An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…The recombinant protein would be produced and released only in the presence of the inciting stimulus, avoiding immunosuppression or other unwanted side effects that may occur when treating infectious diseases with anti-inflammatory drugs. To test this hypothesis, we developed AdV.C3-Tat/HIV-Box A, an inflammation-inducible cassette that remains innocuous in the absence of inflammation but releases HMGB1 Box A, an antagonist of high mobility group box 1 (HMGB1), in response to inflammatory stimuli such as lipopolysaccharide (LPS) or influenza virus infection. …”
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Exploring the impact of deleterious missense nonsynonymous single nucleotide polymorphisms in the DRD4 gene using computational approaches by Dipto Kumer Sarker, Pallobi Ray, Fayad Bin Abdus Salam, Shaikh Jamal Uddin

“…Overall, this study revealed five novel deleterious variants along with a comprehensive understanding of their effect in the presence of an agonist and antagonist, which could be helpful for understanding disease susceptibility, precision medicine, and developing potential drugs.…”
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Pharmacogenetics: Influence of CYP2C9*2 and *3 alleles polymorphisms on Iraqi type 2 diabetic patients by Ghada S. Rasool, Asmaa A. Hussien, Suhad R. Al-Tayie, Salwa J. Al-Awadi, Hussein OM Al-Dahmoshi

“…Abstract Background: Sulfonylureas (SUs) are the most prescribed anti-diabetic drugs. The enzyme responsible for metabolizing of SUs is hepatic cytochrome P4502C9 (CYP2C9). …”
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Identification of prognostic biomarker of non-small cell lung cancer based on mitochondrial permeability transition-driven necrosis-related genes and determination of anti-tumor ef... by Zhifei Ma, Wen Chen, Aiping Zhang, Xiaokang Shen, Lin Zheng

“…Three gene were strongly associated with most immune cells, immune checkpoints, and drugs sensitivity. RT-qPCR confirmed that expression levels of three genes in tissues or cells were consistent with the results of bioinformatics analysis. …”
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Grafiti: exposición de la religiosidad de las pandillas de San Luis Potosí by Jaime Bernal Boyzo

“…In this way, under this divine protective mantle found in both Catholic images, the sale of drugs, mugging of bystanders, and house burglary, which are some of the illicit activities by these gang members, become actions of claim and justice that they take against an unfair society that condemns them to live in extreme misery and great poverty.…”
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Hubungan Derajat Nyeri Dismenorea terhadap Penggunaan Obat Anti Inflamasi Non Steroid by Mutya Restu Ayu, Yustini Alioes, Rahmatini .

“…The most chosen therapy is Non-steroidal anti-inflammatory drugs (NSAIDs). The objective of this study was to assess the correlation between the pain intensity level of dysmenorrhea with the use of NSAIDs. …”
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Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis by Li L, An G, Li F, Zhang D, Zhu X, Liang C, Zhao Y, Xie K, Zhou P, Zhu H, Jin X, Du L

“…Rimegepant, eptinezumab, methotrexate, atogepant, and ubrogepant were identified as potential drugs for S100A12 and S100A8 in patients with UC and AS. …”
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy by Dandan Zhu, Peng Wang, Xiyue Chen, Kaituo Wang, Yunsong Wu, Min Zhang, Jianhua Qin

“…In addition, the SAE mouse model was utilized to determine the state of glial cells and evaluate the therapeutic effect of drugs targeting the astrocyte–microglia crosstalk in vivo. …”
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Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers by Bill Liao, Christine Tumanut, Lin Li, Adam Corper, Dilip Challa, Alex Chang, Hydari Begum, Elinaz Farokhi, Catherine Woods, Xiaomin Fan

“…Cell engager antibody formats that recruit and activate NK cells more effectively have emerged as a promising immunotherapy approach to target cancer cells through more effective antibody-dependent cell-mediated cytotoxicity (ADCC). Monoclonal antibody drugs with ADCC activity have shown clinical benefit and improved outcomes for patients with certain types of cancer. …”
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The Effect of Chicory Consumption on Oxidative Stress Indices of the Kidney Tissue in Female Wistar Rats Consuming Testosterone Enanthate during eight weeks Resistance Training by Khadijeh Molaei, Sanaz Mirzayan Shanjani, Ali Gorzi, Yaser Kazemzadeh, Abdolali Banaeifar

“…Background and Aim: Testosterone enanthate is one of the common drugs among female athletes, and one of its basic side effects is the oxidative stress increase. …”
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Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial. by Menglu Ouyang, Anila Anjum, Francisca Gonzalez Mc Cawley, Mohammad Wasay, Lu Ma, Xin Hu, Xiaoying Chen, Alejandra Malavera, Xi Li, Paula Muñoz Venturelli, H Asita de Silva, Nguyen Huy Thang, Kolawole W Wahab, Jeyaraj D Pandian, Octavio M Pontes-Neto, Carlos Abanto, Venessa Cano-Nigenda, Antonio Arauz, Chao You, Stephen Jan, Lili Song, Craig S Anderson, Hueiming Liu, INTERACT3 Investigators

“…Contextual factors including staff shortage, limited availability of antihypertensive drugs, and delayed systems of care processes, were common barriers to implementing the Care Bundle. …”
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Safety during surgical resection of the sclera in patients with primary and secondary glaucoma by A.Yu. Kazantzeva, E.A. Korchuganova

“…All patients received topical maximally tolerated antihypertensive therapy before surgery (on average, 4 drugs individually and in the form of fixed combinations). …”
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Separate Evaluation of the Effects of Hydroalcoholic Extracts of Eryngium Caucasicum L. and Zataria Multiflora L. on Gastric Ulcers in an Animal Model by mahdi Jalahi, Mohammad Azadbakht, Jafar Akbari, Fereshteh Talebpuor, Fatemeh Akbari

“…Background and purpose: The aging population and its associated complications, such as chronic pain, have led to an increased use of non-steroidal anti-inflammatory drugs (NSAIDs) like indomethacin. However, indomethacin is associated with notable side effects, particularly gastric ulcers. …”
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Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs by Jost Klawitter, Mckay Easton, Alexander Karpeisky, Kristen B. Farrell, Douglas H. Thamm, Touraj Shokati, Uwe Christians, Shawn Patrick Zinnen

“…The use of the bone-seeking properties of bisphosphonates (BPs) to target the delivery of therapeutic drugs is a promising approach for the treatment of bone metastases. …”
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Impact of political conflict on tuberculosis notifications in North-east Nigeria, Adamawa State: a 7-year retrospective analysis by Nguyen Lam Vuong, Kenji Hirayama, Nguyen Tien Huy, Luis E Cuevas, Emmanuel Pembi, Stephen John, Shyam Prakash Dumre, Baba Usman Ahmadu, Amr Ebied, Shusaku Mizukami

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Implementation of Virtual and Face-to-Face Childbirth Preparation Training for the Spouses of the Primiparous Women to Reduce the Fear of Childbirth, Improve the Pregnancy Experien... by Zari Doaltabadi, Leila Amiri-Farahani, Seyedeh Batool Hasanpoor-Azghady

“…The exclusion criteria for women’s husbands are the history of physical/mental illness; being a smoker; and consuming alcohol, drugs, or psychotropic substances. The participants will be selected by the convenience sampling method and will be divided into three groups of study A, study B, and control. …”
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Antibiotic Prophylaxis Prescribing Practices for Dental Implant Placement in Croatia: A Questionnaire-Based Cross-Sectional Study by Mare Ković, Ajka Pribisalić, Joško Viskić, Jure Martinić, Josipa Grubišić, Ante Vardić, Tina Poklepović Peričić

“…Also, the dentists reported using antibiotics in patients with artificial joints (N = 52, 69.3%), diabetes (N = 48, 64%), HIV (N = 51, 34.2%), or those on antiresorptive drugs (N = 46, 61.3%), with 17 dentists (22.7%) prescribing antibiotics to all (<i>p</i> < 0.001). …”
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Evaluating the safety and effectiveness of α-blockers versus mirabegron for medical expulsive therapy in ureteral calculi: A Systematic review and meta-analysis. by Huilei Yan, Xiaoni Li, Xiaobo Zheng, Yuanshan Cui, Jing Huang, Yan Cheng

“…<h4>Introduction and aim</h4>The main categories of drugs employed for medical expulsive therapy in patients with ureteral calculi (UC) are alpha-blockers (α-B) and beta-adrenoceptor agonists. …”
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Diagnosis and treatment of descending optic neuritis developed as a manifestation of local viral encephalitis (a clinical case) by N.V. Korsakova, E.I. Korsakova

“…It should be recognized that during the process of opticoencephalitis development, its ophthalmic manifestations for a long time will not only remain a single sign of this focal neurological disorder, but will require timely initiation of etiotropic drugs, using the appropriate routes of administration, doses, and duration of treatment. …”
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Impact of urbanisation on the gaps of hypertension prevalence, awareness and treatment among older age in China: a cross-sectional study by Qiutong Yu, Genyong Zuo

“…Objectives To examine the impact of urbanisation on the prevalence, awareness and treatment of hypertension among elderly in China.Design This cross-sectional study used data from the most recent nationally representative Chinese Longitudinal Healthy Longevity Survey, 2018.Setting People in urban and rural communities from 500 sample areas in 22 Chinese provinces.Participants After exclusion, this study surveyed 9859 participants in the final analysis.Primary and secondary outcome measures The main dependent variables were prevalence, awareness and treatment of hypertension defined as (1) systolic blood pressure (BP)≥140 mm Hg, diastolic BP≥90 mm Hg or (2) taking antihypertensive drugs. Hypertension awareness was defined as a previous diagnosis of hypertension by a health professional, and hypertension treatment was defined as undergoing BP treatment.Results The prevalence of hypertension was lower among semiurbanised adults than among non-urbanised rural adults (OR=0.94, 95% CI=0.90 to 0.99; p&lt;0.05). …”
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