Impaired mobility drives disability in psoriatic arthritis – An observational study from Karnataka Psoriatic Arthritis Cohort (KPsAC) by Vineeta Shobha, Chanakya Kodishala, S Chandrashekara, Sharath Kumar, Vikram Haridas, Vijay Rao, Ramesh Jois, Manisha Daware, Yogesh Preet Singh, Shweta Singhai, B G Dharmanad, Pramod Chebbi, R Subramanian, Ashwini Kamath, Uma Karjiigi, Vikramraj K Jain, Chethana Dharmapalaiah, Shiva Prasad, C Srinivas, J Ramya, Benzeeta Pinto, Beenish Nazir, Harshini, Mahendranath

“…I-HAQ was significantly lower in patients who had been on disease-modifying antirheumatic drugs for 6 months or more (P = 0.0001). Conclusions: The Indian version of HAQ-DI could be efficiently employed to assess outcomes in our cohort. …”
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Cost Effectiveness of Insulin Glargine versus Neutral Protamin Hagedorn Insulin in the Treatment of Type 2 Diabetes Patients in Turkey by Ilhan Satman, Hayley Bennett, Candeger Yilmaz, Sazi Imamoglu, Goksun Ayvaz, Abdurrahman Comlekci, Demet Ozkaya, Toros Sahin

“…Insulin treatment is necessary for patients failing to achieve glycaemic control with lifestyle modification or oral antidiabetic drugs. While neutral protamin Hagedorn (NPH) insulin has been traditionally prescribed for insulin introduction, insulin glargine has been shown to reduce glycated hemoglobin (HbA1c) with a more favourable hypoglycaemic profile. …”
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Intraoperative Analgesia with Magnesium Sulfate versus Remifentanil Guided by Plethysmographic Stress Index in Post-Bariatric Dermolipectomy: A Randomized Study by S. E. Silva Filho, S. Dainez, M. A. M. C. Gonzalez, F. Angelis, J. E. Vieira, C. S. Sandes

“…The evaluation of the antinociceptive potency of drugs and doses indirectly, through hemodynamic oscillations has been questioned. …”
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An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy by Maximilian Hammer, Amanda Ie, Katharina Eibenberger, Gerd Uwe Auffarth, Kanmin Xue

“…The number of glaucoma drugs were increased in 45% of patients during Densiron tamponade. …”
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Active Theater as a Complementary Therapy for Parkinson's Disease Rehabilitation: A Pilot Study by Nicola Modugno, Sara Iaconelli, Mariagrazia Fiorlli, Francesco Lena, Imogen Kusch, Giovanni Mirabella

“…Thus, to achieve a global improvement in personal well-being, not only drugs, but also complementary therapies, such as physical exercise, occupational and speech therapy, and active music therapy, have been used. …”
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Current developments in robotic assistance technology for total knee arthroplasty: a comprehensive overview by Hongli Zhang, Xing-an Jiang, Bing-chen Jin, Hong-hao Zhang, Jun-bo Liang

“…At present, the conservative treatment for knee arthritis is mostly using anti-inflammatory and analgesic drugs, but the effect is mostly temporary, and can not prevent its progress and surgery is usually the last treatment method. …”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…The survival rate of PAM remains very low, despite the use of multiple drugs and supportive care. Therefore, there is an urgent need for more research on the pathogenesis of N. fowleri and the identification of novel targets for intervention. …”
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Dose-response relationship between lipids and all-cause mortality in the dialysis population: a meta-analysis by Ye Yao, Jing Xiong, Mi-Yuan Wang

“…Abstract Background The use of lipid-lowering drugs in the dialysis population has been controversial and there is no target for the dialysis population. …”
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Factors associated with knowledge on the spread of HIV/AIDS among Secondary School Students of Groupe Scolaire De Rugando in Kigali City, Rwanda. by Nwankwo, Chinenye Mercy, Uwizeye, Denyse Sibomana

“…This study recommends the need to design interventions that aim to raise awareness of the negative consequences of risky sexual behaviors; increase the availability and accessibility of condoms; fight against the entry of drugs into the country as well as their circulation and accessibility to the youth and finally, guidance and counseling services should be introduced in schools.…”
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Experiences and Perceptions on Community Client-Led ART Delivery (CCLADS) Model of Antiretroviral (ART) Delivery: Patients’ and Providers’ Perspectives in South Western Uganda. by Kasande, Meble, Tusimiirwe, Happiness, Taremwa, Michael, Lamulatu, Kabiite, Amanyire, Mark, Nakidde, Gladys, Kabami, Jane

“…Benefits to ALHIV included: Longer refills, reduced transport costs, receiving drugs in time, and peer advice; to providers: time-saving, less tiresome, and reduced congestion at the facility. …”
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Civil Servants and Political Leaders’ Performance in Service Delivery in Kisoro District Local Government, Uganda. by Zigira Sam, Niyonzima

“…From the findings, it was established that monitoring and supervision ensures timely reports are produced and disseminated to all stakeholders in health which ensures constant supply/delivery of medical facilities and drugs. It was established that corruption, limited revenue and financing, human resource incapacity, Conflict between civil servants and political leaders, lack of coordination between local authorities and extension service delivery workers hinder effective performance of civil servants and political leaders in ensuring effective service delivery. …”
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Factors associated with knowledge on the spread of HIV/AIDS among Secondary School Students of Groupe Scolaire De Rugando in Kigali City, Rwanda by Mercy Nwankwo, Chinenye, Denyse Sibomana, Uwizeye

“…This study recommends the need to design interventions that aims to raise awareness on the negative consequences from risky sexual behaviors; increase availability and accessibility of condoms; fight against the entry of drugs in the country as well as their circulation and accessibility to the youth and finally, guidance and counseling services should be introduced in schools.…”
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The Application of Incretin-Based Pharmacotherapy in the Contemporary Management of Type 2 Diabetes: A Review of the Literature by Jakub Waszczyński, Wojciech Kulej, Wiktor Biesiada, Piotr Kulej, Justyna Woźniak, Justyna Weronika Kmieć, Anna Mariia Chernysh, Aleksandra Dusińska, Kamila Fuczyło, Karolina Stankević

“…., 15.2% with semaglutide). These drugs also improved glycemic and metabolic parameters, though initial gastrointestinal side effects were common but temporary. …”
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Management of tuberculosis risk, screening and preventive therapy in patients with chronic autoimmune arthritis undergoing biotechnological and targeted immunosuppressive agents by Andrea Picchianti-Diamanti, Alessandra Aiello, Chiara De Lorenzo, Giovanni Battista Migliori, Delia Goletti

“…Several systematic reviews have analysed the impact of anti-TNF-α agents on the risk of TB in patients with chronic autoimmune arthritis, as well as for other biologic disease-modifying immunosuppressive anti-rheumatic drugs (bDMARDs) such as rituximab, abatacept, tocilizumab, ustekinumab, and secukinumab. …”
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Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes by Weiyun Wang, Yaru Chu, Yunkun Lu, Jie Xu, Weixuan Zhao, Zhuo Liang, Xueqiang Guo, Lingling Xi, Tao Han, Yaping Shen, Wenjuan Song, Yanhua Tang, Mengnan Wen, Zhuang Qian, Lei Wang, Zhenlin Fan, Guangdong Zhou, Wenjie Ren

“…Osteoarthritis (OA) is the most prevalent joint disease, yet effective disease-modifying OA drugs (DMOADs) remain elusive. Targeting macrophage polarization has emerged as a promising avenue for OA treatment. …”
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A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment by Yuanhui Wang, Jie Gao, Ziyi Ren, Ziyi Shen, Wei Gu, Qinyi Miao, Xiaomeng Hu, Xiaomeng Hu, Yan Wu, Yan Wu, Wei Liu, Jia Jia, Jia Jia, Yi Cai, Chunpeng (Craig) Wan, Lei Sun, Tingdong Yan, Tingdong Yan

“…Compounds that are negatively correlated with the expression levels of the HOX family in various cancers, such as HDAC inhibitors, are potential anti-cancer drugs. HOXB7 and HOXC6 may serve as potential targets for cancer treatment and the development of targeted compounds in the future.…”
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Clinical features of cystic neutrophil granulomatous mastitis in 62 cases by Mengjie Wang, Dongxiao Zhang, Na Fu, Min Liu, Hongkai Zhang, Shuo Feng, Yifei Zeng, Wenjie Zhao, Jianchun Cui, Khattak Mazher Mansoor

“…Among the 62 patients, some patients had a history of oral psychotropic drugs, hyperprolactinemia, pituitary tumors, non-puerperal mastitis (NPM), and breast trauma history, or a family history of breast cancer. …”
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Therapeutic effects of cyclophosphamide, dsDNA preparations and combinations thereof against Krebs-2 ascites cancer cells and various cancer transplants by E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Existence of a small subset of cancer cells referred to as tumor initiating stem cells (TISCs) largely responsible for tumor progression and resistance to chemotherapeutic cytostatic drugs reperesent an important recent paradigm shift. …”
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Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 by You Ning, Jianhua Huang, Bill Kalionis, Qin Bian, Jingcheng Dong, Junzhen Wu, Xiantao Tai, Shijin Xia, Ziyin Shen

“…NSCs open a new way of treatment of the injured central nervous system and neurodegenerative disorders. Thus far, few drugs have been developed for controlling NSC functions. …”
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Impact of a pharmaceutical care service for patients with rheumatoid arthritis using a customised mobile device (the PROUD trial): study protocol for a randomised controlled trial by Jung-Yoon Choe, Hwajeong Lee, Yun-Kyoung Song, Seong-Kyu Kim, Ji-Won Kim, Ji-Eun Park, Ju-Eun Lee, Bo-Kyung Moon, Sung-Hoon Park

“…This study aims to analyse the effect of a telepharmacy service with a customised mobile device in comparison with the usual pharmacist service on the humanistic and clinical outcomes in patients with RA.Methods and analysis The study is designed as a prospective, randomised, open-label, and controlled trial to compare the humanistic and clinical outcomes of the pharmaceutical care service with monthly telecommunications and a customised mobile application (telepharmacy care group) against the usual service by community pharmacists (usual care group) in 256 patients with RA and prescribed at least one of the disease-modifying antirheumatic drugs. Participants will be recruited from a tertiary hospital in Republic of Korea with written informed consent. …”
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