Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes by Jianying Han, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Miaomiao Liu

“…The study also identified bafilomycins as potent scaffolds for anti-TB drug development, showcasing rapid bactericidal activity at low MIC values. …”
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Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn by Emmanuel B. A. Adusei, Reimmel K. Adosraku, James Oppong-Kyekyeku, Cedric D. K. Amengor, Yakubu Jibira

“…Plumbagin has been proved through this study to be a suitable lead compound in antimicrobial resistance drug development.…”
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The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance by Kavitha EZHILARASU, Anand KASIRANJAN, Shanmuga PRIYA, Anand KAMARAJ

“…Objective: Tinospora cordifolia, often known as 'Guduchi,' has a variety of medicinal characteristics, including those that are anti-diabetic, antiinflammatory, anti-periodic, anti-arthritic, anti-oxidant, anti-allergic, and anti-stress. Drug development projects face significant obstacles because of the rapid rise in antimicrobial drug resistance in the world healthcare system and the introduction of multidrug-resistant (MDR) strains. …”
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Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review by Maya G. Pillai, Helen Antony

“…Overcoming these limitations requires a concerted effort to address the complexities of NP drug development. Nevertheless, ongoing research efforts and interdisciplinary collaboration hold promise for advancing NP-based therapeutics, paving the way for the development of innovative treatments for various diseases. …”
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Toxicological Evaluation and Protective Effects of Ethanolic Leaf Extract of Cassia spectabilis DC on Liver and Kidney Function of Plasmodium berghei-Infected Mice by Wiwied Ekasari, Anisah Mahardiani, Nindya T. Putri, Tutik S. Wahyuni, Heny Arwati

“…The results showed the EECS was not toxic in mice and repaired the liver and kidney functions of P. berghei ANKA-infected mice, indicating a good candidate for antimalarial drug development.…”
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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…The present study performed molecular docking and dynamics simulation to identify potential MAPK3 inhibitors from natural flavonoids, possibly leading to drug development in cancer therapy. Methods. A computational drug discovery approach was performed using the AutoDock tool to identify potential MAPK3 inhibitors from 46 plant-based flavonoids. …”
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Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves by Amine Trabelsi, Mohamed Amine El Kaibi, Aïmen Abbassi, Amira Horchani, Leila Chekir-Ghedira, Kamel Ghedira

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Evaluation of peptide secondary structure and intracellular uptake by introducing disubstituted amino acids into the amphipathic helical peptide C18AA by Takuma Kato, Go Ofuka, Ryota Kobayashi, Akiko Asano, Mitsunobu Doi

“…Amphipathic helical peptides are common among antimicrobial and cell membrane-permeable peptides, and amino acid substitutions within existing peptides have been an effective means of new peptide drug development. In the present study, we evaluated the effect of introducing a disubstituted amino acid (dAA), which has a stabilizing effect on the helical structure of the amphiphilic peptide C18AA, on the secondary structure of C18AA and its intracellular uptake. …”
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Structural comparison of human and Plasmodium proteasome β5 subunits: informing selective inhibitor design for anti-malaria agents by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Wanjoo Chun

“…Abstract Background The Plasmodium proteasome emerges as a promising target for anti-malarial drug development due to its potential activity against multiple life cycle stages. …”
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Evaluation of Ethnopharmacological and Antioxidant Potential of Zanthoxylum armatum DC. by Rabia Kanwal, Muhammad Arshad, Yamin Bibi, Saira Asif, Sunbal Khalil Chaudhari

“…Further in vitro and in vivo research should be performed, so this plant can be further utilized in drug development.…”
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Generative AI, IoT, and blockchain in healthcare: application, issues, and solutions by Tehseen Mazhar, Sunawar khan, Tariq Shahzad, Muhammad Amir khan, Mamoon M. Saeed, Joseph Bamidele Awotunde, Habib Hamam

“…Generative AI has additionally enhanced medical research and drug development, cutting the time and expense of introducing new medicines. …”
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Chemical profiling, in-vitro and in silico α-glucosidase inhibition, antioxidant and antibacterial activities of Hypotrachyna cirrhata (Fr.) Hale ex Sipman by Deepa Karki, Anuraj Phunyal, Tika Ram Lamichhane, Asmita Rayamajhi, Asmita Sapkota, Hari Nyaupane, Suraj Shrestha, Achyut Adhikari

“…Natural products are essential in drug development, with increasing interest in lichen-derived compounds for their therapeutic potential. …”
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RIOK1/2 Negatively Regulates the Antiviral Response by Targeting TBK1 in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) by Kejun Liu, Jiayang Huang, Yuting Gui, Qian Li, Lei Zhang, Shuting Xiong

“…Comprehending the fish’s immune mechanisms, particularly the regulation of the interferon (IFN) response, is of paramount importance for future drug development and disease-resistant molecular breeding. …”
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Antidiabetic Potential of Senna siamea: α-Glucosidase Inhibition, Postprandial Blood Glucose Reduction, Toxicity Evaluation, and Molecular Docking by Suthinee Sangkanu, Armad Heemman, Sathianpong Phoopha, Thanet Pitakbut, Wandee Udomuksorn, Sukanya Dej-adisai

“…This study offers encouraging information on the potential of natural compounds from S. siamea to act as α-glucosidase inhibitors for diabetes treatment through drug development or dietary supplement for hyperglycemia individuals.…”
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Thy1-YFP: an effective tool for single cell tracing from neuronal progenitors to mature functionally active neurons by Ante Plećaš, Katarina Kapuralin, Leonarda Grandverger, Dinko Mitrečić, Ivan Alić

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Evaluation of the EndoPAT as a Tool to Assess Endothelial Function by M. Moerland, A. J. Kales, L. Schrier, M. G. J. van Dongen, D. Bradnock, J. Burggraaf

“…This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.…”
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Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment by Alberto N. Peón, Yadira Ledesma-Soto, Jonadab E. Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I. Terrazas

“…A negative correlation between the geographical distribution of autoimmune diseases and helminth infections has been largely associated in the last few years with a possible role for such type of parasites in the regulation of inflammatory diseases, suggesting new pathways for drug development. However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS). …”
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Peroxiredoxin 5 Acts as a Negative Regulator of the Sodium-Chloride Cotransporter Involved in Alleviating Angiotensin II-Induced Hypertension by Hoon-In Choi, In Ae Jung, Soo Wan Kim

“…In conclusion, Prdx5 negatively regulates the WNK4-SPAK/OSR1-NCC signaling axis, indicating its potential as a candidate for antihypertensive drug development through NCC regulation.…”
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Analysis of Phenolic and Flavonoid Content, α-Amylase Inhibitory and Free Radical Scavenging Activities of Some Medicinal Plants by Lalit Kala Pandey, Khaga Raj Sharma

“…However, a detailed study can be performed in these plants to isolate the active chemical compounds and to evaluate in vivo pharmacological activities to know the active drug candidates for the future drug development process.…”
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Relationship between RSV-hospitalized children and meteorological factors: a time series analysis from 2017 to 2023 by Shuying Wang, Yifan Wang, Yingxue Zou, Cheng-liang Yin

“…This research intends to inform RSV prevention strategies, optimize public health policies and medical resource allocation while also promoting vaccine and therapeutic drug development. Methods This study analyzed data from a cohort of 6222 children hospitalized with RSV-related infections. …”
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