Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity a... by Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu

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Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus by Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu

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Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions by Hyeon-Jeong Hwang, Youngsang Nam, Chanhee Jang, Eun La Kim, Eun Seo Jang, Yeo Jin Lee, Seoung Rak Lee

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Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of (<i>Z</i>)-5-Benzylidene-2-(naphthalen-1-ylamino)thiazol-4(5<i>H</i>)-one Analogs: In Vitro and In Vivo Insight... by Hee Jin Jung, Hye Jin Kim, Hyeon Seo Park, Hye Soo Park, Jeongin Ko, Dahye Yoon, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon

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Cost-effective whole-cell biosynthesis of ursodeoxycholic acid using engineered Escherichia coli with a multienzyme cascade by Xue Zhang, Xue Zhang, Jiagang Xin, Mengyu Liu, Mengyu Liu, Yue Zhang, Yue Zhang, Haoni Luan, Haoni Luan, Wei Feng, Wei Feng, Fei Wang, Fei Wang, Wei Xu, Wei Xu, Peng Song, Peng Song

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Ruthenium(II) Lipid‐Mimics Drive Lipid Phase Separation to Arouse Autophagy‐Ferroptosis Cascade for Photoimmunotherapy by Yue Zheng, Wen‐Jin Wang, Jing‐Xin Chen, Kun Peng, Xiao‐Xiao Chen, Qing‐Hua Shen, Bing‐Bing Liang, Zong‐Wan Mao, Cai‐Ping Tan

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Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

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Extraction and Bioactivity Analysis of Major Flavones Compounds from Scutellaria baicalensis Using In Vitro Assay and Online Screening HPLC-ABTS System by Kwang Jin Lee, Pil Mun Jung, You-Chang Oh, Na-Young Song, Taesoo Kim, Jin Yeul Ma

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Isolation and Bioactivity Analysis of Ethyl Acetate Extract from Acer tegmentosum Using In Vitro Assay and On-Line Screening HPLC-ABTS+ System by Kwang Jin Lee, Na-Young Song, You Chang Oh, Won-Kyung Cho, Jin Yeul Ma

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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007) by Raj Kalkeri, Junzhong Peng, Chunsheng Huang, Zhaohui Cai, Roger G. Ptak, Mark J. Suto

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Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production by Heather J Bax, Jitesh Chauhan, Alexandra J McCraw, Melanie Grandits, Chara Stavraka, Heike Lentfer, Tim Hillyer, Simon Carroll, Kim Vigor, Chris Selkirk, Mariangela Figini, Jack Cheeseman, Paulina A Urbanowicz, Richard A Gardner, Daniel I R Spencer, Nigel Westwood, Sarah Mellor, James Spicer, Debra H Josephs, Sophia N Karagiannis

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End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle by Xiaoyan Hu, Jingqi Zeng, Lijuan Ma, Xiaomeng Wang, Jing Du, Lu Yao, Zhisheng Wu

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Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance by Linna Xu, Xiaofen Mo, Hui Zhang, Fen Wan, Qixia Luo, Yonghong Xiao

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Optimization of a microarray for fission yeast by Dong-Uk Kim, Minho Lee, Sangjo Han, Miyoung Nam, Sol Lee, Jaewoong Lee, Jihye Woo, Dongsup Kim, Kwang-Lae Hoe

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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Pharmacokinetic studies indicate that WN2-R has high bioavailability (F = 20.29%), highlighting its considerable potential for drug development. Our study establishes WN2-R as a novel Nav1.7-selective inhibitor with a unique structural scaffold, offering a promising candidate for the next generation of analgesic drugs.…”
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Development and validation of a prognostic and drug sensitivity model for gastric cancer utilizing telomere-related genes by Xiaoxiao Li, Xiaoxuan Wang, Fuxiang Yu, Zhongguo Li, Daxin Chen, Yingxue Qi, Zhongyu Lu, Yaqin Liu, Dongsheng Chen, Yaoqiang Wu

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Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang by Hyejin Shin, Jihyun Kim, Musun Park, Heeseon Jo, Myunggyo Lee, Seongwon Cha, Haeseung Lee, Sooseong You

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Drug-target binding affinity prediction based on power graph and word2vec by Jing Hu, Shuo Hu, Minghao Xia, Kangxing Zheng, Xiaolong Zhang

“…Abstract Background Drug and protein targets affect the physiological functions and metabolic effects of the body through bonding reactions, and accurate prediction of drug-protein target interactions is crucial for drug development. In order to shorten the drug development cycle and reduce costs, machine learning methods are gradually playing an important role in the field of drug-target interactions. …”
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CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions by Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu

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