The Duty of Adverse Drug Reaction Alerting from the Perspective of Laws, Current Practices, and Guidelines Related to a Comparative Rights Approach by milad mashayekh, vali eslami

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Prophylactic Therapy of Silymarin (Milk Thistle) on Antituberculosis Drug-Induced Liver Injury: A Meta-Analysis of Randomized Controlled Trials by Lina Tao, Xiaoyu Qu, Yue Zhang, Yanqing Song, Si-xi Zhang

“…Prophylactic therapy with silymarin to prevent the development of antituberculosis drug-induced liver injury (anti-TB DILI) has been under debate. …”
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Therapeutic potential of boric acid as a local drug delivery agent in periodontitis: a comprehensive systematic review and meta-analysis by Reham Abdel-Fatah, Ghada A. Elhusseiny, Wafaa Saleh

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Aqueous spice extracts as alternative antimycotics to control highly drug resistant extensive biofilm forming clinical isolates of Candida albicans. by Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Priya Ashrit, Uddagiri Venkanna Babu, Lakavalli Mohan Sharath Kumar, Vasulingam Sampath, Kalidas Shetty, Amruta Purushottam Joglekar, Rashmi Awaknavar

“…The results of this study indicated that the alternate approach in controlling high biofilm-forming, multi-drug resistant clinical isolates of C. albicans M-207 and S-470 using whole aqueous extracts of garlic, clove, and Indian gooseberry is a safe, potential, and cost-effective one that can benefit the health care needs with additional effective therapeutics to treat biofilm infections.…”
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The Cost-effectiveness of Celecoxib versus Non-steroidal Anti-inflammatory Drugs plus Proton-pump Inhibitors for Treating Osteoarthritis in Algeria by Nadir Hammoumraoui, Sid Ahmed Kherraf, Joaquin Mould-Quevedo, Tarek A. Ismail

“…**Background:** Cyclooxygenase-2 inhibitors such as celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA), have fewer gastrointestinal side effects, but are more expensive. …”
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Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India by S. Sinha, H. Ahmad, R. C. Shekhar, N. Kumar, L. Dar, J. C. Samantaray, S. K. Sharma, A. Bhargava, R. M. Pandey, R. L. Mitsuyasu, J. L. Fahey

“…The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR). In this study we aim to evaluate the prevalence of HIVDR mutations in ART-naive HIV-1 infected patients from northern India. …”
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Prevalence of Transfusion Transmitted Virus Infection in Hemodialysis Patients and Injection Drug Users Compared to Healthy Blood Donors in Isfahan, Iran by Behrooz Ataei, Alireza Emami Naeini, Farzin Khorvash, Mohammad Reza Yazdani, Abbas-Ali Javadi

“…The aim of this study was to determine the prevalence of TTV in hemodialysis patients, injecting drug users (IDUs), and healthy blood donors, in Isfahan, Iran. …”
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Machine learning-based prediction of antipsychotic efficacy from brain gray matter structure in drug-naive first-episode schizophrenia by Xiaodong Guo, Enpeng Zhou, Xianghe Wang, Bingjie Huang, Tianqi Gao, Chengcheng Pu, Xin Yu

“…A cohort of 104 drug-naive FES was recruited. Before initiating treatment, T1-weighted anatomical images were captured. …”
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Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psoriasis by Martina Morelli, Claudia Scarponi, Laura Mercurio, Francesco Facchiano, Sabatino Pallotta, Stefania Madonna, Giampiero Girolomoni, Cristina Albanesi

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Nanoarchitectonics of Biofunctionalized Hydrogen‐Terminated 2D‐Germanane Heterostructures as Highly Sensitive Biorecognition Transducers: The Case Study of Cocaine Drug by Yiming Lei, Ángel Campos‐Lendínez, Xavier Sala, Jordi García‐Antón, Jose Muñoz

“…After an accurate material characterization, the resulting ssDNA/Au@GeH heterostructure is drop‐casted on a fluorine‐doped tin oxide (FTO) electrode for impedimetrically monitoring cocaine as a model drug. Interestingly, the aptamer–cocaine interactions hinder the interfacial electron‐transfer process of the benchmark [Fe(CN)6]3−/4− redox marker with increasing concentration of the cocaine target, leading to a detection limit as low as 4.9 ± 0.1 aM, the lowest one reported in literature by far. …”
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Comparing multivalent cross-linked Sodium Alginate/ Montmorillonite beads containing Curcumin or Cayenne Pepper as drug carriers and their antimicrobial resistance by Shionainn Traynor, Shubham Sharma

Subjects: “…controlled drug delivery; antibacterial; curcumin; cayenne pepper; sodium alginate…”
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Sex-Related Effects of Adrenergic Drugs on Conditioned Pain Modulation: A Randomized Controlled Cross-Over Double-Blind Trial by Marie-Philippe Harvey, Marie-Chantal Dubois, Philippe Chalaye, Yanick Sansoucy, Serge Marchand

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Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery by Cynthia Koziol-White, Eric Gebski, Gaoyaun Cao, Reynold A. Panettieri

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Salt Stress Enhanced Bioactivity of Quinoa Leaf Extracts: An In Vitro and In Silico Study of Acetylcholinesterase and Tyrosinase Inhibition for Sustainable Drug Development by Narmine Slimani, Soumaya Arraouadi, Hafedh Hajlaoui, Antonio Cid-Samamed, Mohamed Ali Borgi, Mejdi Snoussi

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Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release by Jinjing Xing, Yeqiang Cai, Yikun Wang, Haifu Zheng, Yujia Liu

“…In this paper, we use mesoporous CaCO3 nanoparticles as intelligent carrier, sodium alginate, and chitosan as alternating assembly materials, folic acid as target molecules, and exploit layer-by-layer assembly technology to achieve sensitive molecular targeting and pH response drug release. Mesoporous CaCO3 hybrid nanoparticles have high drug loading on doxorubicin. …”
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Preparation and Characterization of PEG4000 Palmitate/PEG8000 Palmitate-Solid Dispersion Containing the Poorly Water-Soluble Drug Andrographolide by Qingyun Zeng, Liquan Ou, Guowei Zhao, Ping Cai, Zhenggen Liao, Wei Dong, Xinli Liang

“…Solid dispersion (SD) is the effective approach to improve the dissolution rate and bioavailability of class II drugs with low water solubility and high tissue permeability in the Biopharmaceutics Classification System. …”
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Treatment outcomes among children and adolescents with extensively drug-resistant (XDR) and pre-XDR tuberculosis: Systematic review and meta-analysis. by Jayadeep Patra, Hyacinth Irving, Pranshu Maini, Jady Liang, Anwesh Patra, Mandar Paradkar, Jurgen Rehm

“…Extensively drug-resistant (XDR) and pre-XDR- tuberculosis (TB) account for approximately a third of pediatric MDR-TB cases globally. …”
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Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum by Yunliang Zheng, Nana Xu, Xingjiang Hu, Qiao Zhang, Yanpeng Liu, Qingwei Zhao

“…This method was successfully applied to the quantification of four first-line antituberculosis (anti-TB) drugs, suggesting its suitability for therapeutic drug monitoring in the clinical practices.…”
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Sex differences in the peripheral levels of cytokines during 12-month antipsychotic treatment in a drug-naïve schizophrenia spectrum cohort by I. Ratke, A. Torsvik, C.A. Bartz-Johannessen, F. Fathian, I. Joa, S.M. Klæbo Reitan, E.M. Løberg, M. Rettenbacher, S. Skrede, V.M. Steen, E. Johnsen, R.A. Kroken

“…Interpretation: We found significant sex differences in serum cytokine changes in drug-naïve patients with schizophrenia during treatment with antipsychotics. …”
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Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients by Esmat Khaleqsefat, Khder Hussein Rasul, Ramiar Kamal Kheder, Sonia Baban, Jamil Baban

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