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The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance
Published 2012-01-01“…The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to achieve maximal virological response and reduce the potential for the emergence of antiviral resistance. …”
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943
Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions
Published 2015-01-01“…Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). …”
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944
Evaluating a novel team learning approach for integrating drugs in sports education in preclinical medical training
Published 2025-02-01Subjects: “…performance-enhancing drugs…”
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945
Genetic association of lipid-lowering drug target genes with pancreatic cancer: a Mendelian randomization study
Published 2025-01-01“…Our findings do not support dyslipidemia as a causal factor for PC. Among lipid-lowering drug targets, LPL is the potential drug target in PC.…”
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946
Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review
Published 2025-06-01“…Drug residues have been detected in aquatic environments around the world and non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most used classes. …”
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947
Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A
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948
Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective
Published 2014-01-01“…Over the years, clinical use has raised concerns about the degree of drug exposure following standard approved drug dosing, questioning the need for therapeutic drug monitoring (TDM). …”
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949
Analysis of poisoning with OTC drugs for suicidal purposes among children and adolescents in Poland in the period 2012 - 2023
Published 2025-02-01“… Introduction and Purpose: Drug poisoning among children and adolescents is an increasing public health issue worldwide and in Poland. …”
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950
A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy
Published 2024-08-01“…The synthesized MSN@R837-Mn/ZnO2 nanoparticles exhibited precise tumor targeting and accumulation, controlled drug release under acidic conditions, and increased sensitivity in magnetic resonance imaging. …”
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951
An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats
Published 2025-05-01“…Purpose: In this study, the PK and PD interactions of GP (0.82 mg/kg) with IME-9 (132.24 mg/kg p.o.) was studied in diabetic rats (induced by Nicotinamide-STZ) by concomitant administration of both the drugs orally for a period of 21 days. Methods: The RP-HPLC technique was devised and validated in accordance with the guidelines set by the US Food and Drug Administration (FDA). …”
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Is epinephrine still the drug of choice during cardiac arrest in the emergency department of the hospital? A meta-analysis
Published 2023-09-01“…Epinephrine is the first-line emergency drug for cardiac arrest and anaphylactic reactions but is reported to be associated with many challenges resulting in its under- or improper utilization. …”
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Predicting drug combination side effects based on a metapath-based heterogeneous graph neural network
Published 2025-01-01Subjects: “…Combinatorial drugs…”
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Conventional and drug‑eluting bead transarterial chemoembolization in patients with inoperable intrahepatic cholangiocarcinoma: a meta‑analysis
Published 2024-11-01Subjects: Get full text
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Characterization of tumor prognosis and sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer
Published 2025-01-01“…Ultimately, our analysis compared the two groups across various dimensions, including clinical characteristics, tumor progression, metabolism-related pathways, immune landscape, and drug sensitivity. Results MTF1 and LIAS were identified as protective factors in ovarian cancer, with patients in the higher risk group being significantly associated with poorer survival. …”
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956
Exploring the Infectious Drug Target Glutathione S-Transferase in Plasmodium falciparum with the Inhibitory Potential of Azadirachta indica Phytocompounds
Published 2024-01-01“…Neem compounds are being studied for their potential as new and effective antimalarial drugs, and there is mounting evidence that they may help treat malaria. …”
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Development and In Vitro Characterization of Hyaluronic Acid-Based Coatings for Implant-Associated Local Drug Delivery Systems
Published 2013-01-01“…The development of drug-eluting coatings based on hyaluronic acid (HA) is especially promising for implant-associated local drug delivery (LDD) systems, whose implantation provokes high insertion forces, as, for instance, cochlear implants or drug-coated balloons (DCB). …”
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Bilateral Femoral Neuropathy: A Rare Complication of Drug Overdose due to Prolonged Posturing in Lithotomy Position
Published 2020-01-01“…To our knowledge, this is the first reported case of bilateral femoral nerve palsy due to prolonged posturing in a “lithotomy-type” position in the context of a drug overdose.…”
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