Evaluating the health risk of probiotic supplements from the perspective of antimicrobial resistance by Qiwen Tian, Hailv Ye, Xuan Zhou, Junyi Wang, Lifang Zhang, Wenxuan Sun, Chenxin Duan, Minyu Fan, Wei Zhou, Chuyun Bi, Qiong Ye, Aloysius Wong

“…Our study detected ARGs in probiotics of health supplements conferring resistance to tetracycline, macrolide, aminoglycoside, and glycopeptide drugs. Streptomycin-adapted probiotics also gained resistance to other antibiotics more effectively than non-adapted ones. …”
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Corticosteroid use beyond 1-year post heart transplantation is associated with worse outcomes: A contemporary analysis of the ISHLT registry by Abhishek Jaiswal, MD, William L. Baker, Pharm.D, Ashwin Pillai, MD, Michelle Kittleson, MD, PhD, Balaphanidhar Mogga, MD, Zeina Jedeon, MD, Caroline Chen, David A. Baran, MD

“…Introduction: Immunosuppressive drugs ensure graft survival in heart transplantation (HT). …”
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Сlinical case of funicular myelosis in combination with a concomitant genetic predisposition to folate cycle disorder by O.D. Shulga, E.A. Popko, A.S. Chabanova, O.G. Kotsiuba, Q. Hussain

“…Funicular myelosis is a neurological complication of vitamin B12 deficiency, which occurs as a result of reduced intake of vitamin B12 with food, malabsorption, in connection with taking some drugs (metformin, proton pump inhibitors, and nitrous oxide), with invasion by Diphyllobothrium latum. …”
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PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis by JinJing Pan, Ping Wang, Linghong Xiong, Wenqing Yang, Jie Li, Kai Yang, Bingyan Li

“…It could be employed to helps in maintaining and extending the biological activity of the drugs, thereby enhancing their therapeutic efficacy. …”
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The Effects of Statin Dose, Lipophilicity, and Combination of Statins plus Ezetimibe on Circulating Oxidized Low-Density Lipoprotein Levels: A Systematic Review and Meta-Analysis o... by Tannaz Jamialahmadi, Fatemeh Baratzadeh, Željko Reiner, Luis E. Simental-Mendía, Suowen Xu, Andrey V. Susekov, Raul D. Santos, Amirhossein Sahebkar

“…Elevated plasma low-density lipoprotein cholesterol (LDL-C) is the main risk factor for atherosclerotic cardiovascular disease (ASCVD). Statins are the drugs of choice for decreasing LDL-C and are used for the prevention and management of ASCVD. …”
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Medical therapy to treat obesity and optimize fertility in women of reproductive age: a narrative review by Janelle Duah, David B. Seifer

“…Orlistat is another FDA-approved medication for weight loss; however, it is currently used much less often than other anti-obesity drugs because of its relatively lower efficacy and significant side effects. …”
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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…Limited by laboratory culture, no vaccines or drugs have been developed against HuNoVs. Here, we screened nucleic acid aptamers against the widespread HuNoV GII.4 and emerging HuNoV GII.17.Methods: After ten rounds of sieving for HuNoV GII.4 and GII.17 virus-like particles (VLPs), eight ssDNA aptamers were generated and characterized for each genotype.Results: Four of the eight aptamers generated for GII.4 VLP had dissociation constants (Kd) less than 100 nM, and all aptamers for GII.17 VLP had Kd less than 10 nM. …”
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Effect of Sling Exercise Therapy combined with Inspiratory Muscle Strength Training for Stroke Patients with Hemiplegia by Wenlin SUN, Dianhuai MENG, Yangyang LIU, Xiaoyong SU, Yang LIU, Fangfang ZHANG, Tiantian ZHAO

“…The control group received conventional drugs combined with conventional rehabilitation training(including joint range of motion training, PNF techniques, standing balance training, walking training, and activity of daily living training, etc.), rehabilitation training for 40 minutes a time, twice a day, five days a week, continous training for six weeks. …”
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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

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Evolution of the microbiota of wound infections in military personnel during the full-scale russian invasion: a retrospective cohort study (2022–2024) by N.A. Beley, O.A. Loskutov, A.M. Strokan, O.B. Izmaylova

“…The disc diffusion method was used to determine the sensitivity of isolates to antimicrobial drugs. Results. The study included 478 servicemen (mean age of 36.60 ± 0.42 years, range 18–67, 99.6 % were males) who have had 1441 wound cultures, and 2483 isolates were identified. …”
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Dominant spoilage bacteria in crayfish alleviate ultrasonic stress through mechanosensitive channels but could not prevent the process of membrane destruction by Zechuan Dai, Lingyun Meng, Sai Wang, Jiao Li, Xiangzhao Mao

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Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients. by Abirami Kugadas, Pietro Artoni, Wanida Ruangsiriluk, Meng Zhao, Natalia Boukharov, Rizwana Islam, Dmitri Volfson, Katayoun Derakhchan

“…There is a significant need for a translational model that could be used for testing cardiac efficacy of new drugs. Two mouse models of FD have been developed. …”
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CDK14 regulates the development and repair of lung by Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen

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Meta Analysis of Clinical Efficacy of Traditional Chinese Medicine Compounds of Huoxue Yangyin in the Treatment of Vocal Cord Polyp after Surgery by GE Xiaoni, ZHU Ling, SONG Ruohui, TU Yanhong, ZHENG Rixin

“…The patients with vocal cord polyp after surgery in the clinical randomized controlled trials (RCTs) were included who were treated with promoting blood circluation and nourishing Yin drugs. The retrieval time for each database was from January 2000 to May 2021. …”
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The formation pathway of flavor compounds in steamed Antarctic krill (Euphausia superba) based on untargeted metabolomics by Tingting Yang, Yang Liu, Jing Bai, Yan Fan, Ye Chen, Ping Dong, Xia Yang, Hu Hou

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IOP-lowering effect and tolerability of prostaglandin analogues in primary open-angle glaucoma and ocular hypertension as risk factors for glaucoma progression by A.V. Belogurova, E.N. Eskina, Zh.G. Oganezova

“…Preservative-containing antiglaucoma drops induce secondary “dry eye” syndrome, conjunctival hyperemia, thereby reducing the patient’s adherence to treatment and, in some cases, provoking self-abolition of antiglaucoma drugs by patients.<br> The article reviews the data on IOP-lowering effect and tolerability of preservative-free tafluprost 0.0015% in patients with POAG and ocular hypertension who have switched from preservative-containing prostaglandin analogues. …”
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The fundus changes in pathological myopia by Markosyan G.A., Tarutta E.P, Tarasova N.A., Maksimova M.V.

“…Despite recent advances in the treatment of choroidal neovascularization by administering drugs that block vascular endothelial growth factor and achievement of vitreoretinal surgery in vitreomacular traction syndrome, most of the complications of pathological myopia, such as macular atrophy, chorioretinal atrophy, and optic neuropathy, remain incurable.…”
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CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…The R package “maftool” was used to explore somatic mutation information in pancreatic cancer, and the TIDE database and the R package “oncoPredic” were used to explore immunotherapeutic responses and sensitive drugs. Pancreatic cancer cell lines were constructed with the specific expression of CYFIP2 mRNA, and their invasive and metastatic abilities were analysed using scratch and transwell assays. …”
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Risk factors and consequences of traumatic brain injury in a Swiss male population cohort by Jean-Bernard Daeppen, Gerhard Gmel, Joseph Studer, Valentin Petre Matei, Alina Elena Rosca, Alexandru Neculai Pavel, Radu Mihai Paun

“…Risk factors were measured at baseline (2010–2012) and at follow-up 1 (FU1; 2012–2014), while the consequences and TBI were measured at follow-up 2 (FU2; 2016–2018).Setting Switzerland.Participants All participants at FU2 (Mage=25.43, SD=1.25) of the Cohort Study on Substance Use Risk Factors (N=4881 young Swiss men after listwise deletion).Measures The outcomes measured were TBI, SUD (ie, alcohol, nicotine, cannabis, other illicit drugs), depression and personality traits (ie, sensation seeking, anxiety-neuroticism, sociability, aggression-hostility) at FU2. …”
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Novel Thiosemicarbazone Derivatives from Furan-2-Carbaldehyde: Synthesis, Characterization, Crystal Structures, and Antibacterial, Antifungal, Antioxidant, and Antitumor Activities by Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Maik Icker, Harald Krautscheid, Lothar Beyer, Carmen Tamariz-Angeles, Percy Olivera-Gonzales

“…Compound 5 exhibited significant antibacterial activity against Staphylococcus aureus ATCC700699 (MIC = 1 μg/mL) compared to the nitrofurantoin and gentamicin reference drugs (MIC = 1–25 and 10->100 μg/mL, respectively). …”
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