Efficacy and Tolerance of Vascular Electrical Stimulation Therapy in the Management of Vaso-Occlusive Crises in Patients with Sickle Cell Disease: A Phase II Single-Centre Randomiz... by Renée-Paule Botti, Sie Saïda Bokoum, Etienne L’Hermite, Dohoma Alexis Silue, Boidy Kouakou, Sarah Anastasie Bognini, Serge Arnaud Agoua, Edgar Mandeng Ma Linwa, Roméo Ayemou, Kouassi Gustave Koffi

“…Treatment mainly consists of intravenous morphine or nonsteroidal anti-inflammatory drugs (NSAIDs), which have many dose-related side effects. …”
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RNA sequence analysis landscape: A comprehensive review of task types, databases, datasets, word embedding methods, and language models by Muhammad Nabeel Asim, Muhammad Ali Ibrahim, Tayyaba Asif, Andreas Dengel

“…Furthermore, researchers are harnessing RNA's therapeutic potential for transforming traditional treatment paradigms into personalized therapies through the development of RNA-based drugs and gene therapies. To gain insights of biological functions and to detect diseases at early stages and develop potent therapeutics, researchers are performing diverse types RNA sequence analysis tasks. …”
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Effect of primary tumor volume on survival of concurrent chemoradiotherapy in stage IV non‐small cell lung cancer by Xiaxia Chen, Wei Zhang, Lan Luo, Shimei Fu, Dongdong Cao, Shengfa Su, Qingsong Li, Wengang Yang, Yichao Geng, Bing Lu, Weiwei Ouyang

“…Chemotherapy was a platinum‐based combined regimen of two drugs. The number of median chemotherapy cycles was 4 (2–6), and the cut‐off value of the planning target volume (PTV) dose of the primary tumor was 63 Gy (30–76.5 Gy). …”
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The modern options of chronic hepatitis C antiviral therapy with daclatasvir: results of named patient program by V. T. Ivashkin, M. V. Mayevskaya, D. T. Abdurakhmanov, I. G. Bakulin, N. I. Geyvandova, M. L. Zubkin, S. N. Kizhlo, A. V. Kuznetsova, I. B. Latysheva, N. A. Mamonova, V. G. Morozov, O. I. Sagalova, Ye. V. Esaulenko, Ye. O. Lyusina

“…Approval of Ministry of Healthcare of the Russian Federation to import of drugs was received for the treatment of 101 HCV-infected patients with compensated LC, who, been untreated had an urgent need for effective therapy, with estimated life expectancy less than 12 months, in 12 centers of the Russian Federation. …”
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A descriptive study of blood pressure in people with self-reported substance use seeking health care in region F, Johannesburg, South Africa by K.E. Oladimeji, S. Gumede, A. Nyatela, S. Nonyukela, R. Mohale, S.T. Lalla-Edward, D. Dwarka

“…Substance use such as alcohol, tobacco and drugs, is one of various factors attributable to elevated blood pressure This study describes the prevalence of elevated blood pressure and associated factors among individuals who self-reported to substance use. …”
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Access to HIV testing and factors associated among sexual minority women in a metropolitan region of the Brazilian Amazon by Janaína de Freitas Vale, Wanderson Santiago de Azevedo Júnior, Paula Regina Barbosa de Almeida, Adinaldo Moreira Martins, Flavine Evangelista Gonçalves, Eliã Pinheiro Botelho, Fabianne de Jesus Dias de Sousa, Cintia Yolette Urbano Pauxis Aben-Athar, Luiz Fernando Almeida Machado, Glenda Roberta Oliveira Naiff Ferreira

“…While the lowest chances of never having tested for HIV were among participants who used drugs OR 0.44; p = 0.008) and women who had already had an STI (OR 0.20; p = 0.044). …”
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Childhood-Onset Takayasu Arteritis: Clinical Features of Disease and Relapse Risk Factors by Vera Podzolkova, Galina Lyskina, Olga Shpitonkova, Angelina Polyanskaya, Svetlana Chebysheva, Marina Shakhnazarova, Jinbo Zhao, Aleksandr Suvorov, Vera Khudoroshkova, Natalia Geppe

“…Despite aggressive treatment with glucocorticoids (GCs) and non-biological disease-modifying antirheumatic drugs (nbDMARDs), about 30% of patients experience resistance to therapy or relapse. …”
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A comparative study of analgesic effect between ultrasound-guided posterior vis-a-vis lateral transversus abdominis plane block in patients undergoing total abdominal hysterectomy... by Rajib Sikder, Sankar Roy, Arunava Biswas, Dipasri Bhattacharya

“…Ultrasound-guided blocks help in the correct localization of the plane and proper deposition of drugs. Aims and Objectives: This study was done to compare the analgesic effect of posterior TAP block and lateral TAP block in TAH+BSO. …”
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Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey by Chen Zhao, Liang Tang, Ting Chen, Hui Yang, Xiong Chen, Xiaobo Cui, Li Shi, Xiangping Li, Jian He, Xiaoxia Peng, Shuifang Xiao, Jinrang Li, Hongliang Zheng, Junbo Zhang, Shuihong Zhou, Donghui Chen, Xuping Xiao, Hui Huangfu, Zhenfeng Tao, Yehai Liu, Shenhong Qu, Guangke Wang, Linli Tian, Wensheng Zhou, Hongyan Fang, Yongwang Huang, Guodong Yu, Zhenqun Lin, Ruixia Ma, Zhaoyan Yu

“…As many as 73.1% of all participants knew that proton pump inhibitors were the first-line treatment drugs. An analysis of the overall status of awareness using a scoring system suggested that otolaryngologists were better aware owing to more access, working at 3A hospitals, and postgraduate or above educational background (all p<0.05).Conclusion Although the majority of Chinese otolaryngologists had heard of LPRD, their overall awareness about the disease was not encouraging. …”
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Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective... by Yukitaka Ueki, Tom W J Huizinga, René E M Toes, Shoichi Fukui, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami, Tomohiro Koga, Naoki Matsuoka, Toshihiko Hidaka, Naoki Iwamoto, Mami Tamai, Shin-ya Kawashiri, Akitomo Okada, Ayako Nishino, Tamami Yoshitama, Takahisa Suzuki, Toshimasa Shimizu, Shimpei Morimoto, Tomomi Tsuru, Karin A J van Schie, Masahiro Ayano, Remi Sumiyoshi, Yushiro Endo, Tohru Michitsuji, Kaori Furukawa, Masataka Umeda, Nobutaka Eiraku, Hiroaki Hamada

“…Objectives To evaluate the potential of clinical factors, ultrasound findings, serum autoantibodies, and serum cytokine and chemokine profiles as predictors of clinical outcomes in rheumatoid arthritis (RA).Patients and methods We included 200 patients with RA treated with biological and targeted synthetic disease-modifying antirheumatic drugs in a prospective multicentre ultrasound cohort study. …”
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Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…These findings position 45G3 as a promising candidate for EMCV management and provide a strong foundation for the future development of antiviral drugs targeting this widespread virus.…”
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Study of the Phytochemical Composition, the Antioxidant and the Anti-Inflammatory Effects of Two Sub-Saharan Plants: Piliostigma reticulatum and Piliostigma thonningii by K. Boualam, B. Ndiaye, H. Harhar, M. Tabyaoui, N. Ayessou, K. Taghzouti

“…Therefore, their chemical compounds could have potential applications as antioxidant and anti-inflammatory drugs.…”
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Protective Effects of Phycobiliproteins from <i>Arthrospira maxima</i> (Spirulina) Against Cyclophosphamide-Induced Embryotoxicity and Genotoxicity in Pregnant CD1 Mice by Yuliana García-Martínez, Amparo Celene Razo-Estrada, Ricardo Pérez-Pastén-Borja, Candelaria Galván-Colorado, Germán Chamorro-Cevallos, José Jorge Chanona-Pérez, Oscar Alberto López-Canales, Hariz Islas-Flores, Salud Pérez-Gutiérrez, Joaquín Cordero-Martínez, José Melesio Cristóbal-Luna

“…In this regard, the most used chemotherapy drugs to treat cancer are alkylating agents such as cyclophosphamide (Cp). …”
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Comparison of scores for predictability of corticosteroid failure in patients with acute severe ulcerative colitis by Knežević Milica A., Janjić Nebojša M., Lečić Vuk B., Todorović Nemanja B., Damjanov Dimitrije D.

“…Introduction: Methylprednisolone and hydrocortisone are the first-line drugs in the treatment of acute severe ulcerative colitis (ASUC). …”
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Effect of propofol and ciprofol in patients undergoing bronchoscopy: protocol for a double-blind, randomised controlled trial by Fang Chen, Cheng Li, Dongliang Li, Jinxuan Tang, Jiayu Huang

“…The secondary outcomes are the incidence of choking and injection pain, the type and dose of vasoactive drugs used during the operation, and the level of postoperative satisfaction among surgeons, anaesthesiologists and patients.Ethics and dissemination This trial was approved by the Medical Ethics Committee of Shanghai Fourth People’s Hospital, School of Medicine, Tongji University and registered with the Chinese Clinical Trials Registry (Identifier: ChiCTR2200063048) on 29 August 2022. …”
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Italian Expert Opinion on Chronic Hand Eczema: from Guidelines to Clinical Practice by Luca Stingeni, Maria Concetta Fargnoli, Fabrizio Guarneri, Anna Balato, Monica Corazza, Anna Belloni Fortina, Piergiacomo Calzavara Pinton, Antonio Costanzo, Silvia Mariel Ferrucci, Luigi Naldi, Giovanni Pellacani, Ketty Peris, Francesca Prignano, Giampiero Girolomoni

“…Treatment is often challenging because of limited approved drugs, and severe CHE is associated with reduced quality of life (QoL) and poor overall health measures in terms of psychological, functional, and occupational challenges. …”
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Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial by Gilberto Arias-Hernández, Cruz Vargas-De-León, Claudia C Calzada-Mendoza, María Esther Ocharan-Hernández

“…Patients were randomized into two groups: the experimental group (n = 21) received diltiazem (60 mg) and the control group (n = 21) received nifedipine (10 mg). Both drugs were orally administered every 8 hours. Systolic, diastolic, and mean blood pressures as well as the heart rate were recorded and analyzed (two-way repeated measures ANOVA) at baseline and after 6, 12, 18, 24, 30, 36, 42, and 48 hours. …”
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Frequency of Lower Lung Field Tuberculosis in Diabetes Mellitus Patients Attending Tertiary Care Hospital in Bangladesh: A Cross‐Sectional Study by Raihan Kamal Galib, Susanta Kumar Paul, Khujjista Akter, Manzurul Ibrahim Musa, Dip Jyoti Sarker, Shah Ashiqur Rahman Ashiq Choudhury, Shipan Chandra Paul, Rajashish Chakrabortty

“…PTB was diagnosed by positive sputum acid‐fast bacilli (AFB),/Culture,/Gene Xpert MTB/RIF, and DM, which was proven by taking oral hypoglycemic drugs or receiving insulin at the time of hospital admission. …”
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Effect of Combination Therapy of Canagliflozin Added to Teneligliptin Monotherapy in Japanese Subjects with Type 2 Diabetes Mellitus: A Retrospective Study by Yoshiro Fushimi, Atsushi Obata, Junpei Sanada, Yuichiro Iwamoto, Akiko Mashiko, Megumi Horiya, Akiko Mizoguchi-Tomita, Momoyo Nishioka, Yuki Kan, Tomoe Kinoshita, Seizo Okauchi, Hidenori Hirukawa, Kenji Kohara, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…In addition, combination drugs of both inhibitors have attracted much attention in aspects of its cost-effectiveness and improvement of patients’ adherence. …”
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Seasonal Variation in Antimicrobial Activity of Crude Extracts of Psammaplysilla sp. 1 from Phillips Reef, South Africa by Wasswa Cuthbert Kibungu, Justine Fri, Anna-Maria Clarke, Anthony Otigbu, Henry Akum Njom

“…Antifungal activity was observed by Psammaplysilla sp. 1 (30 mm) against C. albicans, and this was higher than that showed by standard drugs ICZ-10 µg (15 ± 0.1 mm), FLU-15 µg (21 ± 0.2 mm), and VCZ-5 µg (17 ± 0.1 mm), respectively. …”
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