Restructuring of Global Pharmaceutical Supply Chains after COVID-19 by N. A. Volgina

“…The paper proposes one of the possible classifications of pharmaceutical chains depending on the technologies used, where the following are distinguished: low-tech and medium-low-tech chains (production of essential pharmaceutical goods); medium-high-tech chains (production of generics); high-tech chains (production of patented drugs, production of biopharmaceuticals, production of medical equipment). …”
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Decline of adolescent smoking in Ireland 1995–2015: trend analysis and associated factors by Shasha Li, Sheila Keogan, Luke Clancy, Keishia Taylor

“…Objectives The study examines trends in smoking among Irish adolescents aged 15–16 years between 1995 and 2015 and the factors associated with their smoking behaviours between 2007 and 2015.Methods Data were obtained from the European School Survey Project on Alcohol and Other Drugs Ireland between 1995 and 2015. To examine the gender gap, two-sample proportion tests were used. …”
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Comparison of Antioxidant and Alpha-Glucosidase Inhibitory Properties of Moringa peregrina and Ferulago carduchorum Leaf Extracts and Microencapsulation of Superior Plant by Shiva Nouri, Maryam Moslehishad, Seyede Marzieh Hosseini, Mina Etemadi

“…These plants do not impose any side effects owing to their bioactive compounds in comparison with chemical drugs. Several studies have demonstrated antioxidant capacity and α-glucosidase inhibitory effects of bioactive compounds from medicinal plants. …”
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Are the Menstrual Characteristics Similar in Adolescent and Adult Women with Cerebral Palsy? by Hanife Dogan, Duygu Turker, Ozge Coban, Merve Basol Goksuluk, Nuriye Ozengin, Necmiye Un Yildirim

“…The menstrual suppression treatment, length of menstruation, pain onset time, pain duration, pain medicine usage during menstruation, the highest intensity of pain experienced during the menstrual period, number of drugs, use of pain relief methods, number of days absent from school or work, type and the number of menstruation products, presence and the reason of discomfort scores of questions and gross motor function classification system expanded and revised levels were similar in both groups (p>0.05). …”
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Assessing the impact of antimicrobial resistance policies on antibiotic use and antimicrobial resistance-associated mortality in children and adults in low and middle-income countr... by Günther Fink, Jay Patel, Kyaw Zay Ya

“…We observed strong evidence of negative association (mean difference MD=−0.150, 95% CI (−0.2593 to –0.0407)) between the presence of regulatory or legislative policies that ban over-the-counter sales of antibiotics and the proportion of children receiving antibiotic drugs for lower respiratory tract infection. Furthermore, stronger AMR governance was associated with reduced total antibiotic consumption at the country level (MD=−1.259, 95% CI (−2.297 to –0.2216)). …”
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The Contribution of Lower Local Governments to Health Service Delivery in Kabale Municipality Kabale District: A Case Study of Rushoroza Hospital. by Ayebare, Rosette

“…The study recommends that the government of Uganda should strengthen the national supply chain for essential health commodities to ensure that Ugandans have access to necessary drugs.…”
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Treatment of inoperable pancreatic adenocarcinoma with focused ultrasound and microbubbles in patients receiving chemotherapy by Margrete Haram, Rune Hansen, Ola Finneng Myhre, Stian Solberg, Naseh Amini, Bjørn Atle Angelsen, Catharina de Lange Davies, Eva Hofsli

“…Objective: Preclinical trials have demonstrated promising results for increased tumor uptake and therapeutic effect of drugs combined with focused ultrasound (FUS) and microbubbles (MBs). …”
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Koumine Attenuates Neuroglia Activation and Inflammatory Response to Neuropathic Pain by Gui-Lin Jin, Sai-Di He, Shao-Mei Lin, Li-Mian Hong, Wan-Qing Chen, Ying Xu, Jian Yang, Su-Ping Li, Chang-Xi Yu

“…Despite decades of studies, the currently available drugs largely fail to control neuropathic pain. Koumine—an alkaloidal constituent derived from the medicinal plant Gelsemium elegans Benth.…”
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Rituximab (monoclonal anti-CD20 antibody) induced posterior reversible encephalopathy syndrome (PRES): A case report and literature review by Praveen K. Sharma, MD, Sanjaykanth Balachandar, MBBS, Michael Antony Vikram, MBBS, Pujitha Duvooru Sukumar, MD

“…Rituximab is promptly discontinued, and the patient was managed with supportive care, including antiepileptic drugs and blood pressure control. Within days of Rituximab cessation, the patient showed gradual improvement in symptoms, with resolution of cortical blindness and normalization of MRI findings. …”
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Prone Positioning and Intravenous Zanamivir may Represent Effective Alternatives for Patients with Severe ARDS Virus A (H1N1) Related Pneumonia in Hospitals with no Access to ECM... by Giuseppe Gristina, Giuseppe Nardi, Daniela Orazi, Francesco Nicola Lauria, Maria Beatrice Valli, Eleonora Lalle, Stefano Menzo, Luigi Riccioni, Maria Pia Camporiondo

“…However, prone positioning ventilation is often associated with severe impairment of the absorption of drugs that require enteral administration via the nasogastric tube. …”
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CoviWall, a whole-virion-inactivated B.1.617.2 vaccine candidate, induces potent humoral and Th1 cell response in mice and protects against B.1.617.2 strain challenge in Syrian ham... by Jyotsna Dandotiya, Neeta Adhikari, Manas Ranjan Tripathy, Manas Ranjan Tripathy, Kamini Jakhar, Sudipta Sonar, Dibya Ranjan Pati, Vibhu Kanchan, Varsha S. Prasad, Jitendra Kumar, Nitesh K. Senapati, Arti Bharmoria, Neeraj Rani, Monika Lakhanpal, CS. Patil, Nishan Singh, Lovely Khan, Lavit Jambu, Naveen K. Jain, Syed Khalid Ali, Priyanka Priyadarsiny, Amulya K. Panda, Rajesh Jain, Shailendra Mani, Sweety Samal, Amit Awasthi, Amit Awasthi, Zaigham Abbas Rizvi, Zaigham Abbas Rizvi

“…Rapid development of coronavirus disease 2019 (COVID-19) vaccines and antiviral drugs have significantly reduced morbidity and mortality worldwide. …”
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Isolation and identification of novel casein-derived bioactive peptides and potential functions in fermented casein with Lactobacillus helveticus by Mengzhu Fan, Tingting Guo, Wanru Li, Jing Chen, Fushuo Li, Chao Wang, Yi Shi, David Xi-an Li, Shaohui Zhang

“…The new sources of natural bioactive peptides may have the very high application value as potential new peptide drugs for treatment human diseases. The product peptide DELQDKIHPF found in both extracell and intracell was quantitatively analyzed using the MRM mode of UPLC-U3Q, 23.1 and 9.76 ng/mL, respectively. …”
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The Effects of Tormentic Acid and Extracts from Callistemon citrinus on Candida albicans and Candida tropicalis Growth and Inhibition of Ergosterol Biosynthesis in Candida albicans by Chido Bvumbi, Godloves Fru Chi, Marc Y. Stevens, Molly Mombeshora, Stanley Mukanganyama

“…There is an increase in resistance of Candida pathogens to existing antifungal drugs leading to a need to find new sources of antifungal agents. …”
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Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies by Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel, Srinath Kasturirangan

“…However, many BsAbs exhibit unfavorable PK, which has precluded their development as drugs. In this report, we present studies on the molecular determinants underlying the distinct PK profiles of three IgG1-scFv BsAbs. …”
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Silver Trimolybdate (Ag2Mo3O10.2H2O) Nanorods: Synthesis, Characterization, and Photo-Induced Antibacterial Activity under Visible-Light Irradiation by Maria Karollyna do Nascimento Silva Leandro, João Victor Barbosa Moura, Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Cicera Laura Roque Paulo, Amanda Karine de Sousa, Janaina Esmeraldo Rocha, Lívia Maria Garcia Leandro, Rakel Olinda Macedo da Silva, Clenilton Costa dos Santos, Jaime Ribeiro-Filho, Cleânio da Luz Lima, Abolghasem Siyadatpanah, Zahra Seifi, Bonglee Kim, Henrique Douglas Melo Coutinho

“…While showing the potential use to combat antibacterial resistance, the simultaneous combination of silver trimolybdate, visible LED lights, and antibacterial drugs should be carefully analysed to avoid antagonist effects that could impair the effectiveness of antibiotic therapy.…”
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Targeting Cytokine Storm in COVID-19: A Role of Online Hemodiafiltration with Asymmetric Cellulose Triacetate in Maintenance Hemodialysis Patients—A Report of 10 Cases by José C. De La Flor, Francisco Valga, Alexander Marschall, Tania Monzon, Cristina Albarracín, Elisa Ruiz, Miguel Rodeles

“…Among the therapeutic approaches, the use of drugs that reduce the cytokine storm characteristic of this disease has been proposed. …”
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Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease by Tawfik Khoury, Amir Mari, Hana Amara, Mohamed Jabaren, Abdulla Watad, Wiliam Nseir, Wisam Sbeit, Mahmud Mahamid

“…Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies. …”
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In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

“…The rapid development of mRNA drugs highlights the potential of mRNA-encoded ACE2 decoys in emergencies to combat diverse SARS-CoV-2 variants, including future variants.…”
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Clinical and Functional Characteristics of a Novel KLF11 Cys354Phe Variant Involved in Maturity-Onset Diabetes of the Young by Yujing Sun, Jingru Qu, Jing Wang, Ruxing Zhao, Chuan Wang, Li Chen, Xinguo Hou

“…Therefore, administering oral antidiabetic drugs along with dietary intervention may benefit the proband.…”
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PARP inhibitors in the treatment of Pancreatic Cancer - A Review of literature by Jagoda Niewiadomska, Wiktor Grela, Daria Furtak, Dawid Tulej, Paulina Głogowska, Alicja Dziedzic, Natalia Gniaź, Dominika Marciniuk, Natalia Marko, Aleksandra Górska

“…The changes in treatment outcomes that these drugs can bring underscore the importance of exploring new therapeutic strategies in oncology. …”
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