Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…., to include antiviral or other anti-inflammatory drugs.<h4>Main outcomes and measures</h4>The primary outcome was intubation or death within 14 days of randomization. …”
Get full text

Ilaser Submucous Destruction in the Treatment of Hemorrhoids by S. A. Frolov, D. V. Vyshegorodtsev, A. M. Kuzminov, Yu. L. Trubacheva, V. Yu. Korolik, I. S. Bogormistrov, I. A. Mukhin, A. N. Ryndin, A. A. Anarbaeva

“…The analysis of the intensity of the pain syndrome, the consumption of nonsteroidal anti-inflammatory drugs and the assessment of the quality of life on the SF-36 scale was carried out. …”
Get full text

Impact of COVID-19 on rheumatic diseases in india: Determinants of mortality and adverse outcome: A retrospective, cross-sectional cohort study by Avinash Jain, Vineeta Shobha, S Chandrashekara, Padmanabha Shenoy, Sapan C Pandya, Prakash Chotalia, Sharath Kumar, Sourabh Malviya, Yogesh Preet Singh, Abhishek Patil, Vikas Gupta, Puja Srivastava, Vijaya Prasanna Parimi, Chanakya Kodishala, Ramya Janardana, Benzeeta Pinto, Sudhir Bhandari, Govind Rankawat, Praveen Pratap Jadhav, Damodaram Potugari, Vishnu Sharma, Alpana Parmar, Sunitha Kayidhi, Paul T Antony, Ashish Badika, Amit Sharma

“…The results indicate that patients with RD do not show increased mortality despite current use of disease-modifying anti-rheumatic drugs/immunosuppressants.…”
Get full text

Changes in hemodynamic parameters with different anaesthesia induction agents in elderly patients with coronary heart disease by A.R. Vitovskyi, O.A. Loskutov

“…After the administration of induction drugs, a significant difference was observed only in mean arterial pressure (MAP): group 1 — 72.71 ± 4.76 %, group 2 — 81.29 ± 5.4 % of the baseline, p = 0.0001. …”
Get full text

Preservative-free IOP-lowering medications: potential advantages by I.B. Alekseev, I.A. Koroleva

“…Pharmacotherapy for glaucoma implies long-term instillations of IOP-lowering drugs. However, more glaucoma medications per day are required with time. …”
Get full text

Allelopathic effects on vegetative propagation, physiological-biochemical characteristic of Alternanthera philoxeroides (Mart.) Griseb from Cinnamomum camphora (L.) Presl. by Xiaxia Wang, Haixia Wang, Yanlei Zhang, Yan Li, Qi Jia, Ziyi Wang, Juan Sun

Get full text

“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer by ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin

“…They deeply analyzed the molecular characteristics of TNBC, leading to the development of a “Fudan subtype” closely related to clinical outcomes: luminal androgen receptor subtype (LAR), which can be targeted with anti-HER2 and CDK4/6 inhibitors; the immunomodulatory subtype (IM), suitable for immunotherapy; basal-like immune-suppressed subtype (BLIS), which can be treated with platinum-based drugs or poly (ADP-ribose) polymerase (PARP) inhibitors; and mesenchymal-like subtype (MES), which can be treated with anti-cancer stem cell and anti-angiogenic therapies. …”
Get full text

Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya by Bibianne Waiganjo, Gervason Moriasi, Jared Onyancha, Nelson Elias, Francis Muregi

“…The currently prescribed antimalarial drugs have been associated with adverse side effects ranging from intolerance to toxicity. …”
Get full text

Efficacy and safety of sequential therapy for primary osteoporosis with bone formation promoters followed by bone resorption inhibitors: a meta-analysis by Yuxin Liu, Xin Liu, Yuefeng Wu, Tao Luo

“…Pooled analysis showed that the intervention group (bone formation promoters followed by bone resorption inhibitors) increased BMD at the spine (SMD:1.64; 95% CI: 0.97, 2.31; P < 0.00001; I2 = 99%), femoral neck (SMD: 0.57; 95% CI: 0.16, 0.99; P = 0.007; I2 = 96%), and total hip (SMD: 0.82; 95% CI: 0.16, 1.48; P = 0.02; I2 = 97%) compared with the comparator group (monotherapy or combination therapy using two drugs)for postmenopausal osteoporosis patient; however, there was no statistically significant difference observed in the increase of BMD at the 1/3 distal radius comparing the intervention group and comparator group (SMD: -0.25; 95% CI: -1.49, 0.99; P = 0.069; I2 = 92%). …”
Get full text

Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions by Aviva Levina, Debbie C. Crans, Peter A. Lay

“…IntroductionCatechol moieties are common in natural bioactive molecules, and their ability to bind metal ions is widely explored both naturally with siderophores and in the development of metal-based drugs. The reactivities and biology activities of a sterically hindered model catechol compound, 3,5-di-tert-butylcatechol (dtbH2) and its oxidation product 3,5-di-tert-butyl-o-quinone (dtbQ), were studied in cell culture medium to understand better the medicinal roles of this class of molecules.MethodsAnti-proliferative activities of dtbH2 and dtbQ in fresh and aged solutions of the molecules were studied in two common human cancer cell lines, T98G (glioblastoma) and A549 (lung carcinoma). …”
Get full text

Strengthening research preparedness for crises: lessons from Norwegian government agencies in using randomized trials and quasi-experimental methods to evaluate public policy inter... by Unni Gopinathan, Ingeborg Elgersma, Therese Dalsbø, Mona Bjørbæk, Atle Fretheim

“…A key takeaway from the coronavirus disease 2019 (COVID-19) pandemic was that although numerous randomized controlled trials (RCTs) focussed on drugs and vaccines, few policy experiments were conducted to evaluate effects of public policy interventions across various sectors on viral transmission and other consequences. …”
Get full text

Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens by Paras Famta, Saurabh Shah, Biswajit Dey, Kondasingh Charan Kumar, Deepkumar Bagasariya, Ganesh Vambhurkar, Giriraj Pandey, Anamika Sharma, Dadi A. Srinivasarao, Rahul Kumar, Santosh Kumar Guru, Rajeev Singh Raghuvanshi, Saurabh Srivastava

Get full text

Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review by Anisha Panesar, Palma Gharanei, Natasha Khovanova, Lawrence Young, Dimitris Grammatopoulos, Dimitris Grammatopoulos

“…Medications administered during the acute illness phase, such as corticosteroids and antiviral drugs, can also impact thyroid hormone actions. The involvement of the thyroid gland in long COVID, or postacute sequelae of SARS-CoV-2 infection, is an area not well defined, with potential implications for understanding and managing this condition. …”
Get full text

Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China by Liqing Wei, Jun Chen, Zhen Deng, Zefang Zhang, Zhengbin Zhang, Qionghong Duan

“…Whole genome sequencing (WGS) was used to identify resistance-conferring mutations, examine their associations with specific Mycobacterium tuberculosis lineages or sublineages, and assess clustering profiles.ResultsAmong the 149 analyzed strains, the most prevalent mutations associated with resistance to 11 anti-tuberculosis drugs were identified as follows: rpoB Ser450Leu (59.73%, rifampicin), katG Ser315Thr (62.42%, isoniazid), embB Met306Val (42.86%, ethambutol), rpsL Lys43Arg (68.13%, streptomycin), pncA Trp68Arg (10.53%, pyrazinamide), gyrA Asp94Gly (22.50%, fluoroquinolones), and rrs 1401A &gt; G (50.00–100.00%, second-line injectable aminoglycosides). …”
Get full text

Antibiotic knowledge and influencing factors among residents in China: a cross-sectional survey by Sixian DU, Yaqing LIU, Xiaoxu YIN, Haoran NIU, Feng JIANG, Liwen GONG

“…Among them, 84.07% (739 people) mistakenly identified antibiotics as anti-inflammatory drugs; the average score for antibiotic knowledge was 8.73 ± 3.212 points. …”
Get full text

Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects by Feng Cheng, Tao Shen, Fucheng Zhang, Chenghao Lei, Ye Zhu, GuoJun Luo, Dawei Xiao

“…It urgently needs good generic drugs to help ease patients’ burden and improve their quality of life.ObjectiveThe primary objective of this study was to evaluate the bioequivalence of fluticasone propionate nebuliser suspensions between test formulation (generic product) and reference formulation (original product, Flixotide Nebules®) with the pharmacokinetic parameters as the endpoint indicators and the secondary objective was to evaluate the safety of two inhalated fluticasone propionate nebuliser suspensions under the condition of fasting in healthy Chinese subjects.MethodsThe bioequivalence study was conducted with a single-center, randomized, open-label, single-dose, two sequences, two-period crossover design. 24 healthy subjects were randomly assigned into T-R and R-T sequence groups with 12 patients in each group. …”
Get full text

Enzymatic Activity and Horizontal Gene Transfer of Heavy Metals and Antibiotic Resistant Proteus vulgaris from Hospital Wastewater: An Insight by Manzar Alam, Nilofer Bano, Tarun Kumar Upadhyay, Reem Binsuwaidan, Nawaf Alshammari, Amit Baran Sharangi, Radhey Shyam Kaushal, Mohd Saeed

“…The P. vulgaris isolates displayed multidrug resistance patterns (2–12 drugs) in various antibiotic combinations. The MAR indexes were shown to be between (0.02–0.7). …”
Get full text

Application of N-Acetyl-Glucosaminil-N-Acetyl-Muramyl Dipeptide during Triple Component Anti-Helicobacter Pylori Therapy in the Period of Coronavirus Infection COVID-19 by M. R. Konorev, E. N. Tyshevich, R. A. Pavlyukov

“…H. pylori in the gastric mucosa was detected by a morphological method and a rapid urease test before treatment and 6-8 weeks after the end of treatment and the withdrawal of all drugs. Patients were divided into three groups according to treatment protocols: omeprazole 0.04 g/day, clarithromycin 1 g/day, amoxicillin 2 g/day (OСA; n = 103); omeprazole 0.04 g/day, clarithromycin 1 g/day, amoxicillin 2 g/day + GMDP 0.001 g/day (OCAL1; n = 61) or 0.01 g/day (OCAL10; n = 44) for 10 days. …”
Get full text

Development and validation of a UV/visible spectrophotometric method for simultaneous assay of paracetamol and ibuprofen by Timothée Mavanga Mabaya, Jocelyn Mankulu Kakumba, Mannix Mayangi Makola, Adelard Mbenza Puati, Didi Mana Kialengila, Jean Mavar Tayey Mbay, Jérémie Mbinze Kindenge

“…Purpose This research aimed to provide a simple, reliable, and economical method for quality control of drugs and healthcare products in the Congolese pharmaceutical market. …”
Get full text

Establishment and application of a rapid new detection method for antimicrobial susceptibility testing of Klebsiella pneumoniae based on MALDI-TOF MS by Yapei Zhang, Fanghua Fan, Xuan Wang, Jie Zhu, Shilei Dong

“…Guidelines recommend targeted therapy based on minimum inhibitory concentration results, which directly reflect the effectiveness of antibacterial drugs. The gold standard method of AST relies on visible bacterial growth, causing long turnaround times. …”
Get full text