Incidence and Predictors of Outcome in the Treatment of In-Stent Restenosis with Drug-Eluting Balloons, a Real-Life Single-Centre Study by Kyle Murnaghan, Helen Bishop, Navjot Sandila, Bakhtiar Kidwai, Lawrence Title, Ata Ur Rehman Quraishi, Catherine Kells, Hussein Beydoun, Osama Elkhateeb

“…To determine the one-year and five-year occurrence and prognosticators of major adverse cardiac events (MACE: composition of all-cause death, myocardial infarction, target vessel revascularization, and vessel thrombosis), mortality, and target lesion revascularization (TLR) in patients with in-stent restenosis (ISR) treated with drug-eluting balloons (DEBs). Background. DEBs have become an emerging therapeutic option for ISR. …”
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Enhancing transdermal drug delivery: formulation and evaluation of simvastatin-loaded invasomes in carbopol gel for improved permeability and prolonged release by Deepak Kumar Dash, Dibya Sundar Panda, Satyanarayan Pattnaik, Riya Vaiswade, Gayatri Gupta

“…Upon evaluating these parameters, our findings suggest that the simvastatin invasomal gel effectively enhances drug permeability across membranes and successfully achieves prolonged drug release.…”
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Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS by Wang Jinglong, Fan Liqun, Zhang Lihua, Zheng Dandan, Wang Yingzi, Sun Xiao, Ji Yonghui

“…To evaluate the bioavailability of ellagic acid loaded super-saturatable self-microemulsifying drug delivery system (S-SMEDDS), its pharmacokinetic properties were studied in rats with an ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. …”
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Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release by Chiara De Soricellis, Chiara Amante, Paola Russo, Rita Patrizia Aquino, Pasquale Del Gaudio

“…In vitro studies revealed a faster release for lower drug loadings (90% release in 6 h) compared to sustained release over 7 days for higher-loaded nanoparticles, attributed to polymer degradation and drug-polymer interactions on the surface of the particles, as confirmed by FTIR analyses. …”
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HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis by Enhao Wang, Shazhou Li, Yang Li, Tao Zhou

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Clinical impact of 24-hour pH-metry in esophageal and stomach diseases diagnostics and pharmacological drugs efficacy testing by A. S. Trukhmanov, Olga A. Storonova, V. T. Ivashkin

“…Considerable diagnostic potential of pH-metry allow to verification of disease, individual estimation of the drug efficacy and treatment mode, control of response to carried out treatment, diagnostics of treatment resistance, detection of night «acid breakthrough» episodes and duodenogastric refluxes. …”
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Recent progress in pharmaceutical excipients as P-glycoprotein inhibitors for potential improvement of oral drug bioavailability: A comprehensive overview by Fitrianti Darusman, Taofik Rusdiana, Iyan Sopyan, Hanifa Rahma, Millati Hanifa

“…Pharmaceutical excipients such as P-glycoprotein inhibitors can also increase the solubility and affinity of drugs to the intestinal membrane, enhance paracellular pathways and endocyte uptake, and activate lymph transport pathways, thereby increasing the bioavailability of oral drugs. …”
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An Injectable Hydrogel Bioimplant Loaded with Engineered Exosomes and Triple Anti-Tuberculosis Drugs with Potential for Treating Bone and Joint Tuberculosis by Huang J, Li H, Mei Y, Yi P, Ren Y, Wang Y, Han L, Tang Q, Liu D, Chen W, An Y, Hu C

Subjects: “…triple anti-tuberculosis drugs loaded…”
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Age Differences in Long Term Outcomes of Coronary Patients Treated with Drug Eluting Stents at a Tertiary Medical Center by Nicolas W. Shammas, Gail A. Shammas, Peter Sharis, Michael Jerin

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Application of Eudragit RS 30D as a Potential Drug Release Retardant of Acetaminophen and Caffeine for Prolonged Duration of Comfort by Lailoona Jaweed, Huma Dilshad, Ghulam Sarwar

“…Considering the fact that there is no such formulation available in the pharmaceutical market, it is expected that this drug could be an effective introduction. Hydrophobic polymers have a great application in pharmaceutical sciences as they retard the release of water-soluble drugs and give prolonged effect. …”
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Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques by Hezha Abdullah Ali, Hunar Kamal Omer

“…The solid dispersion powders underwent evaluation for their percentage drug content, percentage yield, solubility, dissolution test, XRD, DSC, SEM, and FTIR. …”
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Prevalence of Multiple Drug-Resistant Bacteria in the Main Campus Wastewater Treatment Plant of Wolaita Sodo University, Southern Ethiopia by Chimdesa Adugna, Krishna Moorthy Sivalingam

“…Wastewater treatment plants (WWTPs) are important reservoirs for the development of drug resistance and a potential route for the dissemination of antibiotic resistance genes (ARGs) in the environment. …”
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Aggregation‐based dual‐target probe for dual‐colour super‐resolution monitoring mitophagy and evaluating drugs regulating mitochondria by Xiu‐Zhi Yang, Hongbao Fang, Shumeng Li, Chengyan Chu, Yunhua Zhang, Ying Yang, Weijiang He, Yuncong Chen, Zijian Guo

Subjects: “…drug evaluation…”
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Graph Energy Variants and Topological Indices in Platinum Anticancer Drug Design: Mathematical Insights and Computational Analysis with DFT and QTAIM by Suha Wazzan, Nurten Urlu Ozalan

“…Overall, this study presents an innovative approach that bridges graph energies, topological indices, and DFT with the properties (physical and chemical) of platinum anticancer drugs, offering insights into their molecular properties and potential for enhanced drug design.…”
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Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride by Amr M. Mahmoud, Nariman A. El-Ragehy, Maha A. Hegazy, Samia A. Tawfik, Ghada A. Sedik

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A HER2 Specific Nanobody–Drug Conjugate: Site-Selective Bioconjugation and In Vitro Evaluation in Breast Cancer Models by Anders H. Hansen, Kasper I. H. Andersen, Li Xin, Oliver Krigslund, Niels Behrendt, Lars H. Engelholm, Claus H. Bang-Bertelsen, Sanne Schoffelen, Katrine Qvortrup

“…Subsequent site-selective acylation on the C-terminally activated lysine residue allowed installation of the cytotoxin monomethyl auristatin E-functionalized cathepsin B-sensitive payload to provide a highly homogenous nanobody–drug conjugate (NBC), which demonstrated high potency and selectivity for HER2-positive breast cancer models.…”
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In-silico tool based on Boolean networks and meshless simulations for prediction of reaction and transport mechanisms in the systemic administration of chemotherapeutic drugs. by Fabián Mauricio Vélez Salazar, Iván David Patiño

“…Subsequently, a Boolean model is developed to determine the presence, interaction and rates of RTMs based on the comparison of the spatio-temporal evolution of the drug concentration ratios, being this the main contribution of the present work to the comprehension of the phenomena involved in the systemic administration of chemotherapeutic drugs in cancer tumors. …”
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Low Resolution Limits and Inaccurate Algorithms Decrease Significantly the Value of Late Loss in Current Drug-Eluting Stent Trials by Johannes B. Dahm, Frank van Buuren

“…Smaller late loss differences are usually not greater than the inherited resolution limits of QCA, which is especially the case in small differences between the various stents in the drug-eluting stent era. Late loss include additional systematic and random errors, due to the fact that measurements were taken at two different time points including the inherited resolution and calibration limits of QCA on two occasions. …”
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Motion – Cyclo-oxygenase-2 Selective Nonsteroidal Anti-Inflammatory Drugs are as Safe as Placebo for the Stomach: Arguments Against the Motion by Andreas Maetzel

“…Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both isoenzymes, resulting in damage to the mucosa of the stomach and duodenum, but also in cardioprotection. …”
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Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report by Nobuki Shioya, Shigehiro Shibata, Masahiro Kojika, Shigeatsu Endo

“…The present case highlights the need for exercising caution while prescribing slow-release nonsteroidal anti-inflammatory drugs with corticosteroids to patients with autoimmune diseases, as such treatment may exacerbate intestinal epithelial abnormalities.…”
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