Reduction of depressive symptoms among patients with inflammatory bowel disease treated with biological therapy: a quantitative comparative incision study by J. Zinkevičiūtė, S. Ambrasas, A. Kiziela, R. Strumila, S. Brašiškienė, E. Dlugauskas

“…Participants were divided into an experimental group (receiving tumor necrosis factor-alpha inhibitors) and control group (receiving treatment with other drugs). Results. 46 patients’ data were analysed. …”
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Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry by Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu

“…Aggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact on the stability and safety of the drugs. So far, investigational efforts have primarily focused on understanding the causes and effects of mAb self-aggregation, including both internal and external factors. …”
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Epidemiological and sociodemographic description of snakebite envenoming cases in Paraguay reported between 2015 and 2021 by Guillermo Sequera, Sofia Ardiles-Ruesjas, Edgar Sanabria, Victor Hugo Segovia Portillo, Lorena Jara Oroa, Viviana de Egea, Julio Alonso-Padilla, Irene Losada, María Jesús Pinazo

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Antibiotic Use and Resistance Pattern in Ethiopia: Systematic Review and Meta-Analysis by Oumer Abdu Muhie

“…In the absence of the development of new generations of antibiotic drugs, appropriate use of existing antibiotics is needed to ensure the long-term availability of effective treatment for bacterial infections. …”
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The Analysis of Dynamic Changes and Prognosis of Posner–Schlossman Syndrome with Cytomegalovirus Infection and Antiviral Therapy by Qilian Sheng, Ruyi Zhai, Xintong Fan, Xiangmei Kong

“…All patients were treated with intraocular pressure-lowering drugs and anti-inflammatory steroids. 2% ganciclovir eye drops were given to cytomegalovirus (CMV) immunoglobulin G (IgG) correction ratio positive patients. …”
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Relationship between CYP2C19 Polymorphism and Clopidogrel Resistance in Patients with Coronary Heart Disease and Ischemic Stroke in China by Rong Chang, Wenqin Zhou, Yi Ye, Xiaofei Zhang, Yanmin Liu, Jinchun Wu

“…From June 2019 to January 2020, patients who were diagnosed with coronary heart disease or cerebral infarction in internal medicine of Qinghai Provincial People’s Hospital and had taken dual antiplatelet drugs were included in this study. Blood was collected and routine items were completed. …”
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The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial by Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen

“…Compound reserpine and triamterene tablets, a traditional Chinese quadruple single-pill combination, have been proven to have good antihypertensive effects as well as safety, and are promising effective antihypertensive drugs for treating RH. Methods A randomized crossover clinical trial will be conducted to compare the efficacy and safety of compound reserpine and triamterene tablets treatment regimen (two tablets of olmesartan/amlodipine (OA) + one tablet of compound reserpine and triamterene tablets) with those of a standard treatment regimen (two tablets of OA + indapamide 2.5 mg + spironolactone 20 mg) in patients with RH. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…Finally, in the L1000 dataset, we identify drugs that can potentially be used to modulate expression of these genes. …”
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Differentiation of Isolated Small Bowel Crohn’s Disease from Other Small Bowel Ulcerative Diseases: Clinical Features and Double-Balloon Enteroscopy Characteristics by Meng Niu, Zheng-Hao Chen, Meng Li, Xing Zhang, Chun-Xiao Chen

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) used for more than two weeks decreased the probability of a diagnosis of ISBCD (OR 0.173, 95% CI 0.043-0.695, p=0.013). …”
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VARTOTOJO SUVERENUMAS: TEORIJA IR PRAKTIKA by Zenonas Norkus

“…This regulation includes prohibition to consume some products (e. g. drugs) and services, the restrictions (e. g. alcohol) on and sponsorship for consumption of some other products (e. g. theater performances). …”
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The epidemiology of Hepatitis B, C and D in Germany: A scoping review. by Gyde Steffen, Ida Sperle, Siv Aina Leendertz, Navina Sarma, Sandra Beermann, Roma Thamm, Viviane Bremer, Ruth Zimmermann, Sandra Dudareva

“…The population groups targeted in the identified studies included the general population and proxy populations, a range of clinical populations, people who inject drugs, men who have sex with men, healthcare workers, people in prisons and different migrant/mobile populations. …”
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Efficacy and Safety of Dapagliflozin versus Liraglutide in Patients with Overweight or Obesity and Type 2 Diabetes Mellitus: A Randomised Controlled Clinical Trial in Tianjin, Chin... by Hao Zhaohu, Huang Xiao, Shao Hailin, He Feng

“…After COVID-19 outbreak, the number of patients taking sleep-promoting drugs increased from 4.9% to 9.4% (p=0.029). Conclusions. …”
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A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…Other AEs including diarrhoea, gastric upset, dizziness and drowsiness were less frequent in the nicergoline group when compared with placebo/active drugs, but the difference was non-significant. Frequency of hypotension and hot flushes was slightly higher in the nicergoline group but the difference was non-significant. …”
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The production process of spring wheat plants in the system of biological agriculture by N. N. Shuliko, O. A. Yusova, A. A. Kiselyova, E. V. Tukmacheva, V. S. Yusov, E. V. Kubasova, I. A. Korchagina, A. Yu. Timokhin

“…‘Omskaya 42’ and ‘Omsky Korall’ with the stimulating fungicide drugs Mizorin and Flavobacterin. According to the values of the TCARI and SPAD indices, it is possible to opine on the potential nitrogen-fixing activity and the yield of a cultivar.…”
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New epigenome players in the regulation of PCSK9-H3K4me3 and H3K9ac alterations by statin in hypercholesterolemia by Sushmitha Duddu, Yash T. Katakia, Rituparna Chakrabarti, Pooja Sharma, Praphulla Chandra Shukla

“…Statins are the most effective drugs used worldwide to lower the serum LDL-C by inhibiting the rate-limiting step, HMG-CoA reductase, in cholesterol biosynthesis. …”
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A Case of Status Epilepticus in a Patient Experiencing an Acute Attack of Hereditary Angioedema by Danielle Weinberg, Steven Gayda, Kyle Hultz, Hanan Atia, Brian Kohen, Eric Boccio

“…The focus of emergent medical management of status epilepticus includes airway protection, respiratory support, and administration of abortive and prophylactic antiepileptic drugs. The emergency medicine physician should also consider and treat possible underlying etiologies. …”
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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…NPs possess unique properties such as small size, large surface area, and modifiable surface characteristics, enabling them to cross the BBB and deliver drugs directly to the affected brain regions. This review focuses on the application of NPs in gene therapy and enzyme replacement therapy (ERT) for neurological disorders. …”
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Mental health and substance use among rehabilitation sciences students during the COVID-19 pandemic by Itumeleng Ntatamala, Saajida Khan, Zenzo Chakara

“…Results: Substance use was common, including alcohol (54.05%), cigarettes and/or tobacco (17.27%), and illicit drugs (5.56%). Below a quarter (23.85%) self-reported a mental health condition in their lifetime and 14.81% in the past 12 months. …”
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Effect of different doses of ciprofol on hemodynamics induced by general anesthesia in elderly diabetic patients undergoing spinal surgery: a double-blind, randomized, controlled s... by Xiaorui Jiang, Linzhong Zhang, Jiawei Ji, Yan Jing, Meiping Li

“…Significant differences in bispectral index (BIS) values were observed at 3, 4, and 5 min post-administration among the groups Conclusions The induction regimen of 0.3 mg/kg ciprofol combined with 0.4 µg/kg sufentanil and 0.7 mg/kg rocuronium provided superior hemodynamic stability and reduced the need for vasoactive drugs in elderly diabetic patients. This regimen was found to be more favorable compared to the 0.2 mg/kg and 0.4 mg/kg ciprofol dosing groups, demonstrating an optimal balance of safety and efficacy during anesthesia induction in this high-risk population. …”
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Surgical Treatment Patterns, Healthcare Resource Utilization, and Economic Burden in Patients with Tenosynovial Giant Cell Tumor Who Underwent Joint Surgery in the United States by Feng Lin, Winghan J. Kwong, Sherry Shi, Irina Pivneva, Eric Q. Wu, John A. Abraham

“…Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs), and physical therapy, occupational therapy, and rehabilitation services, were commonly used during baseline (45%, 40%, and 30%, respectively). …”
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