, spanning from initial discovery to clinical trials. …”
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Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective by Wenhao Liao, Jing Wang, Yuchen Li

“…Natural products (NPs) have been an important source for drug development due to abundant sources, tremendous safety, and multiple pharmacodynamic mechanisms. …”
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Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease by John L Wallace

“…In each case, evidence is presented from clinical and/or experimental studies that supports the hypothesis that these are rational targets for anti-inflammatory drug development.…”
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Antiepileptic activity and potential mechanism of full-spectrum hemp extract by Zengliang Jin, Zhuo Huang

“…This article not only presents the great potential of HE as a candidate for new anti-epileptic drugs with less psychoactive, but also provides a valuable contribution to subsequent mechanism research and drug development on epilepsy.…”
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Promising LOX proteins for cartilage-targeting osteoarthritis therapy by Luca Morici, Eric Allémann, Olivier Jordan, Ines Nikolić

“…This review, therefore, proposes promising strategies for future drug development in OA treatment.…”
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Mechanisms of Copper-Induced Autophagy and Links with Human Diseases by Yuanyuan Fu, Shuyan Zeng, Zhenlin Wang, Huiting Huang, Xin Zhao, Min Li

“…Since the success of platinum-based compounds in the clinical treatment of various types of neoplasias, metal-based drugs have shown encouraging perspectives for drug development. Compared to platinum, copper is an essential intracellular trace element that may have better prospects for drug development than platinum. …”
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A novel approach for target deconvolution from phenotype-based screening using knowledge graph by Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun

“…Abstract Deconvoluting drug targets is crucial in modern drug development, yet both traditional and artificial intelligence (AI)-driven methods face challenges in terms of completeness, accuracy, and efficiency. …”
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Mutation Analysis of Synthetic DNA Barcodes in a Fission Yeast Gene Deletion Library by Sanger Sequencing by Minho Lee, Shin-Jung Choi, Sangjo Han, Miyoung Nam, Dongsup Kim, Dong-Uk Kim, Kwang-Lae Hoe

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Reversal gene expression assessment for drug repurposing, a case study of glioblastoma by Shixue Sun, Zeenat Shyr, Kathleen McDaniel, Yuhong Fang, Dingyin Tao, Catherine Z. Chen, Wei Zheng, Qian Zhu

“…Conclusions The success of this study illustrated a promising avenue for accelerating drug development by uncovering underlying gene expression effect between drugs and diseases, which can be extended to other rare diseases and non-rare diseases.…”
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Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial by Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke, Shigeyuki Tahara, Gudmundur Johannsson

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Identification of a binding site for small molecule inhibitors targeting human TRPM4 by Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel, Dongchun Ni

“…Our structural data and results from patch clamp experiments enable validation of a binding site for small molecule inhibitors, paving the way for further drug development targeting TRPM4.…”
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Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives by Chenchen Shi, Haipeng Li, Yifu Yang, Lifei Hou

“…In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions.…”
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Chemical Application of Topological Indices in Infertility Treatment Drugs and QSPR Analysis by Sobia Sultana

“…Chemical graph theory makes an important theoretical contribution to drug development and design by investigating the structural properties of molecules. …”
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DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…These findings signify a significant stride towards more accurate and efficient drug development methodologies.…”
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A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging by Cheng Yao, Ruwei Wei, Xiao Luo, Jie Zhou, Xiaodong Zhang, Xicun Lu, Yan Dong, Ruofan Chu, Yuxin Sun, Yu Wang, Wencheng Xia, Dahui Qu, Cong Liu, Jun Ren, Guangbo Ge, Jinquan Chen, Xuhong Qian, Youjun Yang

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Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trialsResearch in context by Yue Zhao, Zuguo Zheng, Xuexiao Jin, Shaoshan Liang, Changming Zhang, Mingchao Zhang, Yue Lang, Ping Li, Zhihong Liu

“…This strategy could accelerate drug development and clinical translation processes for LN. …”
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Progress of Clinical Research on Trop2 in Solid Tumors by Ying ZHANG, Yueping LIU

“…In this review, we comprehensively discuss the gene structure, mechanism of action, clinical research, drug development, and other aspects of Trop2 to provide references for the clinical development of effective and safe Trop2-targeting drugs.…”
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Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy by Parvin F. Peddi, Matthew J. Ellis, Cynthia Ma

“…Understanding the molecular basis of triple negative breast cancer is crucial for effective new drug development. Recent genomewide gene expression and DNA sequencing studies indicate that this cancer type is composed of a molecularly heterogeneous group of diseases that carry multiple somatic mutations and genomic structural changes. …”
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