ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…Ferroptosis indicators, including levels of reactive oxygen species, were used to detect the combined effect of CAR-T cells and ferroptosis-inducing drugs. Finally, tumor-bearing mice were used to validate the in vivo efficacy of the combination therapy strategy. …”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Further researches on SCO may help understand its in-depth mechanisms of action and pave the way for the development of novel drugs to prevent and treat various immune-mediated inflammatory disorders as well as hepatic diseases, thereby significantly advancing its innovations and pharmaceutical applications.…”
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Impact of duration of treatments with metformin and sulfonylureas, individually or in combination, on diabetic retinopathy among newly diagnosed type 2 diabetic patients: a pooled... by Mansour Bahardoust, Yadollah Mehrabi, Farzad Hadaegh, Davood Khalili, Ali Delpisheh

“…These findings highlight the protective role of metformin and sulfonylureas as inexpensive and readily available drugs to prevent DR in people with newly diagnosed diabetes.…”
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Assessment of Risk Factors of Chronic Kidney Disease among Patients Attending Medical City Complex by Nabaa Wisam Sabri, Buthaina Ateyah Rashid, Raheem Saber Shwiehk, Azad H. Mahdy

“…Increased intake of antihypertensive medical drugs also increases the risk of CKD (p. value =0.000). …”
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Hsa-miR-105-1 Regulates Cisplatin-Resistance in Ovarian Carcinoma Cells by Targeting ANXA9 by Xinxin Kou, Hui Ding, Lei Li, Hongtu Chao

“…Cisplatin is one of the most effective drugs for treating ovarian carcinoma (OC), which is among the most lethal types of carcinoma. …”
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Awareness and perception of prevention and management options of sexually transmitted infections among students at secondary school in Rivers State, Nigeria by Florence Mandah, Oluebubechukwu Udi, Pamela Thompsom-Abiye, Basil Ogbu

“…Results 99.3% of participants agreed that STIs can be treated with pharmaceutical drugs, 33% believed in the effectiveness of local concoctions, while 68.3% indicated that divine intervention of prayers offers a cure. 290 (96.6%) participants strongly agreed that young people should be educated on STIs in schools. …”
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The heterogeneity of NOTCH1 to tumor immune infiltration in pan-cancer by XiaoJun Duan, Rihan Wu, Mingyang Zhang, Kexin Li, Lei Yu, Huirong Sun, Xingxia Hao, Changshan Wang

“…We further analyzed the changes of immune infiltration in pan-carcinoma species from the perspectives of NOTCH1 expression, mutation, gene function, tumor metastasis and drugs. NOTCH1 expression was significantly up-regulated in cold tumors but down-regulated in hot tumors. …”
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Antibacterial and photocatalytic activities of biosynthesized zinc oxide nanoparticle using novel plant P. macrosolen L. leaf extract by Abel Saka Gungure, Leta Tesfaye Jule, N. Nagaprasad, Krishnaraj Ramaswamy, Shanmugam Ramaswamy

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Can the adherence to quality of care indicators for early rheumatoid arthritis in clinical practice reduce risk of hospitalisation? Retrospective cohort study based on the Record L... by Carlo Alberto Scirè, Antonella Zambon, Greta Carrara, Anna Zanetti, Lisa Argnani

“…Objective To describe the adherence to quality of care indicators in early rheumatoid arthritis (RA) and to evaluate its impact on the risk of hospitalisation in a real-world setting.Design Retrospective cohort study.Setting Patients with early-onset RA identified from healthcare regional administrative databases by means of a validated algorithm between 2006 and 2012 in the Lombardy region (Italy).Participants The study cohort included 14 203 early-onset RA (71% female, mean age 60 years).Outcome measures For each patient, a summary adherence score was calculated starting from the compliance to six quality indicators: (1–2) methotrexate or sulfasalazine or leflunomide with/without glucocorticoids, (3–4) other disease-modifying antirheumatic drugs (DMARDs) with/without glucocorticoids, (5) early interruption of glucocorticoids, (6) early clinical assessment.The relationship between low, intermediate and high categories of the summary score and the 12-month risk of hospitalisation for all causes and for RA was assessed.Results During a follow-up of 1 year, 2609 hospitalisations occurred, of which 704 were for RA (main or secondary diagnosis) and 252 primarily for RA. …”
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The Prevalence and Diagnostic Ratio of Familial Hypercholesterolemia (FH) and Proportion of Acute Coronary Syndrome in Japanese FH Patients in a Healthcare Record Database Study by Tamio Teramoto, Tomohiro Sawa, Satoshi Iimuro, Hyoe Inomata, Takashi Koshimizu, Iori Sakakibara, Katsutoshi Hiramatsu

“…The primary endpoint was the prevalence of definite or suspected FH; secondary endpoints included the proportion of FH patients hospitalized for ACS, the proportion of patients using lipid-lowering drugs (LLDs), and LDL-C levels. Results. Of the 187,781 patients screened, 1547 had definite or suspected FH (0.8%) based on data from the entire period; 832 patients with definite (n=299, 0.16%) or suspected FH (n=533, 0.28%) before the index date were identified in the main analysis cohort. …”
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A comparative study on the efficacy of over-the-counter wax solvents versus distilled water for managing ear cerumen by Syed. Mohd. Ahmad, Rajesh Kumar Suman, Simran Kaur Pal, Ayush Agrawal

“…Mild post-interventional pain was managed with an as-needed dosage of nonsteroidal anti-inflammatory drugs Statistically significant differences were observed in the study parameters between the subjects of the two groups. …”
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Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…**Methods:** Children were enrolled in this 24-month observational, multicentric, cross-sectional, retrospective study (N = 107) if they had been treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs), had participated in a previous study (ITACA), and continued to be followed up at pediatric rheumatology units at 3 tertiary Spanish hospitals. …”
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Integrative analyses of mendelian randomization and bioinformatics reveal casual relationship and genetic links between COVID-19 and knee osteoarthritis by Xiao Zheng, Jinhao Li, Qinfeng Ma, Jianping Gong, Jianbo Pan

“…Imatinib, Adiponectin, Myricetin, Tranexamic acid, and Chenodeoxycholic acid are potential drugs for the treatment of KOA patients with COVID-19. …”
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Three effective cases of transcatheter arterial embolization after atezolizumab and bevacizumab treatment for hepatocellular carcinoma: a case report by Koji Rinka, Kiyohide Kioka, Yuga Amano, Takashi Nakai, Yasuko Kawasaki, Norifumi Kawada

“…He started treatment with atezolizumab and bevacizumab but developed grade 3 liver injury after two courses, leading to the discontinuation of these drugs and subsequent bland transcatheter arterial embolization. …”
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Graphene-Based Materials for Bone Regeneration in Dentistry: A Systematic Review of In Vitro Applications and Material Comparisons by Azahara María Narváez-Romero, Francisco Javier Rodríguez-Lozano, María Pilar Pecci-Lloret

“…Additionally, its ability to act as an effective carrier for growth factors and drugs allows controlled release, facilitating the engineering of specific tissues for bone regeneration. …”
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Cultures as types and the utility of viable specimens for fungal nomenclature by Andrey Yurkov, Cobus M. Visagie, Pedro W. Crous, Akira Hashimoto, Christiane Baschien, Dominik Begerow, Martin Kemler, Nathan Schoutteten, Marc Stadler, Nalin N. Wijayawardene, Kevin D. Hyde, Ning Zhang, Teun Boekhout, ICTF Yeast Working Group, Tom W. May, Marco Thines, David L. Hawksworth

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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells by S. González-Ochoa, M. C. Tellez-Bañuelos, A. S. Méndez-Clemente, A. Bravo-Cuellar, G. Hernández Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sánchez-Reyes, P. C. Ortiz-Lazareno

“…Advanced stages of the disease are usually very aggressive, and most are treated with chemotherapeutic drugs that generally cause side effects in these patients. …”
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Prediction of oral diseases in care dependent older people by Christina Andersen, Astrid Pernille Jespersen, Kim Ekstrand, Esben Boeskov Øzhayat

“…A significant association was also found between poor oral hygiene and taking psychotropic drugs (OR, 2.61; CI, 1.08–6.30). Conclusion Questions regarding the use of the dental care system and oral health problems could be used by nondental care staff in conversations with older people to determine their risk of oral diseases and poor oral hygiene.…”
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Total hip arthroplasty in hip tuberculosis: a systematic review by Shengyuan Zheng, Mufeng Li, Hong Chen, Yanguo Qin

“…In general, physicians are accustomed to deciding the appropriate timing of surgery based on inflammatory markers; 90% of the studies recommended preoperative and postoperative antituberculosis therapy (ATT), and 14 studies used antituberculosis drugs during surgery. The majority of the studies used single-stage surgery, and 6 studies used two-stage surgery; cemented prostheses were used in 19.6% of the surgeries, cementless prostheses were used in 79.5% of the surgeries, and hybrid fixation was used in 0.9% of the surgeries. …”
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The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomize... by Kinga Kovács, Rita Nagy, Lilla Andréka, Brigitta Teutsch, Miklós Szabó, Péter Varga, Péter Hegyi, Péter Hársfalvi, Nándor Ács, Ágnes Harmath, Csaba Nádor, Ákos Gasparics

“…Since the Caffeine Therapy for Apnea of Prematurity (CAP) trial, caffeine has become one of the essential drugs at NICUs. However, the optimal dosage and timing for adequate effectiveness still need to be more conclusive. …”
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