Evaluation of Ethnopharmacological and Antioxidant Potential of Zanthoxylum armatum DC. by Rabia Kanwal, Muhammad Arshad, Yamin Bibi, Saira Asif, Sunbal Khalil Chaudhari

“…Further in vitro and in vivo research should be performed, so this plant can be further utilized in drug development.…”
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Generative AI, IoT, and blockchain in healthcare: application, issues, and solutions by Tehseen Mazhar, Sunawar khan, Tariq Shahzad, Muhammad Amir khan, Mamoon M. Saeed, Joseph Bamidele Awotunde, Habib Hamam

“…Generative AI has additionally enhanced medical research and drug development, cutting the time and expense of introducing new medicines. …”
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Chemical profiling, in-vitro and in silico α-glucosidase inhibition, antioxidant and antibacterial activities of Hypotrachyna cirrhata (Fr.) Hale ex Sipman by Deepa Karki, Anuraj Phunyal, Tika Ram Lamichhane, Asmita Rayamajhi, Asmita Sapkota, Hari Nyaupane, Suraj Shrestha, Achyut Adhikari

“…Natural products are essential in drug development, with increasing interest in lichen-derived compounds for their therapeutic potential. …”
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RIOK1/2 Negatively Regulates the Antiviral Response by Targeting TBK1 in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) by Kejun Liu, Jiayang Huang, Yuting Gui, Qian Li, Lei Zhang, Shuting Xiong

“…Comprehending the fish’s immune mechanisms, particularly the regulation of the interferon (IFN) response, is of paramount importance for future drug development and disease-resistant molecular breeding. …”
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Antidiabetic Potential of Senna siamea: α-Glucosidase Inhibition, Postprandial Blood Glucose Reduction, Toxicity Evaluation, and Molecular Docking by Suthinee Sangkanu, Armad Heemman, Sathianpong Phoopha, Thanet Pitakbut, Wandee Udomuksorn, Sukanya Dej-adisai

“…This study offers encouraging information on the potential of natural compounds from S. siamea to act as α-glucosidase inhibitors for diabetes treatment through drug development or dietary supplement for hyperglycemia individuals.…”
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Thy1-YFP: an effective tool for single cell tracing from neuronal progenitors to mature functionally active neurons by Ante Plećaš, Katarina Kapuralin, Leonarda Grandverger, Dinko Mitrečić, Ivan Alić

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Evaluation of the EndoPAT as a Tool to Assess Endothelial Function by M. Moerland, A. J. Kales, L. Schrier, M. G. J. van Dongen, D. Bradnock, J. Burggraaf

“…This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.…”
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Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment by Alberto N. Peón, Yadira Ledesma-Soto, Jonadab E. Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I. Terrazas

“…A negative correlation between the geographical distribution of autoimmune diseases and helminth infections has been largely associated in the last few years with a possible role for such type of parasites in the regulation of inflammatory diseases, suggesting new pathways for drug development. However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS). …”
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Peroxiredoxin 5 Acts as a Negative Regulator of the Sodium-Chloride Cotransporter Involved in Alleviating Angiotensin II-Induced Hypertension by Hoon-In Choi, In Ae Jung, Soo Wan Kim

“…In conclusion, Prdx5 negatively regulates the WNK4-SPAK/OSR1-NCC signaling axis, indicating its potential as a candidate for antihypertensive drug development through NCC regulation.…”
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Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging by Liza Dahal, Thomas GW Graham, Gina M Dailey, Alec Heckert, Robert Tjian, Xavier Darzacq

“…SMT and PAPA thus provide a direct way to probe which components are functionally limiting within a complex TF interaction network providing new insights into mechanisms of gene regulation in vivo with implications for drug development targeting nuclear receptors.…”
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Analysis of Phenolic and Flavonoid Content, α-Amylase Inhibitory and Free Radical Scavenging Activities of Some Medicinal Plants by Lalit Kala Pandey, Khaga Raj Sharma

“…However, a detailed study can be performed in these plants to isolate the active chemical compounds and to evaluate in vivo pharmacological activities to know the active drug candidates for the future drug development process.…”
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Relationship between RSV-hospitalized children and meteorological factors: a time series analysis from 2017 to 2023 by Shuying Wang, Yifan Wang, Yingxue Zou, Cheng-liang Yin

“…This research intends to inform RSV prevention strategies, optimize public health policies and medical resource allocation while also promoting vaccine and therapeutic drug development. Methods This study analyzed data from a cohort of 6222 children hospitalized with RSV-related infections. …”
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Bacteriophage LDT325 enhances Pseudomonas syringae tolerance by improving antioxidant defense in tea plant [Camellia sinensis (L.) O. Kuntze] by Li Liu, Anqi Huang, Hua Zhang, Yubao Li, Lei Wang, Lei Wang

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Structural bioinformatics for rational drug design by Soroush Mozaffari, Agnethe Moen, Che Yee Ng, Gerry A.F. Nicolaes, Kanin Wichapong

“…This review explores the state of the art in computational drug discovery, examining the latest methods and technologies, their transformative impact on the drug development pipeline, and the future directions needed to overcome remaining limitations. …”
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Chemical Constituents of the Bark of Zanthoxylum gilletii (Rutaceae) and Their In Vitro Antiplasmodial and Molecular Docking Studies by Liliane Clotilde Dzouemo, Gervais Mouthé Happi, Sikiru Akinyeye Ahmed, Willifred Dongmo Tekapi Tsopgni, Michael Nde Akuma, Shina Salau, Emmanuel Ngeufa Happi, Jean Duplex Wansi

“…The present study provides further information to enrich the chemistry of Z. gilletii and its qualification as an important source for good candidates in new antiplasmodial drug development.…”
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Corrigendum: First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP: TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

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Examination of common culture medium for human hepatocytes and engineered heart tissue: Towards an evaluation of cardiotoxicity associated with hepatic drug metabolism in vitro. by Shinichiro Horiuchi, Nanae Koda, Yui Ikeda, Yuto Tanaka, Yusuke Masuo, Yukio Kato, Daiju Yamazaki

“…Our findings may facilitate the evaluation of cardiotoxicity via hepatic metabolism, potentially reducing animal testing, lowering costs, and expediting drug development.…”
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Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists by Atefeh Saadabadi, Linda Wilkman, Marja Rantanen, Ari-Pekka Koivisto, Outi M. H. Salo-Ahen

“…To identify potential TRPV4 inhibitors for drug development, we screened a library of ion channel-modulating compounds using both structure- and ligand-based virtual screening approaches. …”
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Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 by Stephanie Ghio, Jean-Pierre Brincat, Yuksel Cetin, Frederick Lia

“… Spices and Mediterranean medicinal plants provide a rich resource for novel antiviral drug development. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic with devastating outcomes, and hence, there is a global need to search for small-molecule inhibitors that can act against this viral pathogen. …”
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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“…By unraveling new design rules for antibody drug properties that are dependent on ML-based TO assessment, we deliver a first-in-class ML-based target pharmacology assessment framework toward better understanding of the biology-specific PK and ADME processes of antibody drug candidate proteins and reduce the overall time for drug development.…”
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