Pharma TARP: A Troubled Asset Relief Program for Novel, Abandoned Projects in the Pharmaceutical Industry by Tamas Bartfai, Graham Vaughan Lees

“…Pfizer alone will close well over a hundred drug development projects that have reached two-thirds of the way to launch. …”
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Designing an exploratory phase 2b platform trial in NASH with correlated, co-primary binary endpoints. by Elias Laurin Meyer, Peter Mesenbrink, Nicholas A Di Prospero, Juan M Pericàs, Ekkehard Glimm, Vlad Ratziu, Elena Sena, Franz König, EU-PEARL NASH Investigators

“…Platform trials provide great benefits for sponsors and trial participants in terms of accelerating drug development programs. In this article, we describe some of the activities of the EU-PEARL consortium (EU Patient-cEntric clinicAl tRial pLatforms) regarding the use of platform trials in NASH, in particular the proposed trial design, decision rules and simulation results. …”
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The Use of Generic Medications for Glaucoma by Andrew J. Tatham

“…Other potential problems with generic eye drops include differences in bottle design affecting adherence, problems with supply, and the possibility that reduced revenue for innovator companies will lead to reduced investment in new drug development. This article reviews the potential advantages and disadvantages of generic antiglaucoma medications.…”
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Interactions between Bacteriophages and Eukaryotic Cells by Ramendra Dirgantara Putra, Diana Lyrawati

“…With the advancement and combination of in silico, in vitro, and in vivo approaches and clinical trials, bacteriophages definitely serve as useful repertoire for biologic target-based drug development to manage many complex diseases in the future.…”
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Intestinal inflammation in TNBS sensitized rats as a model of chronic inflammatory bowel disease by N. Selve, T. Wöhrmann

“…The applicability and relevance of this new model are discussed with respect to drug development and basic research of inflammatory bowel diseases.…”
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A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol by Lei Zhang, Yuqing Tian, Lingling Zhang, Huanyu Zhang, Jinghua Yang, Yi Wang, Na Lu, Wei Guo, Liang Wang

“…Additionally, we explored the pharmacokinetics, toxicology, and drug development aspects of Syringaresinol to guide future research efforts. …”
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Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis by Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

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Digital Twins of Biological Systems: A Narrative Review by Ghufran A. Alsalloum, Nour M. Al Sawaftah, Kelly M. Percival, Ghaleb A. Husseini

“…The influence of DTs extends beyond healthcare and can revolutionize healthcare management, drug development, clinical trials, and various biomedical research fields…”
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Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam by Hassan Refat H. Ali, Ramadan Ali, Hany A. Batakoushy, Sayed M. Derayea

“…The structural information of the pharmaceuticals and insights on the modes of molecular interactions are very important aspects in drug development. In this work, two cephalosporins and antimicrobial combinations, cefepime-metronidazole and cefoperazone-sulbactam, were studied in the solid state using FTIR spectroscopy for the first time. …”
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Structure-Function of Falcipains: Malarial Cysteine Proteases by Kailash C. Pandey, Rajnikant Dixit

“…Overall, the complexes of falcipain-2 and falcipain-3 with small and macromolecular inhibitors provide structural insight to facilitate the design or modification of effective drug treatment against malaria. Drug development targeting falcipains should be aided by a strong foundation of biochemical and structural studies.…”
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Bhavana, an Ayurvedic Pharmaceutical Method and a Versatile Drug Delivery Platform to Prepare Potentiated Micro-Nano-Sized Drugs: Core Concept and Its Current Relevance by Rohit Sharma, Prashant Bedarkar, Deepak Timalsina, Anand Chaudhary, Pradeep Kumar Prajapati

“…A comprehensive review was performed on the core concepts of Bhavana, alongside its possible pharmacotherapeutic effects and relevance in drug development, by probing Ayurvedic claims in light of published pharmaceutical, analytical, and pharmacological reports. …”
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Simulation of clinical trials of oral treprostinil in pulmonary arterial hypertension using a virtual population by Andrew E. Stine, Jignesh Parmar, Amy K. Smith, Zachary Cummins, Narasimha Rao Pillalamarri, R. Joseph Bender

“…Abstract Challenges in drug development for rare diseases such as pulmonary arterial hypertension can be addressed through the use of mathematical modeling. …”
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2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses by Serban Georgeta

“…The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scientific papers report the antiparasitic potential of 2-amino-1,3,4-thiadiazoles. …”
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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis by Charles J. Malemud

“…Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. Indeed several experimental compounds alter the biological activity of these targets and have shown clinical efficacy in animal models of arthritis. …”
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Shikonin Induces Glioma Necroptosis, Stemness Decline, and Impedes (Immuno)Proteasome Activity by Xianyun Qin, Lu Zhang, Jilan Liu, Yan Lu, Fuyao Zhou, Feng Jin

“…The discussion extends to the potential of Shikonin as a promising therapeutic agent in the management of gliomas, offering a novel avenue for drug development in this challenging clinical context.…”
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Immunosenescence of Polymorphonuclear Neutrophils by Inga Wessels, Judith Jansen, Lothar Rink, Peter Uciechowski

“…This could form the basis for drug development in order to prevent or treat age-related diseases, and thus to unburden the public health systems.…”
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Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems by Yuxuan Liu, Yaohui Ou, Linlin Hou

“…Nucleic acids, as carriers of genetic information, have found wide applications in both medical and research fields, including gene editing, disease diagnostics, and drug development. Among various types of nucleic acids, RNA offers greater versatility compared to DNA due to its single-stranded structure, ability to directly encode proteins, and high modifiability for targeted therapeutic and regulatory applications. …”
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Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer by Qingqing Meng, Zheng Li

“…Molecular imaging has the potential to enhance our understanding of breast cancer biology and effects of drug action during both preclinical and clinical phases of drug development. This has led to the identification of many molecular imaging probes for key processes in breast cancer. …”
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Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis by Matthew D. Silva, Jason Ruan, Elizabeth Siebert, Anneli Savinainen, Bruce Jaffee, Lisa Schopf, Sudeep Chandra

“…The main advantage of such an algorithm is demonstrated in the preclinical drug study of rat CIA with methotrexate treatment, indicating the immediate utility of this approach in drug development studies.…”
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Peripheral Mechanisms of Symptom Generation in Irritable Bowel Syndrome by Stephen M Collins

“…The gut and the autonomic nervous system are principal areas of research in identifying mechanisms underlying symptom generation and in the identification of new targets for drug development. While motility changes occur in IBS, they are neither specific nor predictable, and this is one reason why drugs aimed at influencing motility patterns have enjoyed limited success to date. …”
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