Prevalence of nasopharyngeal bacteria during naturally occurring bovine respiratory disease in commercial stocker cattle by Afroza Akter, Hannah Teddleton, Marc Caldwell, Gina Pighetti, Phillip R. Myer, Madison T. Henniger, Liesel Schneider, Elizabeth Shepherd

“…Prophylactic use of antimicrobial drugs can alter the microbial communities in the respiratory tract. …”
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Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedi... by Marie C. Hyslop, Diana E. Papaioannou, Robert Bolt, Matthew J. Wilson, Michael Bradburn, Janet Clarkson, Esther Herbert, Nicholas Ireland, Jennifer Kettle, Amanda Loban, Amy C. Norrington, Christopher Vernazza, Christopher Deery

“…Future paediatric perioperative medicine trials could consider funding for research pharmacy outside of working hours; conducting risk assessments for study drugs to be held on theatre admission units; and a tailored design of site feasibility assessments to help address variation in practice. …”
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Polyphenols of <i>Perilla frutescens</i> of the family Lamiaceae identified by tandem mass spectrometry by M. P. Razgonova, N. G. Kon’kova, A. M. Zakharenko, K. S. Golokhvast

“…A wide range of biologically active compounds opens up rich opportunities for the creation of new drugs and dietary supplements based on extracts of perilla of the family Lamiaceae, subfamily Lamioideae, tribe Satureji and subtribe Perillinae.…”
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Immunotherapy in metastatic renal cell carcinoma: Insights from a Dutch nationwide cohort by Hilin Yildirim, Anke Richters, Adriaan D. Bins, Arnoud W. Postema, Maureen J.B. Aarts, Martijn G.H. van Oijen, Patricia J. Zondervan, Katja K.H. Aben

“…Patient summary: Since 2019, systemic treatments for metastatic kidney cancer have shifted from drugs targeting selected proteins to immunotherapy. …”
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Clinical Holistic Medicine (Mindful, Short-Term Psychodynamic Psychotherapy Complemented with Bodywork) Improves Quality of Life, Health, and Ability by Induction of Antonovsky-Sal... by Søren Ventegodt, Suzette Thegler, Tove Andreasen, Flemming Struve, Lars Enevoldsen, Laila Bassaine, Margrethe Torp, Joav Merrick

“…For these patients, the treatment provided lasting benefits, without the negative side effects of drugs. A lasting, positive effect might also prevent many different types of problems in the future. …”
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Synthesis and Antioxidant Activity of Selenized Apigenin by Yawen GAO, Guopeng WU, Bo HAN, Rongwu WANG, Fangming LOU

“…Therefore, the present data indicated that selenylation modification of AP could increase the antioxidant activity and enhance the biological activity, which could offer the possibility of the development and utilization of selenized flavonoid-related foods and drugs.…”
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Sofosbuvir Based Regimens in the Treatment of Chronic Hepatitis C with Compensated Liver Cirrhosis in Community Care Setting by Vijay Gayam, Amrendra Kumar Mandal, Mazin Khalid, Osama Mukhtar, Arshpal Gill, Pavani Garlapati, Mowyad Khalid, Mohammed Mansour

“…Direct-acting antiviral (DAA) drugs have been highly effective in the treatment of chronic hepatitis C (CHC) infection. …”
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Opioid Prescription Patterns for Discharged Patients from the Emergency Department by Justin Yanuck, Jonathan B. Lee, Soheil Saadat, Jila Rouhi, Ghadi Ghanem, Bharath Chakravarthy, Shalini Shah

“…Mounting evidence of the potential for abuse of these drugs, even after a transient ED encounter, has fueled a push to curtail the prescriptions of opioids from the ED. …”
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Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance by Chang-Nim Im, Byeong Mo Kim, Eun-Yi Moon, Da-Won Hong, Joung Whan Park, Sung Hee Hong

“…H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.…”
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The development and validation of an UV-Vis spectrophotometric method for the determination of ciprofloxacin in raw material and dosage forms by Timothé Mavanga Mabaya, Jocelyn Mankulu Kakumba, Mannix Mayangi Makola, Adelard Mbenza Puati, Didi Mana Kialengila, Jean Mavar Tayey Mbay, Jeremie Mbinze

“…With the growing problem of counterfeit drugs, it is important to protect the population from substandard medicines and equip professionals with effective analysis tools. …”
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<i>Zanthoxylum piperitum</i> Benn. Attenuates Monosodium Urate-Induced Gouty Arthritis: A Network Pharmacology Investigation of Its Anti-Inflammatory Mechanisms by Sung Wook Kim, Soo Hyun Jeong, Jong Uk Kim, Mi Hye Kim, Wonwoong Lee, Cheol-Jung Lee, Tae Han Yook, Gabsik Yang

“…The necessity for alternatives with fewer side effects is underscored by the frequent adverse effects of conventional therapies, such as urate-lowering drugs. IL-1β is a potential therapeutic target due to its significant role in the inflammatory response induced by MSU. …”
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Anti-motilities and anti-biofilm effects of Ageratum conyzoides L. methanol extract by Eli Compaoré, Moussa Compaoré, Vincent Ouédraogo, Ablassé Rouamba, Alimata Bancé, Mignini R. Dofini, Martin Kiendrebeogo

“…Conclusion: From this study the anti-biofilm and anti-motility potential of the A. conyzoides extract provided the experimental background for the further development of antibacterial drugs. Contribution: This study provided additional scientific evidence to support the use of A. conyzoides in traditional medicine against bacterial infections.…”
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The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin—A Randomized, Controlled, Crossover Study by Liva K. Stuhr, Joshua B. Feinberg, Thea Christoffersen, Konstantinos Dimopoulos, Mikkel B. Christensen, David P. Sonne, Troels Riis, Peter S. Plomgaard, Jens P. Goetze, Emil L. Larsen, Kristian Karstoft

“…ABSTRACT Exercise increases blood and lymph flow in working muscles, potentially affecting the bioavailability and effect of subcutaneously administered drugs. The aim of this study was to assess the influence of a single exercise session on pharmacokinetics and pharmacodynamics of a single dose of subcutaneously administered unfractionated heparin. …”
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Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma by Yihong Li, Xuejie Yang, Zhen Wei, Heng Niu, Liyang Wu, Caijing Chen, Huina Liu, Ting Cai, Huadong Fan

“…<b>Background/Objectives:</b> The two obstacles for treating glioma are the skull and the blood brain–barrier (BBB), the first of which forms a physical shield that increases the difficulties of traditional surgery or radiotherapy, while the latter prevents antitumor drugs reaching tumor sites. To conquer these issues, we take advantage of the high penetrating ability of sonodynamic therapy (SDT), combined with a novel nanocomplex that can easily pass the BBB. …”
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Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(N,N-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance by Samuel Treviño, Alfonso Díaz, Eduardo Sánchez-Lara, Víctor Enrique Sarmiento-Ortega, José Ángel Flores-Hernández, Eduardo Brambila, Francisco J. Meléndez, Enrique González-Vergara

“…Vanadium(IV/V) compounds have been studied as possible metallopharmaceutical drugs against diabetes mellitus. However, mechanisms of action and toxicological threshold have been tackled poorly so far. …”
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Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit by Guo Tang, Tianshan Zhang, Ping Zhang, Sha Yang, Tao Cheng, Rong Yao

“…Patients were divided into ICU and non-ICU groups based on admission criteria including the need for blood purification therapy, organ support therapy (ventilatory support, vasoactive drugs, renal replacement therapy, artificial liver), or post-cardiopulmonary resuscitation. …”
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Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis by Jie Wang, Kaijie Qiu, Songsheng Zhou, Yichao Gan, Keting Jiang, Donghuan Wang, Haibiao Wang

“…Lifestyle habits such as smoking and alcohol use significantly increase HCC risk, highlighting the importance of cessation. Certain drugs like aspirin, statins, GLP-1 RAs, and metformin may reduce HCC occurrence, but further research is needed to confirm these effects.…”
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Risankizumab Versus Secukinumab: A Real-World Efficacy and Cost per Responder Comparison in Patients With Psoriasis in Italy by Federico Pirro, Giacomo Caldarola, Nicoletta Bernardini, Maria Grazia Celeste, Annunziata Dattola, Eleonora De Luca, Marco Galluzzo, Domenico Giordano, Chiara Izzi, Giulia Maretti, Lorenzo Marcelli, Roberto Ravasio, Antonio Giovanni Richetta, Nevena Skroza, Marina Talamonti, Arianna Zangrilli, Luca Bianchi, Giovanni Pellacani, Severino Persechino, Concetta Potenza, Ketty Peris, Clara De Simone

“…Objective: We sought to estimate the efficacy and the cost per responder of risankizumab and secukinumab by comparing these two drugs in a real-life setting. Methods:.A multicentric retrospective study was conducted in patients from the Lazio region of Italy affected by moderate-to-severe psoriasis who initiated risankizumab or secukinumab between September 2020 to September 2022. …”
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A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India by Sanjiv Jasuja, Gaurav Sagar, Anupam Bahl, Neharita Jasuja, Rajesh Chawla, Avdhesh Bansal, Manjit. S. Kanwar, Sudha Kansal, Nikhil Modi, Athar P. Ansari, Viny Kantroo, Purnima Dhar, Chitra Chatterjee, Nitin Ghonge, Samir Tawakley, Shalini Verma

“…Strategies to modify immunosuppressants such as discontinuation of antinucleoside drugs with or without change in calcineurin inhibitors and the use of steroids were similar during both waves. …”
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Effectiveness of Steroid Pulse Therapy for Systemic Side Effects after Bacillus Calmette-Guérin Intravesical Instillation Therapy: A Series of Five Cases by Tatsuya Umemoto, Jun Naruse, Yukio Usui, Hidenori Zakoji, Hideshi Miyakita, Akira Miyajima

“…In the case of BCG sepsis, hemodialysis and mechanical ventilation were required because of septic shock and acute renal failure. Antituberculosis drugs (isoniazid, rifampicin, and ethambutol) were started promptly; however, no improvement was noticed. …”
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