Gabapentin versus Transdermal Fentanyl Matrix for the Alleviation of Chronic Neuropathic Pain of Radicular Origin: A Randomized Blind Multicentered Parallel-Group Noninferiority Tr... by Chang Ju Hwang, Jae Hyup Lee, Jung-Hoon Kim, Sang Hyuk Min, Kun-Woo Park, Hyoung-Yeon Seo, Kwang-Sup Song

“…In the primary analysis, the noninferiority of fentanyl matrix treatment was evaluated in relation to the efficacy of gabapentin based on the pain intensity difference (PID) at 56 days after the first dose of the drugs. Secondary endpoints included pain relief, improvement in functional status (the Korean-Oswestry Disability Index (K-ODI)), improvement in depressive symptoms (Korean-Beck Depression Index (K-BDI)) between the 28th and 56th day, and adverse events (AEs). …”
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Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis by Yuan Xu, Hongfei He, Haiyang Li

“…Finally, we examined the regulatory network of screened key genes that interact with RNA-binding proteins, potential drugs, small-molecule compounds, and transcription factors. …”
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Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation by Md Ruhul Amin, Lakhan Khara, Joshua Szaszkiewicz, Andrew M. Kim, Trevor J. Hamilton, Declan W. Ali

“…Abstract Cannabis is one of the most widely used drugs, and yet an understanding of its impact on the human brain and body is inconclusive. …”
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A clinical study on the efficacy and safety of poly-herbal formulation in managing functional dyspepsia by Debasish Hota, Anand Srinivasan, Manas Kumar Panigrahi, Snigdha Suman Dalua, Poorva Tiwari, Ramachandran Valavan

“…Since the synthetic anti-dyspeptic drugs like proton pump inhibitors are known to have adverse effects, this natural alternative PHF shows promising results in a safer way. …”
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Dual Biologic or Small Molecule Therapy in Pediatric Inflammatory Bowel Disease: A Single Center Experience by Cheng Guo, Jin Zhou, Guoli Wang, Jie Wu

“…The purpose of this study was to evaluate the efficacy and safety of dual biologic therapy or biologics combined with small molecule drugs in refractory PIBD patients in China. Methods: Clinical, laboratory, endoscopic, and ultrasound data of PIBD patients from the Department of Gastroenterology of Beijing Children’s Hospital between January 2021 and October 2024 were retrospectively analyzed. …”
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Blood Pressure Control among Hypertensive Diabetic Patients on Follow-Up at Chronic Clinic of Nekemte Referral Hospital in West Ethiopia by Mohammed Gebre Dedefo, Dureti Bayisa Gemechu, Ginenus Fekadu, Tesfa Tekle Dibessa

“…A cross-sectional study was conducted among hypertensive adult patients comorbid with diabetes taking antihypertensive drugs for at least one year in NRH. Both bivariable and multivariable analyses were done. …”
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A prospective, longitudinal, comparative analysis of the World Health Organization / International Committee of the Red Cross Basic Emergency Care Course on emergency medicine know... by Nichole Michaeli, Andrew Beck, Giovanna De Luca, Mary Gitau, Derek Lubetkin, Derick Ochieng, Grace W. Wanjiku, Justin G. Myers

“…On follow-up evaluation, BEC participants reported a significant decrease in confidence in understanding emergency drugs and managing an obstructed airway and a patient requiring immobilization. …”
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Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection by Yong-yu Mei, You-ming Chen, Yuan-kai Wu, Xiao-hong Zhang, Wen-xiong Xu

“…Patients infected with GT 3/6 HCV and treated with SOF-based DAAs were enrolled in this prospective, open, single-center, and real-world study. Drugs included Sofosbuvir (SOF), Velpatasvir (VEL), Daclatasvir (DCV), and Ribavirin (RBV). …”
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Correlation of macronutrient and micronutrient intake with anemia status in pulmonary tuberculosis patients at namorambe community health center by Aritonang Evawany Yunita, Manalu Sarah Patumona, Manalu Samuel MH

“…This research shows that the majority of respondents adhere to taking anti-tuberculosis drugs with moderate and high compliance levels of 30% and 63.3% respectively. …”
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Assessing feasibility and acceptability of increasing access to sexual and reproductive health and rights through pharmacy outlets and community health volunteers: lessons from pil... by Wilson Liambila, Francis Obare, Saumya RamaRao, Monica Oguttu, Carol Nyandat, Benedict Denga, Zeka Wekesa

“…Results A total of 527 clients obtained medication abortion drugs from the 9 participating pharmacy outlets between April and December 2022. …”
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Differentiated approach at the choice of chronic hepatitis C antiviral therapy mode (real clinical practice experience) by I. Yu. Pirogova, N. B. Kovaleva, E. P. Patlusov, E. S. Radchenko

“…The treatment mode and dose of drugs conformed to the existing standards. Treatment response was defined by the frequency of sustained virologic response (SVR) achievement. …”
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Clinical Holistic Medicine (Mindful,Short-Term Psychodynamic Psychotherapy Complemented with Bodywork) in the Treatment of Experienced Mental Illness by Søren Ventegodt, Suzette Thegler, Tove Andreasen, Flemming Struve, Lars Enevoldsen, Laila Bassaine, Margrethe Torp, Joav Merrick

“…For the treatment responders, the treatment provided lasting benefits, without the negative side effects of drugs. A lasting, positive effect might also prevent many different types of problems in the future.…”
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A meta-analysis of risk factors for cardiovascular adverse events with anthracycline based chemotherapy in lymphoma patients by Bo Dai, Jingjing Xu, Baiyan Wang

“…Conclusions Our research findings indicate that patients with a history of hypertension, radiation therapy, diabetes, smoking, and elderly individuals are at an elevated risk of cardiovascular disease in the process of administration of anthracycline drugs. Consequently, careful case selection and condition monitoring are important in the treatment process. …”
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Impact of non-participation bias due to psychiatric illness on mortality and cardiovascular event estimates: a Danish longitudinal population study by Christian Torp-Pedersen, Mads Rasmussen, Christina Ellervik, Anders Jorgensen, Henrik E Poulsen, Zerlina Rygner

“…Overall, more non-participants used psychotropic drugs than participants (1.26 (1.21 to 1.31)), and psychiatric non-participants had higher psychiatric hospital service utilisation than psychiatric participants. …”
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Sodium-Glucose Cotransporter-2 (SGLT-2) Attenuates Serum Uric Acid (SUA) Level in Patients with Type 2 Diabetes by Mazhar Hussain, Asim Elahi, Abid Hussain, Javed Iqbal, Lubna Akhtar, Abdul Majid

“…The goal of this study was to compare the effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors dapagliflozin and empagliflozin on serum uric acid (SUA) levels in patients with type 2 diabetes against traditional oral antihyperglycemic drugs (OADs). Methods. In this double-blind randomized controlled trial, 70 patients with type 2 diabetes and elevated SUA levels were assigned to two treatment groups. …”
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Assessment of Blood Pressure Control Status Among Hypertensive Patients Attending Rwandan District Hospital NCD Clinics: A Retrospective Follow-Up Study by Evariste Ntaganda, Ziad El-Khatib, Regine Mugeni, Boniface Nsengiyumva, Clarisse Musanabaganwa, James Gafirita, Francois Uwinkindi, Richard Kalisa

“…Factors significantly associated with uncontrolled BP included BMI ≥ 30 kg/m2 (p < 0.001), use of Angiotensin-converting enzyme (ACE) inhibitors (p = 0.01), use of four antihypertensive drugs (p = 0.013), and missing an NCD clinic appointment (p < 0.001). …”
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Population characteristics, prescription patterns and glycemic control of users of flash glucose monitoring systems in Brazil: a real-world evidence study by Karla Santo, Josué Nieri, Karine Risério, Karla F. S. Melo

“…Compared to BGM, fCGM users were significantly younger, had a higher proportion of males, resided more frequently in the Southeast region of Brazil, had a lower BMI, a longer time since diagnosis, and used Glic™ platform more frequently. fCGM users were prescribed significantly more ultra-long and ultra-rapid acting insulins as their basal and bolus insulin, respectively, and less oral anti-diabetics drugs compared to BGM users. Considering only the T1DM and LADA individuals and their manual glucose inputs, fCGM users had non-significant lower glucose levels than BGM. …”
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Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer&rsquo;s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…Moreover, the relationship between hub biomarkers and immune infiltration was assessed using CIBERSORT, and the potential drugs or small molecules associated with the core biomarkers were identified via the DGIdb database.Results: MR analysis showed that KI may be a risk factor for AD. …”
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Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study by Michael Che, Sumaiya Ahmed, Ryan Chan, Ayub Akbari, Deborah Zimmerman

“…Measurements: Number of patients prescribed antiplatelets, PPIs, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids; indications for aforementioned medications. …”
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Heterologous Expression of a Potential ‘<i>Paulownia fortunei</i>’ MYB Factor Gene, <i>PfMYB90</i>, Improves Salt and Cold Tolerance in <i>Arabidopsis</i> by Hongling Wang, Shizheng Shi, Guijie Luo, Ruifang Huang, Dezong Sui, Yunpeng Gao, Lei Wang

“…Paulownia has strong vitality; has strong adaptability to harsh environmental conditions; and can be used as building raw material, as well as processing drugs and having other purposes. In the research field of MYB transcription factors of the paulownia tree, it is rare to discuss the resistance to abiotic stress. …”
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