Drug-Gene Interaction Prediction Method through Cross Granularity Subgraph Contrastive Learning and Attention Mechanism Fusion by HU Dongdong, PENG Yang, TAN Shuqiu, ZHU Xiaofei

“…[Purposes] Clarifying the interconnections between drugs and genes is an important topic in drug development. At present, the graph neural network method based on the random walk algorithm has achieved great results in identifying drug-gene interaction relationships. …”
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Exploration of Potent Human α-Glucosidase Inhibitors Using In Silico Approaches: Molecular Docking, DFT, Molecular Dynamics Simulations, and MMPBSA by Jyoti Bashyal, Bimal Kumar Raut, Siddha Raj Upadhyaya, Kabita Sharma, Niranjan Parajuli

“…These findings highlight their promise for future drug development targeting α-glucosidase inhibition in diabetes management; however, more research needs to be conducted.…”
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In Vitro and In Silico Analysis of Bergenia ciliata and Mimosa pudica for Inhibition of α-Amylase by Mahesh Bohara, Sajani Ghaju, Kabita Sharma, Surya Kant Kalauni, Karan Khadayat

“…Various medicinal plants with diverse chemical constituents have been extensively studied for drug development. Bergenia ciliata and Mimosa pudica have been traditionally used for the treatment of diabetes and consist of valuable phytochemicals. …”
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Adipokines as Drug Targets in Diabetes and Underlying Disturbances by Vinícius Andrade-Oliveira, Niels O.S. Câmara, Pedro M. Moraes-Vieira

“…We also survey current attempts to exploit adipokines for clinical applications, which hold potential as novel approaches to drug development in several immune-mediated diseases.…”
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Comprehensive evaluation of pure and hybrid collaborative filtering in drug repurposing by Clémence Réda, Jill-Jênn Vie, Olaf Wolkenhauer

“…Abstract Drug development is known to be a costly and time-consuming process, which is prone to high failure rates. …”
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MORF: Multi-view oblique random forest for hepatotoxicity prediction by Binsheng Sui, Qingzhuo He, Bowei Yan, Kunhong Liu, Yong Xu, Song He, Xiaochen Bo

“…Summary: Hepatotoxicity prediction is significant in drug development, so the experts expect to get effective and reliable references. …”
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Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids by Leah Liu Wang, Javier Seravalli, Brett Eaton, Yi Liu, Michael R. Holbrook, Wen-Jian Lan, Shi-Hua Xiang

“…Since marine indole alkaloids comprise a large diverse group of secondary metabolites, their biological properties would be helpful for pharmaceutical drug development to treat various filovirus infections.…”
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Organoids and spheroids: advanced in vitro models for liver cancer research by Mirella Pastore, Alessia Giachi, Elena Spínola-Lasso, Fabio Marra, Chiara Raggi

“…Spheroids and organoids have emerged as powerful tools due to their ability to replicate tumor microenvironment and facilitate preclinical drug development. Spheroids are simpler 3D culture models that partially recreate tumor structure and cell interactions. …”
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AVP-GPT2: A Transformer-Powered Platform for De Novo Generation, Screening, and Explanation of Antiviral Peptides by Huajian Zhao, Gengshen Song

“…Future research will explore its application to other viral targets and its integration into existing drug development pipelines.…”
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Synthesis and crystal structure of (S,E)-4-hydroxy-3-(2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)ethylidene)dihydrofura... by Li Shi-Qing, Zhou Jian, Dong Zhang-Chao, Pan Bo Wen, Shi Yang, Zhou Ying

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Detection of Garlic Powder Adulteration Using FTIR Spectroscopy and Chemometrics: A Case Study in an Indonesia Marketplace by Avika Rizky Elvira, Anggita Rosiana Putri, Luthfi Ahmad Muchlashi

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Optimized digital workflow for pathologist-grade evaluation in bleomycin-induced pulmonary fibrosis mouse model by Toshiki Goto, Akira Sano, Shinichi Onishi, Natsuko Hada, Rui Kimata, Saori Matsuo, Sohei Oyama, Atsuhiko Kato, Hideaki Mizuno, Masaki Yamazaki

“…This deep learning-based fibrosis grade assessment has the potential to streamline drug development for pulmonary fibrosis by offering higher granularity and reproducibility in evaluating BLM model.…”
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SARS-CoV-2 drug resistance and therapeutic approaches by Sania Batool, Santosh Chokkakula, Ju Hwan Jeong, Yun Hee Baek, Min-Suk Song

“…By examining the complex interactions between the virus and its host, the review advocates for a multifaceted approach, including combination therapies, targeted drug development, and continuous surveillance of viral mutations. …”
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A python approach for prediction of physicochemical properties of anti-arrhythmia drugs using topological descriptors by Huiling Qin, Mudassar Rehman, Muhammad Farhan Hanif, Muhammad Yousaf Bhatti, Muhammad Kamran Siddiqui, Mohamed Abubakar Fiidow

“…Anti-arrhythmic drug development is challenging due to the complex relationship between chemical structure and drug efficacy. …”
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Beyond immortality: Epstein–Barr virus and the intricate dance of programmed cell death in cancer development by Arezoo Esmaeili, Prankur Awasthi, Samira Tabaee

“…A deeper understanding of the molecular underpinnings of EBV's influence on cell death not only enriches the field of viral oncology but also pinpoints targets for drug development. Furthermore, the insights gleaned from this review could catalyze the design of vaccines aimed at preventing EBV infection or curtailing its oncogenic impact. …”
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Assessing traditional Chinese medicine from a molecular perspective by Minhui Su, Wenxi Wang, Xudong Sun, Lihong Li, Weihong Tan

“…Nucleic acids, a class of star functional molecules, are notable for their versatile applications in molecular diagnostics, gene therapy, and drug development. Therefore, in this study, we review the extensive use of nucleic acid aptamers in medicinal practice. …”
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In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase by Rishab Marahatha, Asmita Shrestha, Kabita Sharma, Bishnu P. Regmi, Khaga Raj Sharma, Pramod Poudel, Ram Chandra Basnyat, Niranjan Parajuli

“…While there have been some vaccines and drugs, the rapid emergence of variants due to mutations has threatened public health. As the de novo drug development process is expensive and time-consuming, repurposing existing antiviral drugs against SARS-CoV-2 is an alternative and promising approach to mitigate the current situation. …”
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Ethnopharmacology of Psychotria: Potential Use of P. malayana Jack Leaves as Antidiabetic Agent by Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Siti Zaiton Mat Soád, Qamar Uddin Ahmed, Zalikha Ibrahim

“…The review discusses the pharmacologically active compounds unique to these species, which are of considerable interest for drug development in diabetes treatment. A summary of these studies and their implications is presented. …”
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Decremental response in patients with amyotrophic lateral sclerosis during repetitive nerve stimulation and its relationships with impaired homeostasis by Jinghong Zhang, Yang Li, Qiang Shi

“…Independent factors contributing to decremental response need to be considered in drug development and clinical trials targeting NMJ in patients with ALS.…”
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A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation by Jyotirmoy Sarker, Pritha Das, Sabarni Sarker, Apurba Kumar Roy, A. Z. M. Ruhul Momen

“…These findings provide valid reasons for the assumption that inhibiting TMPRSS2 can have a beneficial effect in reducing the cellular entry of the virus, ultimately affecting the infection rate and case severity. Several drug development studies are going on to develop potential inhibitors of the protease, using both conventional and computational approaches. …”
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