Impact of COVID-19 restrictions on behavioural and psychological symptoms in home-dwelling people with dementia: a prospective cohort study (PAN.DEM) by Maarja Vislapuu, Mala Naik, Bettina S Husebø, Marie H Gedde, Ipsit V Vahia, Janne Mannseth, Line I Berge

“…Moreover, depressive symptoms increased as assessed by CSDD total score (5 (3–9) to 7 (4–12), p=0.01) and worsened for 56 (54%), which was inversely associated with psychotropic drugs on-demand (0.16, 0.03 to 0.75).Conclusions BPSD worsened during the first months of the COVID-19 restrictions, most pronounced for psychosis and depression. …”
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Effects of different doses of remimazolam on the quality of sedation and cardiac function in elderly patients: a double-blind randomised controlled study by Liu Minghong, Qizhu Feng, Huichun Chen, Ju Li, Jun Shi

“…The number of vasoactive drugs used in Group H was higher than that in Group L and Group M, with statistically significant differences (P < 0.05).ConclusionsGeneral anesthesia induction with remimazolam besylate at 0.3 mg/kg in elderly patients undergoing laparoscopic cholecystectomy showed good quality of sedation, could achieve rapid intubation, with minimal effect on cardiac function and generally favorable safety profile.…”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…In addition, key biomarkers were acquired by two machine learning algorithms, then immune infiltration analysis, Gene Set Enrichment Analysis (GSEA), and potential drugs screening were conducted. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and western blotting were utilized to detect the ITGB2 expression. …”
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Effect of perioperative esketamine use on emergency delirium in children undergoing tonsillectomy and adenoidectomy: a systematic review and meta-analysis of randomized controlled... by Junfeng Liu, Jinming Liu, Hong Sun, Xue Cheng, Chunhui Wang, Daoyun Lei, Chao Han

“…Two evaluators identified randomized controlled trials comparing perioperative use of esketamine with placebo or other drugs in children undergoing tonsillectomy and adenoidectomy. …”
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Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival by John I. Robinson, Laura R. Marks, Andrew L. Hinton, Jane A. O'Halloran, Charles W. Goss, Peter J. Mucha, Jeffrey P. Henderson

“…Infection prognosis takes on particular importance when allocating scarce antiviral antibodies and drugs, which are most effective when administered before the onset of severe disease. …”
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The importance of the Autostrain RV technique in the treatment of right ventricular myocardial alterations in patients with breast cancer receiving chemotherapy by Yan Liang, Ping Du, Yabo Song, Xinshi Li, Yingying Han, Hongfang Dongye, Hongqiang Liu, Jinqiu Li

“…The patients included those with breast cancer who underwent surgery and were primarily administered anthracycline-based chemotherapeutic drugs. (1) Compared with the pre-chemotherapy period, the absolute values of the right ventricular global longitudinal strain (RV4CSL) and right ventricular free-wall longitudinal strain (RVFWSL) decreased after the fourth chemotherapy cycle, and no significant differences were observed in tricuspidannular plane systolic excursion (TAPSE), right ventricular Tei index, and right ventricular fractional area change (FAC); (2) Compared with the pre-chemotherapy period, the absolute values of RV4CSL and RVFWSL decreased after the eighth chemotherapy cycle. …”
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Benefits, challenges, and best practices of collaborative partnerships among health supply chain stakeholders in Rwanda: a cross-sectional study by Anitha Tuyishime, Innocent Hahirwa, Kato Jonas Njunwa, John Nyiligira

“…These were the Ministry of Health, Rwanda Biomedical Center, Rwanda Food and Drugs Authority, Rwanda Medical Supply Ltd, other Central Medical Stores namely Bureau des Formations Médicales Agréées du Rwanda (BUFMAR) and Medical and Allied Service Solutions (MEDIASOL); private wholesale pharmacies, non-government organizations, and Health Facilities (hospitals). …”
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The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions by Xuegang Li, Haijian Jiang, Xu Wang, Shuping Zhong

“…Results There were no significant differences between two groups in terms of gender, age, body mass index (BMI), duration, smoking, HLA-B27 positivity rate, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), BASDAI, ASDAS-ESR, ASDAS-CRP, biological disease-modifying anti-rheumatic drugs (bDMARDs) rate. No significant differences were observed in terms of OPG, PINP, CTX-I or OC between two groups. …”
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Knowledge, Attitude, and Associated Factors towards Nonpharmacological Pain Management among Nurses Working at Amhara Region Comprehensive Specialized Hospitals, Ethiopia by Esayas Alemshet Tekletsadik, Abebaw Alemayehu Desta, Belayneh Shetie Workneh

“…Nonpharmacological pain management refers to providing pain management intervention that does not involve the use of drugs. Effective management of a patient’s pain is a vital nursing activity, and it needs a nurse’s adequate pain-related knowledge and a favorable attitude. …”
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IgG4 as a Biomarker in Graves’ Orbitopathy by Michał Olejarz, Ewelina Szczepanek-Parulska, Daniela Dadej, Nadia Sawicka-Gutaj, Remigiusz Domin, Marek Ruchała

“…Characteristic features of GD with elevated IgG4 levels include lower echogenicity of the thyroid gland on ultrasound examination, peripheral blood eosinophilia, higher prevalence of orbitopathy, and better response to antithyroid drugs with a tendency to develop hypothyroidism when compared to patients with GD and normal levels of IgG4. …”
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Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota by Qing Liu, Teng Ma, Cuijiao Feng, Yalin Li, Hao Jin, Xuan Shi, Lai-Yu Kwok, Yan Shi, Tingtao Chen, Heping Zhang

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Changes induced in mouse lipid metabolism by simultaneous impact of antisense oligonucleotide derivatives to <i>apoB</i>, <i>PCSK9</i>, and <i>apoCIII</i> mRNAs by S. I. Oshevski, Y. I. Ragino, E. V. Kashtanova, Y. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda

“…Development of new drugs able to decrease the level of “bad” cholesterol, in particular, based on antisense oligonucleotide derivatives (ASOs), remains relevant for the patients with familial hypercholesterolemia and/or intolerant to statins. …”
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Efficacy and safety of nivolumab plus ipilimumab in gastrointestinal cancers: a systematic review and meta-analysis by Bowen Dai, Jiaping Jiang, Xiaoyu Yu, Haihua Zhan, Zhengchuan Hu

“…The control group was chemotherapy or nivolumab monotherapy or nivolumab in combination with other drugs. We extracted data from 10 randomized controlled trials and utilized a random effects model to assess the objective response rate (ORR), median progression-free survival (mPFS), median overall survival (mOS), median duration of response (mDOR), and treatment-related adverse events (TRAEs). …”
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Efficacy of Esophageal Protector in Treating Gastroesophageal Reflux Disease with Extraesophageal Symptoms: a Multicenter, Open-Label, Observational Study by Yu. A. Kucheryavy, D. N. Andreyev, E. Yu. Eryomina, A. A. Gilmanov, O. V. Nazarova, Ye. A. Sidneva, Yu. G. Topalova

“…In addition, the results showed that the proportion of patients taking antacid-containing drugs at visit 1 significantly decreased from 58.2 % (95 % CI: 54.0–62.4) to 15.2 % (95 % CI: 12.1–18.3) by visit 2. …”
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Crocin Monotherapy in Non-Central Diabetic Macular Edema by Mojtaba Mojtahedzadeh, Masoud Reza Manaviat, Seyed Reza Mirjalili, Adeleh Sahebnasagh, Mohammad Khan Ardani, Farahnaz Hoseinzadeh, Fatemeh Saghafi

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Resource Management and Health Service Delivery in Rukungiri Municipality: A Case Study of Rwamahwa Health Center IV. by Ndyamuhak,i Faith

“…The study findings on the influence of material resource management on health service delivery at Rwamahwa Health Center IV Rukungiri Municipality were; that the health center has an adequate stock of drugs and medicines which ease service delivery, the health center has all the basic equipment and facilities in place to ensure better service delivery, the health equipments are well maintained to use provision of services and the health centre has a budget for maintenance to ensure that service delivery is to the desired standards. …”
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Distribution and Antifungal Susceptibility Profile of Oropharyngeal Candida Species Isolated from People Living with HIV in the Era of Universal Test and Treat Policy in Uganda. by Musinguzi, Benson, Turyamuhika, Laban, Mwesigwa, Alex, Nalumaga, Pauline Petra, Kabajulizi, Immaculate, Njovu, Israel Kiiza, Mwebesa, Edson, Luggya, Tonny, Ocheng, Francis, Kateete, David Patrick, Itabangi, Herbert, Mboowa, Gerald, Obondo, James Sande, Achan, Beatrice

“…Additionally, the antifungal susceptibility profile of Candida isolates to six antifungal drugs was determined using the VITEK® (Marcy-l’Étoile, France) compact system. …”
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Decentralization and Primary Health Care Service delivery in Local Governments in Uganda: A Case Study of Kabale Municipality by Julius, Kisembo

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Decentralization and Public Health Services Delivery in Kabale Municipality, Kabale District, Uganda by Boaz, Mubangizi

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Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model by Zhuo-ma Dawa, Zhuo-ma Dawa, Ting Zhai, Ting Zhai, Chuan-chuan Liu, Chuan-chuan Liu, Hai-ning Fan, Hai-ning Fan

“…Therefore, there is a need to find new anti-Echinococcosis drugs. Pseudolaric acid B (PAB) has been described to have strong antiparasitic effects. …”
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