A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy by Kelli Scott, Michael J. Mello, Geraldine Almonte, Emely Arenas Lemus, Julie R. Bromberg, Janette Baird, Anthony Spirito, Mark R. Zonfrillo, Karla Lawson, Lois K. Lee, Emily Christison-Lagay, Stephanie Ruest, Jeremy Aidlen, Andrew Kiragu, Charles Pruitt, Isam Nasr, Robert Todd Maxson, Beth Ebel, Sara J. Becker

“…Abstract Background Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based practice that can identify adolescents who use alcohol and other drugs and support proper referral to treatment. Despite an American College of Surgeons mandate to deliver SBIRT in pediatric trauma care, trauma centers throughout the United States have faced numerous patient, provider, and organizational level barriers to SBIRT implementation. …”
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Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…Conclusions Although characterized as immunosuppressive drugs, PIs improved RV delivery to MM cells but also enhanced anti-MM efficacy through immune-mediated killing of myeloma cells, independently of their PI sensitivity. …”
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Antimicrobial Profiling of Bacteria Isolated from Fish Sold at Informal Market in Mufakose, Zimbabwe by Claudious Gufe, Tinashe Canaan Hodobo, Bernard Mbonjani, Otlia Majonga, Jerikias Marumure, Shuvai Musari, Gilbert Jongi, Pious Vengesayi Makaya, Jairus Machakwa

“…All the isolates were multidrug-resistant (resistant to at 3 or more drugs tested) except Proteus mirabilis. Proteus mirabilis has multiple antibiotic resistance (MAR) index of 0.2, and the other isolated bacteria had MAR indexes greater than 0.2 ranging from 0.3 to 0.7. …”
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Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo by Bayaki Saka, Abla Séfako Akakpo, Julienne Noude Teclessou, Garba Mahamadou, Abas Mouhari-Toure, Kossi Dzidzinyo, Adam Nouhou Diori, Nidain Maneh, Sabin Prince-Agbodjan, Koussake Kombaté, Komi Balo, Kissem Tchangai-Walla, Palokinam Pitché

“…There were 113 women and 64 men, with an average age of 31.7±13.0 years (range: 5 to 80 years). The most used drugs were antibacterial sulfonamides (35.6%) and nevirapine (24.3%). …”
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Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [ver... by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

“…This increased burden demands new targeted therapies with novel compounds either synthetically produced or derived from indigenous plants, which could be a promising approach for the development of drugs. Euphorbia thymifolia L is a widely growing tropical herb that has been reported to have various ethnopharmacological properties. …”
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Seroprevalence of Human Herpesvirus Infections in Newly Diagnosed HIV-Infected Key Populations in Dar es Salaam, Tanzania by Doreen Kamori, Agricola Joachim, Mucho Mizinduko, Godfrey Barabona, Macdonald Mahiti, Upendo Kibwana, Mtebe Majigo, Salim Masoud, Ambele M. Mwandigha, Takamasa Ueno, Elia Mmbaga, Eligius Lyamuya

“…In the population at high risk of HIV infection, also termed as key populations (female sex workers (FSW), men who have sex with men (MSM), and people who inject drugs (PWID)), and their sexual partners, HHV infections can potentially compromise the efforts to prevent and control HIV infection. …”
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Circulating Baseline CXCR3+Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis by Julia M. Scheffler, Christina Drevinge, Catharina Lindholm, Inger Gjertsson, Kristina Lend, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Tuulikki Sokka‐Isler, Dan Nordström, Kim Hørslev‐Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Ronald vanVollenhoven, Hans Carlsten, Mattias Lorentzon, Anna‐Karin Hultgård Ekwall, Anna Rudin, Ulrika Islander

“…The aim of this study was to evaluate relations between circulating monocytes, T cell subsets, and changes in bone characteristics before and after treatment with biological disease‐modifying antirheumatic drugs (bDMARDs) in RA. Methods Thirty patients with untreated early RA who met the American College of Rheumatology/EULAR 2010 criteria were included. …”
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Prevalence and determinants of intimate partner violence in pregnancy: a multicentre, binational study by Akaninyene E. Ubom, Chidinma P. Ohachenu, Suraiya S. Auwal, Safiyya F. Usman, Akwasi B. Opoku, Caesar A. Ansing, Jamiu S. Shehu, Peter C. Oriji, Komommo O. Okpebri, Ademola S. Olutoye, Rasheedat O. Balogun, Joshua E. Ifebude, Oluwole D. Obadina, Solomon Nyeche, Abdurrahman A. Bunawa, Ukeje J. Ifeanyi, Fatima A. Mahmud, Hauwa S. Gumbi, Akeem O. Ojugbele, Olubusayo O. Areo, Olakunle E. Ogunjide, Mariam M. Shiru, Ada C. Okpighe, Chia Iornengen, David M. Aqua, Suleiman Z. Abubakar, Fadekemi O. Gabriel-Raji, Oyiana I. Gregory, Lukman O. Lawal, Mathias Abude, David Walawah, Aderopo I. Adelola, Akpofure H. Ese, Jane C. Orijani, Ephraim A. Suobite, Olire C. Afon, Obinna P. Ekwebalam, Baderinwa O. Akanji, Emmanuel E. John, Ibraheem O. Awowole, Omotade A. Ijarotimi, Ngozi Thompson, John I. Ikimalo, Olusola B. Fasubaa

“…Predictors of IPV included the women’s marital status (p = 0.001), educational status (p = 0.040), rural residence (p = 0.034), occupation (p = 0.040), spouse’s/partner’s occupation (p = 0.021), use of illicit drugs by spouse/partner (p = 0.014), history of psychiatric illness in spouse/partner (p = 0.030), experience of IPV in previous relationship(s) by spouse/partner (p = 0.011), and witness of parental IPV by spouse/partner (p < 0.001). …”
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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…Limited by laboratory culture, no vaccines or drugs have been developed against HuNoVs. Here, we screened nucleic acid aptamers against the widespread HuNoV GII.4 and emerging HuNoV GII.17.Methods: After ten rounds of sieving for HuNoV GII.4 and GII.17 virus-like particles (VLPs), eight ssDNA aptamers were generated and characterized for each genotype.Results: Four of the eight aptamers generated for GII.4 VLP had dissociation constants (Kd) less than 100 nM, and all aptamers for GII.17 VLP had Kd less than 10 nM. …”
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Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…Despite the availability of various targeted drugs for RA, these treatments are limited by adverse reactions, warranting new treatment approaches. …”
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Sex differences in intracranial plaque burden in patients with type 2 diabetes mellitus with acute ischemic cerebrovascular disease: a pilot study based on high-resolution MRI by Xuejiao Yan, Ling Li, Jie Gao, Lihui Wang, Kai Ai, Xiaoyan Lei, Min Tang, Xiaoling Zhang, Dongsheng Zhang

“…Patients with a history of T2DM and currently taking hypoglycemic drugs were defined as being treated. Poisson regression models or negative binomial regression models were used to analyze the interaction between sex and treatment in relation to plaque burden.ResultsA total of 495 plaques were detected in 120 patients (75 male; mean age, 60.77 ± 11.01 years), including 311 proximal and 184 distal plaques. …”
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Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis by Jéssica Adriana de Jesus, Márcia Dalastra Laurenti, Leila Antonangelo, Caroline Silvério Faria, João Henrique Ghilardi Lago, Luiz Felipe Domingues Passero

“…Leishmaniasis is a neglected tropical disease caused by the flagellated protozoa of the genus Leishmania that affects millions of people around the world. Drugs employed in the treatment of leishmaniasis have limited efficacy and induce local and systemic side effects to the patients. …”
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CDK14 regulates the development and repair of lung by Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen

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Corticosteroid use beyond 1-year post heart transplantation is associated with worse outcomes: A contemporary analysis of the ISHLT registry by Abhishek Jaiswal, MD, William L. Baker, Pharm.D, Ashwin Pillai, MD, Michelle Kittleson, MD, PhD, Balaphanidhar Mogga, MD, Zeina Jedeon, MD, Caroline Chen, David A. Baran, MD

“…Introduction: Immunosuppressive drugs ensure graft survival in heart transplantation (HT). …”
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The formation pathway of flavor compounds in steamed Antarctic krill (Euphausia superba) based on untargeted metabolomics by Tingting Yang, Yang Liu, Jing Bai, Yan Fan, Ye Chen, Ping Dong, Xia Yang, Hu Hou

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Risk factors and consequences of traumatic brain injury in a Swiss male population cohort by Jean-Bernard Daeppen, Gerhard Gmel, Joseph Studer, Valentin Petre Matei, Alina Elena Rosca, Alexandru Neculai Pavel, Radu Mihai Paun

“…Risk factors were measured at baseline (2010–2012) and at follow-up 1 (FU1; 2012–2014), while the consequences and TBI were measured at follow-up 2 (FU2; 2016–2018).Setting Switzerland.Participants All participants at FU2 (Mage=25.43, SD=1.25) of the Cohort Study on Substance Use Risk Factors (N=4881 young Swiss men after listwise deletion).Measures The outcomes measured were TBI, SUD (ie, alcohol, nicotine, cannabis, other illicit drugs), depression and personality traits (ie, sensation seeking, anxiety-neuroticism, sociability, aggression-hostility) at FU2. …”
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Novel Thiosemicarbazone Derivatives from Furan-2-Carbaldehyde: Synthesis, Characterization, Crystal Structures, and Antibacterial, Antifungal, Antioxidant, and Antitumor Activities by Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Maik Icker, Harald Krautscheid, Lothar Beyer, Carmen Tamariz-Angeles, Percy Olivera-Gonzales

“…Compound 5 exhibited significant antibacterial activity against Staphylococcus aureus ATCC700699 (MIC = 1 μg/mL) compared to the nitrofurantoin and gentamicin reference drugs (MIC = 1–25 and 10->100 μg/mL, respectively). …”
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The Effects of Statin Dose, Lipophilicity, and Combination of Statins plus Ezetimibe on Circulating Oxidized Low-Density Lipoprotein Levels: A Systematic Review and Meta-Analysis o... by Tannaz Jamialahmadi, Fatemeh Baratzadeh, Željko Reiner, Luis E. Simental-Mendía, Suowen Xu, Andrey V. Susekov, Raul D. Santos, Amirhossein Sahebkar

“…Elevated plasma low-density lipoprotein cholesterol (LDL-C) is the main risk factor for atherosclerotic cardiovascular disease (ASCVD). Statins are the drugs of choice for decreasing LDL-C and are used for the prevention and management of ASCVD. …”
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Risk factors for thromboembolic and bleeding events in anticoagulated patients with atrial fibrillation: the prospective, multicentre observational PREvention oF thromboembolic eve... by Raffaele De Caterina, Kurt Huber, Richard Schilling, Miklos Rohla, Thomas W Weiss, Ladislav Pecen, Giuseppe Patti, Jolanta M Siller-Matula, Renate B Schnabel, Dipak Kotecha, Markus Lucerna, Paulus Kirchhof

“…The incidence of thromboembolic and major bleeding events was 2.34% (95% CI 1.93% to 2.74%) and 2.84% (95% CI 2.41% to 3.33%) after 1-year of follow-up, respectively.Abnormal liver function, prior stroke or transient ischaemic attack, labile international normalised ratio (INR), concomitant therapy with antiplatelet or non-steroidal anti-inflammatory drugs, heart failure and older age (≥75 years) were independently associated with both thromboembolic and major bleeding events.With the exception of unstable INR values, these risk factors were validated in patients treated with NOACs (PREFER in AF Prolongation Study, 72±9 years, 40% female, CHA2DS2-VASc 3.3±1.6). …”
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