Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies by Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin

Subjects: Get full text

Patterns of cannabidiol use among marijuana users in the United States by Ji-Yeun Park

Subjects: Get full text

Toward <i>Mycobacterium tuberculosis</i> Virulence Inhibition: Beyond Cell Wall by Maria S. Kotliarova, Mikhail S. Shumkov, Anna V. Goncharenko

Subjects: Get full text

Potentiometric and Blood Plasma Simulation Studies of Nickel(II) Complexes of Poly(amino)amido Pentadentate Ligands: Computer Aided Metal-Based Drug Design by Sebusi Odisitse, Graham E. Jackson

Get full text

Synthesis of Anti-Inflammatory Drugs’ Chalcone Derivatives and a Study of Their Conformational Properties Through a Combination of Nuclear Magnetic Resonance Spectroscopy and Molecular Modeling by Nikitas Georgiou, Andromachi Tzani, Kyriaki Vavougyiou, Christos Papadopoulos, Nikolaos Eleftheriadis, Primož Šket, Demeter Tzeli, Tuomas Niemi-Aro, Anastasia Detsi, Thomas Mavromoustakos

“…Conclusions: The in silico methods suggest that chalcones could be promising lead compounds for drug designs targeting the LOX enzyme.…”
Get full text

mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin by Kewei Zheng, Yi Gao, Jing Xu, Mingyi Kang, Ranran Chai, Guanqin Jin, Yu Kang

“…When combined with cisplatin, everolimus notably enhances the therapeutic efficacy without increasing the toxicity typically associated with platinum-based drugs. RNA-seq analysis uncovered alterations in the expression of apoptosis-related genes, suggesting that the underlying mechanism involves autophagy regulation. …”
Get full text

Fluorescence Spectrometric Determination of Drugs Containing 𝜶-Methylene Sulfone/Sulfonamide Functional Groups Using N1-Methylnicotinamide Chloride as a Fluorogenic Agent by Khaled M. Elokely, Mohamed A. Eldawy, Mohamed A. Elkersh, Tarek F. El-Moselhy

“…A simple spectrofluorometric method has been developed, adapted, and validated for the quantitative estimation of drugs containing 𝛼-methylene sulfone/sulfonamide functional groups using N1-methylnicotinamide chloride (NMNCl) as fluorogenic agent. …”
Get full text

Comparative effectiveness of urine drug screening strategies alongside opioid agonist treatment in British Columbia, Canada: a population-based observational study protocol by Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Jeong Eun Min, Micah Piske, Julie Bruneau, U Siebert, P Todd Korthuis, Paxton Bach, B Carolina Guerra-Alejos, Megan Kurz, Laura M Dale, X Joan Hu, Kyle Kampman, Tom Loughin

“…Introduction Urine drug tests (UDTs) are commonly used for monitoring opioid agonist treatment (OAT) responses, supporting the clinical decision for take-home doses and monitoring potential diversion. …”
Get full text

Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products by Catherina Caballero-George, Thomas Sorkalla, Daniel Jakobs, Jessica Bolaños, Huzefa Raja, Carol Shearer, Eldredge Bermingham, Hanns Häberlein

Get full text

A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder by Didakamiwan Khonglah, Arghya Pal, Nitu Mallik, Debes Ray, Malay Ghosal, Rudraprasad Acharya

Subjects: Get full text

Systematic review: characteristics of myocarditis followed by fixed drug eruption and dry eye syndrome in patients who have been vaccinated with monkeypox in children and adults by R. Mohamad Javier, Stephanie Angela Prijanto, Vallexa Septina Yora, Desak Gede Yuliana Eka Pratiwi, Errini Sabilla Lilhawa Ditsi, Bella Adelia, Verika Christabela Tansuri, Hendry Wijaya, Georaldhy Yussufy Caecarma, Intan Trikumala Damayanti, Anisa Ramadhanti, Atika Rahmaputri, Chabib Fachry Albab, Afif Ferdian, Fatih Farabi, Fadila Risang Ayu, Ni Putu Ika Regina Maharani, Andika Prasetyo Arifin, Eko Setyo Herwanto, Saidah Rahmat A, Safira Dita Arviana, Syifa Nur Lathifah, Nanda Rizki Yulinar, Laksmitha Saktiono Safitri, Basyar Adnani, M. Rizki Fazrian Danu, Natasya Naomi, Dayu Dwi Deria, Aulia Syifa, Panca Andana, Adrian Prasetya, Fachira Rachel Agfata, Magistra Cylvia Margaretha, Subandono Bambang Indrasto, Sukirman, Rachmanto, Hayatun Nufus, Pertiwi Febriana Chandrawati, Aan Dwi Prasetyo, Lucky Sutanto, Moch Aleq Sander

Subjects: Get full text

The Economic Burden of Infective Endocarditis due to Injection Drug Use in Australia: A Single Centre Study—University Hospital Geelong, Barwon Health, Victoria by Ohide Otome, Alexander Wright, Vanika Gunjaca, Steve Bowe, Eugene Athan

“…Background. Injection drug use (IDU) is a well-recognized risk factor for infective endocarditis (IE). …”
Get full text

Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma: Clinical Application to Therapeutic Drug Monitoring by Naser F. Al-Tannak, Ahmed Hemdan, Maya S. Eissa

“…A rapid and selective UPLC-DAD method was developed and validated for simultaneous analysis of the novel two-drug combination Darvoni® for the treatment of HCV: Sofosbuvir (SF)/Daclatasvir (DC) in human plasma using Ledipasvir as internal standard (IS) where the extraction process was conducted using automated SPE. …”
Get full text

Assessment of the Logical Prescription of Albumin Drug According to Guideline and Patient Safety for Inpatients in Intensive Care Units of Iranian Hospital: A Cross-Sectional Study by Naghme Dashti, Hesamoddin Hosseinjani, Saeid Eslami, Seyed Mohammad Tabatabaei, Hasan Vakili Arki

Subjects: “…Drug utilization evaluation…”
Get full text

Assessing awareness and utilisation of pre-exposure prophylaxis for HIV prevention among women who inject drugs in Lagos, Nigeria: a cross-sectional study by Olanrewaju Onigbogi, Modupe Onigbogi, Osadebamwen N Eghaghe, Omobola Y Ojo, Oluwatoyin Funmilola Babalola

“…Introduction Women who inject drugs (WWID) in Nigeria are more likely to be living with HIV than their male counterparts and could benefit from pre-exposure prophylaxis (PrEP). …”
Get full text

Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system by Ying Zhao, Yuke Zhong, Liuqing Wu, Jiao Yan, Weitao Lu

Subjects: “…Fall-risk-increasing drugs…”
Get full text

Chromatographic and Spectral Analysis of Two Main Extractable Compounds Present in Aqueous Extracts of Laminated Aluminum Foil Used for Protecting LDPE-Filled Drug Vials by Samuel O. Akapo, Sajid Syed, Anicia Mamangun, Wayne Skinner

“…Laminated aluminum foils are increasingly being used to protect drug products packaged in semipermeable containers (e.g., low-density polyethylene (LDPE)) from degradation and/or evaporation. …”
Get full text

Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs by Kawaljit Kaur, Angie Perez Celis, Anahid Jewett

Subjects: Get full text

Non-Steroidal Anti-Inflammatory Drugs Are Inhibitors of the Intestinal Proton-Coupled Amino Acid Transporter (PAT1): Ibuprofen and Diclofenac Are Non-Translocated Inhibitors by Carsten Uhd Nielsen, Sebastian Jakobsen, Maria L. Pedersen

“…<b>Background/Objectives</b>: The proton-coupled amino acid transporter (PAT1) is an intestinal absorptive solute carrier responsible for the oral bioavailability of some GABA-mimetic drug substances such as vigabatrin and gaboxadol. …”
Get full text

Efficacy and safety of conventional synthetic, biologic, and targeted synthetic disease-modifying antirheumatic drugs in rheumatoid arthritis-interstitial lung disease: A narrative review by Richard Conway, Luke Corcoran, Elena Nikiphorou

Subjects: “…biologic disease-modifying antirheumatic drugs…”
Get full text