Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD by Maojia Ran, Hang Zhang, Meijiang Jin, Yuanmei Tao, Hanmei Xu, Shoukang Zou, Zhujun Wang, Fang Deng, Lijuan Huang, Hong Zhang, Xiaowei Tang, Yanping Wang, Xia Fu, Li Yin, Li Yin, Li Yin

“…The aim of this study is to investigate whether dFC patterns will be changed by antidepressant treatment, as well as whether baseline dFC pattern could predict treatment response in adolescent MDD patients.MethodWe included 35 drug-naïve, first-episode MDD adolescents (age 14.40 ± 1.24; 8 males and 27 females) and 24 healthy controls (HCs, age 14.21 ± 1.41; 11 males and 13 females). …”
Get full text

DTI-MHAPR: optimized drug-target interaction prediction via PCA-enhanced features and heterogeneous graph attention networks by Guang Yang, Yinbo Liu, Sijian Wen, Wenxi Chen, Xiaolei Zhu, Yongmei Wang

“…Abstract Drug-target interactions (DTIs) are pivotal in drug discovery and development, and their accurate identification can significantly expedite the process. …”
Get full text

Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study by Ying Tan, Juan Tan, Cheng Luo, Wenjuan Cui, Hui He, Yi Bin, Jiayan Deng, Rui Tan, Wenrong Tan, Tao Liu, Nanlin Zeng, Ruhui Xiao, Dezhong Yao, Xiaoming Wang

Get full text

Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

“…BackgroundConducting clinical drug trials (CTs) with children presents several challenges. …”
Get full text

Harnessing the power of structure‐based design: A new lease on life for cardiovascular drug development with apelin receptor modulators by Junxia Zhang, Erdan Dong, Yan Zhang, Yan Zhang

Get full text

Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan by Emilia Szymańska, Anna Czajkowska-Kośnik, Katarzyna Winnicka

“…Viscosity variations upon storage influenced markedly mucoadhesive properties and drug release rate from hydrogels.…”
Get full text

Drug‐Induced Cauda Equina Syndrome in an 8‐Year‐Old Boy With Acute Lymphoblastic Leukemia: An Uncommon Case Report by Marzieh Babaee, Mohsen Javadzadeh, Ali Hazeghi

Get full text

Risk assessment of look‒alike, sound‒alike (LASA) medication errors in an Italian hospital pharmacy: A model based on the ‘Failure Mode and Effect Analysis’ by Nestor Ciociano, Lucilla Grisi, Lucia Bagnasco, Maria Giovanna Elberti, Marcello Mazzarella

Subjects: “…risk management; risk assessment; LASA drugs; drug safety; FMEA; patient safety.…”
Get full text

Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

Subjects: Get full text

Evaluating maternal drug use disparities, risk factors and outcomes in Northeast Arkansas: a pre, during, and post-COVID-19 pandemic analysis by Enrique Gomez Pomar, Johnna Berryhill, Sudeepa Bhattacharyya

Subjects: “…Perinatal drug use…”
Get full text

In-situ biophysical characterization of high-concentration protein formulations using wNMR by Jing Song, Marc Taraban, Y. Bruce Yu, Lynn Lu, Pallavi Guha Biswas, Wei Xu, Hanmi Xi, Akhilesh Bhambhani, Guangli Hu, Yongchao Su

Subjects: Get full text

UAE pharmacists’ perceptions of the causes of unwanted or unused medications, their practices, and barriers to promoting safe medication disposal by the public by Maram O. Abbas, Semira Beshir, Doaa Kamal AlKhalidi, Eiman Shamseldin Al Gailani Ali, Yosra Lozon, Rizah Anwar Assadi, Hana Ghdaiba, Rahaf Adnan AL-Zeer

Subjects: Get full text

Impact of psychotropic pro re nata prescription-monitoring programme on prescriptions for inpatients with psychiatric disorders: a retrospective observational study by Yoshitaka Saito, Kyohei Sumida, Hiroyuki Muraoka, Satoru Oishi, Ryutaro Suzuki, Taiyo Nishikawa, Shin Miyake, Yukihiro Tanno, Yuki Tobita, Katsuya Otori, Ken Inada

Subjects: Get full text

Enhancement of in vitro antitumour activity of epirubicin in HER2+ breast cancer cells using immunoliposome formulation by Farnaz Khaleseh, Abbas Hemmati Azandaryani, Fatemeh Fathian Kolahkaj, Mozafar Khazaei, Katayoun Derakhshandeh

Subjects: Get full text

Nano–bio surface interactions, cellular internalisation in cancer cells and e‐data portals of nanomaterials: A review by Ram Dhan Yadav, Abha Chaudhary

Subjects: Get full text

One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment by Zhongxing Miao, Yujie Wang, Shengjie Li, Min Zhang, Meng Xu

Subjects: Get full text

Consumer’s Knowledge, Attitude, and Practices toward Self-medication: Questionnaire Development and Validation by Nahid Ansari, Abhishek Dadhich

Subjects: Get full text

Comparative Effectiveness of Anti-Inflammatory Drug Treatments in Coronary Heart Disease Patients: A Systematic Review and Network Meta-Analysis by Ivan Wudexi, Elica Shokri, Mohamed Abo-Aly, Kazuhiro Shindo, Ahmed Abdel-Latif

“…Overall, there is no statistically significant difference in all-cause mortality, cardiovascular mortality, revascularization, and major cardio and cerebrovascular events (MACCE) with the use of anti-inflammatory drugs. However, we found the use of colchicine significantly reduces the odds of developing stroke by approximately 75% (OR 0.26, CI 0.10-0.63). …”
Get full text

Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data by Sungmin Jung, Jack Bufton, Zeqing Bao, Wonjoon Cho, Dean Aguiar, Christine Allen

“…A long-acting delivery system could provide several advantages as a formulation strategy for this drug including improved patient adherence, convenience, more consistent drug levels and potentially fewer side effects. …”
Get full text