Adaptation of the five-factor BFI-10 personality screening questionnaire and testing of its diagnostic properties on the example of drug users by О. О. Serdiuk, В. О. Bazyma

“…The BFI-10 adapted variant has showed its diagnostic applicability in a study of drug and non-drug users (N = 4723). The results of the comparison of the average values of the BFI-10 scales (t-test) show that there are statistically significant differences between young people who used and did not use drugs in the 12 months before the survey. …”
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Expression of Concern on “The Novel Oral Drug Subetta Exerts an Antidiabetic Effect in the Diabetic Goto-Kakizaki Rat: Comparison with Rosiglitazone” by Journal of Diabetes Research

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Correlation Analysis Between Multi-Drug Resistance Phenotype and Virulence Factor Expression of Clinical <i>Pseudomonas aeruginosa</i> by Wenli Xu, Runcheng Zhou, Jingwei Pan, Zhuangcong Liu, Xuyu Huang, Yueqiao Lin, Nan Li, Kecan Chen, Wenbo Sun, Yi Deng, Anping Yang, Xin Chen

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Using Large Language Models to Detect and Understand Drug Discontinuation Events in Web-Based Forums: Development and Validation Study by William Trevena, Xiang Zhong, Michelle Alvarado, Alexander Semenov, Alp Oktay, Devin Devlin, Aarya Yogesh Gohil, Sai Harsha Chittimouju

“…However, the detection of drug discontinuation events (DDEs) remains underexplored. …”
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Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system by Felicijan Tjaša, Bogataj Marija

“…Further, the effect of GE on the dissolution of model drugs from immediate-release tablets was assessed by determining the amount of dissolved drug in the samples pumped out of the stomach compartment. …”
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Examining the Influence of Alexithymia, Gender, and Age on Drug Use among Iranian Students: the Mediating Role of Emotion Regulation Difficulties by Mohamad Hatami Nejad, Masoud Sadeghi, Esmaeil Sadri Damirchi, Mohammadreza Noroozi Homayoon

Subjects: “…Drug use…”
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AI-driven prediction of drug activity against Toxoplasma gondii: Data augmentation and deep neural networks for limited datasets by Natalia V. Karimova, Ravithree D. Senanayake

“…Finally, the model was applied to screen FDA-approved drugs after filtering out molecules that did not align with the characteristics of the training dataset. …”
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Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury by Akemi Tsutsui, Yasuni Nakanuma, Kouichi Takaguchi, Satoko Nakamura, Hiroshi Shibata, Nobuyuki Baba, Tomonori Senoh, Takuya Nagano, Hiroko Ikeda

“…The liver biopsy remains a valuable tool in the diagnosis of drug-induced liver injury (DILI). The Digestive Disease Week Japan 2004 (DDW-J) scale proposed as an objective tool for the diagnosis of DILI has been widely used in Japan. …”
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Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

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Antimicrobial Activity of <i>Zingiber Officinale</i> and <i>Allium Sativum</i> on some Drug Resistant Bacterial Isolates by S.E. Emmanuel, E.O. Ehinmitan, R.S. Bodunde, J.C. Joseph

“… Ginger and garlic are very important and useful spices and are used as therapeutic agent against many pathological infections. Increasing multi-drug resistance of pathogens forces researchers to find alternative compounds for treatment of infectious diseases. …”
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Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) by Shumyila Nasir, Muhammad Sufyan Vohra, Danish Gul, Umm E Swaiba, Maira Aleem, Khalid Mehmood, Saadia Andleeb

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Lipid-based systems with precipitation inhibitors as formulation approach to improve the drug bioavailability and/or lower its dose: a review by Kovačević Mila, Gašperlin Mirjana, Pobirk Alenka Zvonar

“…Lipid-based systems, such as self-microemulsifying systems (SMEDDS) are attracting strong attention as a formulation approach to improve the bioavailability of poorly water-soluble drugs. By applying the “spring and parachute” strategy in designing supersaturable SMEDDS, it is possible to maintain the drug in the supersaturated state long enough to allow absorption of the complete dose, thus improving the drug’s bio-availability. …”
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Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist by Mahantesh Namdev Jadhav, Ganesh Rajendra Kokil, Shilpa Sudhakar Harak, Sanjay Baburao Wagh

“…Given the therapeutic and toxic limitations of clinically available drugs, it is clear that there is still a need for the development of new generation antipsychotic agents with an improved clinical profile. …”
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Targeting TCMR-associated cytokine genes for drug screening identifies PPARγ agonists as novel immunomodulatory agents in transplantation by Lu Hu, Lu Hu, Xiaohan Zhang, Xiaohan Zhang, Weiqi Zhang, Weiqi Zhang, Shuai Jin, Shuai Jin, Jie Zhao, Jianming Zheng, Wenli Song, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen

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Analysis of Protein-Ligand Interactions of SARS-CoV-2 Against Selective Drug Using Deep Neural Networks by Natarajan Yuvaraj, Kannan Srihari, Selvaraj Chandragandhi, Rajan Arshath Raja, Gaurav Dhiman, Amandeep Kaur

“…The DNN senses the response of protein-ligand interactions for a specific drug and identifies which drug makes the interaction that combats effectively the virus. …”
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Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy by K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev

“…This opens up the prospect of using SCID mice as an animal model for smallpox to develop antiviral drugs intended for people with severe immuno­suppressive states.…”
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A Real-World, Multicenter Assessment of Drugs Requiring Weight-Based Calculations in Overweight, Adult Critically Ill Patients by Sandra L. Kane-Gill, Nicholas P. Wytiaz, Lisa M. Thompson, Karina Muzykovsky, Mitchell S. Buckley, Henry Cohen, Amy L. Seybert

“…Prescribing appropriate doses of drugs requiring weight-based dosing is challenging in overweight patients due to a lack of data. …”
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The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases by Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman

“…The Pah1-CC (catalytic core) variant, which lacks regulatory sequences, was inhibited by both drugs in accordance with molecular docking data. …”
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Use of failure mode and effect analysis to improve the monoclonal antibody drugs management process in pharmacy intravenous admixture services by Jian Cai, Min-Xian Li, Shuai Lu, Dan Shen, Wei Xie, Jian-Jun Zhu, Guo-Jun Jiang, Chun-Xiao Lu

“…Through refinement, we successfully mitigated the occurrence of high-risk failure modes of mAb drugs in PIVAS. These efforts are aimed at enhancing the safety and efficacy of mAb drugs, ultimately ensuring patient safety.…”
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South African Rheumatism and Arthritis Association 2024 guidelines for the use of biologic and targeted synthetic disease-modifying antirheumatic drugs by E van Duuren, J Potts, U Brijlal, S Botha, S Didi, K Makan, M van Dam, K Chinniah, B Hodkinson

“… Biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) target a specific pathway of the immune system, and are usually prescribed after failure of conventional synthetic disease-modifying antirheumatic drug therapy. …”
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