The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease by Yang Xu, Ji Zhang, Lingsong Ma, Shoucai Zhao, Shizun Li, Tingting Huang, Zhaohu Chu

“…Multiple inhibitors of RIPK1 and MLKL have been developed to block the cascade of signal pathways for procedural necrosis and represent potential leads for drug development. In this review, we highlight recent progress in the study of roles for necroptosis in cerebral ischemic disease and discuss how these modifications delicately control necroptosis.…”
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Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications by Devan Buchanan, Shogo Mori, Ahmed Chadli, Siva S. Panda

“…These advancements can potentially address complex diseases and advance the broader field of biological drug development.…”
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The continually evolving landscape of novel therapies in oncogene-driven advanced non-small-cell lung cancer by Barbara Melosky, Rosalyn A. Juergens, Shantanu Banerji, Adrian Sacher, Paul Wheatley-Price, Stephanie Snow, Ming-Sound Tsao, Natasha B. Leighl, Ilidio Martins, Parneet Cheema, Geoffrey Liu, Quincy S. C. Chu

“…Advances in molecular diagnostics and drug development have facilitated the targeting of novel alterations such that the majority of NSCLC patients have driver mutations that are now clinically actionable. …”
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Development of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains by Gangadhar Dhulipala, Alanna Broszeit, Kun Lu, Nisha Palackal, Erica Pyles

“…Further, the developed method can be applied in different aspects of drug development, such as comparability, release or stability testing given its ability to provide identity, as well as qualitative and quantitative comparative analysis.…”
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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…However, challenges such as the complexity of drug development and metabolic interactions must be overcome. …”
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Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes by Jianying Han, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Miaomiao Liu

“…The study also identified bafilomycins as potent scaffolds for anti-TB drug development, showcasing rapid bactericidal activity at low MIC values. …”
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Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn by Emmanuel B. A. Adusei, Reimmel K. Adosraku, James Oppong-Kyekyeku, Cedric D. K. Amengor, Yakubu Jibira

“…Plumbagin has been proved through this study to be a suitable lead compound in antimicrobial resistance drug development.…”
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The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance by Kavitha EZHILARASU, Anand KASIRANJAN, Shanmuga PRIYA, Anand KAMARAJ

“…Objective: Tinospora cordifolia, often known as 'Guduchi,' has a variety of medicinal characteristics, including those that are anti-diabetic, antiinflammatory, anti-periodic, anti-arthritic, anti-oxidant, anti-allergic, and anti-stress. Drug development projects face significant obstacles because of the rapid rise in antimicrobial drug resistance in the world healthcare system and the introduction of multidrug-resistant (MDR) strains. …”
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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway by Crystal Ngofi Zumbi, Chun-Hsu Pan, Hui-Yu Huang, Chieh-Hsi Wu

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Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development by Muhammad Ahmad, Muhammad Ahmad, Maleha Tahir, Zibin Hong, Muhammad Anjum Zia, Hamza Rafeeq, Muhammad Shaheez Ahmad, Saif ur Rehman, Junming Sun

“…This review explores the therapeutic potential of plant and marine sources along with innovative extraction and isolation methods that support sustainable drug development. Future perspectives will highlight the role of responsible innovation, artificial intelligence, and machine learning in advancing drug discovery, underscoring the importance of continued research to meet global health needs.…”
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Biomaterial-assisted organoid technology for disease modeling and drug screening by Yunyuan Shao, Juncheng Wang, Anqi Jin, Shicui Jiang, Lanjie Lei, Liangle Liu

“…Through continued research and innovation, we aim to make remarkable strides in disease treatment and drug development, ultimately enhancing patient quality of life.…”
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Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review by Maya G. Pillai, Helen Antony

“…Overcoming these limitations requires a concerted effort to address the complexities of NP drug development. Nevertheless, ongoing research efforts and interdisciplinary collaboration hold promise for advancing NP-based therapeutics, paving the way for the development of innovative treatments for various diseases. …”
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Comprehensive Analysis of Breast Cancer Cell Lines: Genome-wide Insights from ChIP-seq Analysis by Tanishq Sahu, Ruchi Yadav

“…Further, wet laboratory studies are required to verify the function of the predicted motifs and their importance in drug development or research in breast cancer.…”
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Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice by Wiwied Ekasari, Anisah Mahardiani, Nindya T. Putri, Tutik S. Wahyuni, Heny Arwati

“…The results showed the EECS was not toxic in mice and repaired the liver and kidney functions of P. berghei ANKA-infected mice, indicating a good candidate for antimalarial drug development.…”
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Accelerating antimicrobial peptide design: Leveraging deep learning for rapid discovery. by Ahmad M Al-Omari, Yazan H Akkam, Ala'a Zyout, Shayma'a Younis, Shefa M Tawalbeh, Khaled Al-Sawalmeh, Amjed Al Fahoum, Jonathan Arnold

“…This research contributes to the advancement of deep learning-based AMP drug discovery methodologies by generating potent peptides for drug development and application. This discovery has significant implications for the processing of biological data and the computation of pharmacology.…”
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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…The present study performed molecular docking and dynamics simulation to identify potential MAPK3 inhibitors from natural flavonoids, possibly leading to drug development in cancer therapy. Methods. A computational drug discovery approach was performed using the AutoDock tool to identify potential MAPK3 inhibitors from 46 plant-based flavonoids. …”
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Revolutionizing ovarian cancer therapy by drug repositioning for accelerated and cost-effective treatments by Edgar Yebran Villegas-Vazquez, Francisco Pável Marín-Carrasco, Octavio Daniel Reyes-Hernández, Andrea S. Báez-González, Lilia Patricia Bustamante-Montes, Teresita Padilla-Benavides, Laura Itzel Quintas-Granados, Gabriela Figueroa-González

“…In contrast to conventional drug development approaches, this innovative method has proven to be exceptionally effective. …”
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Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves by Amine Trabelsi, Mohamed Amine El Kaibi, Aïmen Abbassi, Amira Horchani, Leila Chekir-Ghedira, Kamel Ghedira

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Evaluation of peptide secondary structure and intracellular uptake by introducing disubstituted amino acids into the amphipathic helical peptide C18AA by Takuma Kato, Go Ofuka, Ryota Kobayashi, Akiko Asano, Mitsunobu Doi

“…Amphipathic helical peptides are common among antimicrobial and cell membrane-permeable peptides, and amino acid substitutions within existing peptides have been an effective means of new peptide drug development. In the present study, we evaluated the effect of introducing a disubstituted amino acid (dAA), which has a stabilizing effect on the helical structure of the amphiphilic peptide C18AA, on the secondary structure of C18AA and its intracellular uptake. …”
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Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Wanjoo Chun

“…Abstract Background The Plasmodium proteasome emerges as a promising target for anti-malarial drug development due to its potential activity against multiple life cycle stages. …”
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