Role of neuroimmunomodulation by vagus nerve stimulation in rheumatoid arthritis: Are we heading towards a drug-free era? by Prasan Deep Rath, Swetal Pandey, Rahul Bisaralli

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AxiWorm: a new tool using YOLOv5 to test antiparasitic drugs against Trichinella spiralis by Javier Sánchez-Montejo, Miguel Marín, María Alejandra Villamizar-Monsalve, María del Carmen Vieira, Belén Vicente, Rafael Peláez, Julio López-Abán, Antonio Muro

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Persistent hepatocyte secretory failure in lopinavir/ritonavir related to drug-induced liver injury: a case report by Yue Sun, Ran Wang, Cai'e Wang, Xiaodong Shao, Xiaojie Zheng, Hui Li, Yingkai Chi, Baocheng Deng, Yiling Li, Shenghao Jin, Xingshun Qi

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Estimating the Ground and Excited State Dipole Moments of Levofloxacin and Norfloxacin Drugs Using Solvatochromic Effects and Computational Work by Kinfe Woldegiorges, Abebe Belay, Alemu Kebede, Tamirat Abebe

“…In this research, the ground and excited state dipole moments of LVF and NRF drugs were estimated using solvatochromic effects and computational work. …”
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Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach by Shabir Ahmad Ganai, Suma Mohan, Shahid Ahmad Padder

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Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…Conventional therapeutics for RA, including disease‐modifying antirheumatic drugs (DMARDs), nonsteroidal anti‐inflammatory drugs (NSAIDs), and corticosteroids, frequently result in unintended adverse effects. …”
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Long-term outcome in people who use drugs successfully treated for hepatitis C infection with glecaprevir/pibrentasvir by Shana Yi, David Truong, Brian Conway

“…Background: Several clinical trials, including the recently published the GRAND PLAN study from Vancouver Infectious Diseases Center (VIDC), have demonstrated the efficacy of hepatitis C (HCV) therapy among active drug users, including those facing significant addiction-related and social challenges. …”
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High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms by Abd El-Hay Soad S., Hashem Hisham, Gouda Ayman A.

“…Calibration curves were rectilinear over the range of 0.195–100 μg mL−1 for all the drugs studied. Recovery values were 99.9, 99.6 and 99.0 % for XIP, TRI and HCT, respectively. …”
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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

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Disproportionate, differential and targeted treatment: people who use drugs’ experiences of policing during the COVID-19 pandemic by Shelley Walker, Kasun Rathnayake, Paul Dietze, Peter Higgs, Bernadette Ward, Margaret Hellard, Joseph Doyle, Mark Stoove, Lisa Maher

Subjects: “…Drug use…”
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Intestinal schistosomiasis in remote areas of Southwest Ethiopia, a target region for large-scale mass drug administration by Yared Nigusu, Teshome Bekana, Eshetu Chilo, Sisay Teferi, Dereje Oljira Donacho, Dereje Gemeda, Tefera Darge, Abeza Mitiku, Abdi Geda Gedefa, Tadesse Sime, Wubishet Gezimu, Oda Gizaw, Gemechu Tadila, Miressa Bekana, Berhanu Erko

“…Strategies to end the disease as a public health threat, mainly in remote and endemic areas, should consider novel integrated strategies targeting the life cycle of schistosomes besides the large-scale mass drug administration.…”
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Monte Carlo simulation methods-based models for analyzing the kinetics of drug delivery from controlled release systems by Saúl Jiménez-Jiménez, Salomón Cordero-Sánchez, José-Gerardo Mejía-Hernández, David Quintanar-Guerrero, Luz-María Melgoza-Contreras, Rafael Villalobos-García

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Mindfulness-based relapse prevention for drug addiction in Nepal: impact and implications of an initial 2-day training of trainers by Arun Jha, Bharat Goit, Robin Jha, Prerna Jha, Prabhat Kiran Pradhan, Achyut Acharya

“…Drug addiction is rife in Nepal, with a high relapse rate following treatment. …”
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The Prevalence and Incidence of Sexually Transmitted Infections in a Prospective Cohort of Injection Drug Users in Vancouver, British Columbia by Laura M Kuyper, Courtney LC Collins, Thomas Kerr, Robert S Hogg, Kathy Li, Mark W Tyndall, Julio SG Montaner, Evan Wood

“…BACKGROUND: While several studies have reported on sexual risk behaviours and the prevalence of sexually transmitted infections (STIs) among injection drug users (IDUs), there are fewer prospective studies that have been able to examine populations of IDUs with no history of STIs. …”
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Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“… Purpose: This review aims to evaluate the chemo preventive and therapeutic potential of non-steroidal anti-inflammatory drugs (NSAIDs) in cancer management, emphasizing their mechanisms of action and clinical relevance. …”
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Evaluation of Risk Factors Causing Diagnostic Delay in Non-steroidal Anti-inflammatory Drug-exacerbated Respiratory Disease by Melek Cihanbeylerden, Hazal Kayıkçı, Çise Tüccar, Ebru Damadoğlu, Gül Karakaya, Ali Fuat Kalyoncu

Subjects: “…non-steroidal anti-inflammatory drug-exacerbated respiratory disease…”
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Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus by Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim

“…Abstract Background The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. …”
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Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels by Rasgado Lourdes A. Vega, Villanueva Iván, Díaz Fernando Vega

“…The results support the role of DA and NA in regulating seizure activity in the brain and indicate that EFBL offers a potential treatment for refractory epilepsy without complementary drugs and Parkinson’s disease, without the drawbacks of oral therapies.…”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Conclusions xiRB49-MMAE is a promising drug candidate for clinical trials in ETB + tumors. …”
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Benzyl Benzoate 25% Versus Permethrin 5% for Scabies. Are Topical Drugs Still Required in the Oral Ivermectin Era? by Vittorio Tancredi, Gaetano Licata, Luca Damiani, Pierfrancesco Benvenuto, Giuseppe Argenziano, Caterina Mariarosaria Giorgio

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