Hemorrhagic syndrome at liver cirrhosis by I. A. Kurkina, O. S. Volkova, M. V. Mayevskaya, V. T. Ivashkin

“…Basic principles of therapy are: application of erythrocytes, plasma, platelets concentrate, recombinant factor VIIa, concentrates of prothrombin complex, desmopressin, antifibrinolytic drugs, thrombo-and erythropoietin, antibiotics. The relation to prescription of components of blood is cautious now, there are no definite indications to their application and criteria of efficacy.Conclusion. …”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…IntroductionThe functionalization of nanoparticles (NPs) with an antiCD19 targeting mechanism represents a promising approach for the selective delivery of drugs and nucleic acids into normal and tumor B cells. …”
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Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge by Shahram Darabi, Enam Alhagh Charkhat Gorgich, Fatemeh Moradi, Auob Rustamzadeh

“…Given the relationship between lipid profiles and Aβ levels, along with lipid-modifying drugs, may be effective in managing Aβ accumulation and mitigating AD progression.…”
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From Anatase TiO₂ Nano-Cuboids to Nano-Bipyramids: Influence of Particle Shape on the TiO₂ Photocatalytic Degradation of Emerging Contaminants in Contrasted W... by Humaira Asghar, Daphne Hermosilla, Francesco Pellegrino, Virginia Muelas-Ramos, Christian de los Ríos, Antonio Gascó, Valter Maurino, Muhammad Ahsan Iqbal

“…This research work explores the influence of shape-controlled nanocrystalline titanium dioxide (TiO₂ NC), synthesized by a simple hydrothermal method, on the photodegradation efficiency of three different classes of emerging environmental pollutants: phenol, pesticides (methomyl), and drugs (sodium diclofenac). Experiments were conducted to assess the influence of the water matrix on treatment efficiency by using ultrapure water and stormwater (basic) collected from an urban drainage system as matrices. …”
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Direct Effect of Two Naphthalene-Sulfonyl-Indole Compounds on Toxoplasma gondii Tachyzoite by Qasem Asgari, Hossein Keshavarz, Mostafa Rezaeian, Mohammad Hossein Motazedian, Saeedeh Shojaee, Mehdi Mohebali, Ramin Miri

“…If we consider a well-organized transporter mechanism for indole compounds in the parasite, thus the designation of an antagonist that has indole groups can assist with the production of new drugs.…”
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Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents by Amilton Dos Santos-Júnior, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Osmar Henrique Della Torre, Lúcia Arisaka Paes, Adriana Perez Ferreira-Neto, Letícia Esposito Sewaybricker, Thiago Salum Fontana, Eloisa Helena Rubello Valler Celeri, Gil Guerra-Júnior, Paulo Dalgalarrondo

“…Samples from 120 risperidone users (8–20 years old) were collected and SNPs were analyzed, alongside assessment of chronological and bone ages, prescribed and weight-adjusted doses, use of other psychotropic drugs, waist circumference, BMI z-scores, blood pressure, HOMA-IR index, fasting levels of serum glucose, insulin, cholesterol, triglycerides, transaminases, and leptin. …”
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The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001 by Kejian Tian, Fanxing Meng, Qi Meng, Yan Gao, Lili Zhang, Le Wang, Yuqing Wang, Xue Li, Hongliang Huo

“…Environmental estrogens are mainly derived from human and vertebrate excretion, drugs, and agricultural activities. The use of microorganisms is currently the most economical and effective method for biodegradation of environmental estrogens. …”
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Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition by Jiayu Zhang, Jianmin Peng, Siyu Wang, Li Wang, Yutong Sun, Juan Xia, Bin Cheng, Qinchao Hu

“…OSCC patients with higher PLIN2 expression possessed poorer prognosis and higher sensitivity to chemotherapy drugs (1S,3 R)-RSL3 and ML-210. In conclusion, PLIN2-dependent LDs accumulation could promote the metastasis of OSCC cells by regulating EMT. …”
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Evaluation of Phytochemical, Antioxidant, and Memory-Enhancing Activity of Garuga pinnata Roxb. Bark and Bryophyllum pinnatum (Lam) Oken. Leaves by Ravin Bhandari, Sabina Gyawali, Nisha Aryal, Devika Gaire, Kalpana Paudyal, Abaru Panta, Pooja Panth, Dirgha Raj Joshi, Rabindra Kumar Rokaya, Pramod Aryal, Jitendra Pandey

“…The memory-enhancing activity was determined by the elevated plus-maze method in Scopolamine-induced amnesic mice, using Piracetam as allopathic and Shankhpushpi as ayurvedic standard drugs. Two doses (200 and 400 mg/kg p.o.) of both extracts were administered to mice up to 8 consecutive days; transfer latency of individual group was recorded after 45 minutes and memory of the experienced things was examined after 1 day. …”
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Effect of low salicylate diet on clinical and inflammatory markers in patients with aspirin exacerbated respiratory disease – a randomized crossover trial by Leigh J. Sowerby, Krupal B. Patel, Crystal Schmerk, Brian W. Rotenberg, Taciano Rocha, Doron D. Sommer

“…Abstract Background Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, and bronchial asthma, along with the onset of respiratory reactions after the ingestion of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetylsalicylic acid (ASA). In addition to the therapeutic routines and surgical options available, a low dietary intake of food salicylate has been suggested as adjunctive therapy for this condition. …”
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miR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells by Virginie Joris, Elizabeth R. Balmayor, Martijn van Griensven

“…This work shows the complexity of drugs such as dexamethasone and opens the door for new in vitro models of mineralization.…”
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Anti-allergic effect of 5,7-dihydroxy-4-methylcoumarin in IgE-mediated RBL-2H3 cells and PCA murine model by Sugeun Gwon, Seong-Ah Shin, Moonsu Kim, Sun Young Moon, Seyeon Choi, Minji Kim, Jun Hyuck Lee, Hyun Ho Park, Chang Sup Lee

“…Collectively, these results suggest that 5,7-dihydroxy-4-methylcoumarin holds promise as a novel candidate for the development of anti-allergic drugs.…”
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Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1<i>H</i>-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1<i>H</i>,5<i>H</i>)... by Thanaa Abdul Ameer Hilal, Ibtihal Kadhim Kareem

“…The present investigation employs a comprehensive molecular docking analysis to assess the binding energies of anti-cancer drugs, thereby elucidating their binding affinity towards the receptor. …”
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Do antibody CDR loops change conformation upon binding? by Chu’nan Liu, Lilian M. Denzler, Oliver E.C. Hood, Andrew C.R. Martin

“…Antibodies have increasingly been developed as drugs with over 100 now licensed in the US or EU. …”
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Effects of hydrodynamic cavitation combined with snail enzyme treatment on the structure and functional properties of water-soluble dietary fiber in rice husks by Zhigang Quan, Mingming Chen, Dongjie Zhang

“…In summary, the synergistic modification of hydrodynamic cavitation and snail enzyme greatly optimized the structural and functional properties of rice husk SDFs, providing a theoretical basis for its application in the field of hypoglycemic drugs and functional foods.…”
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Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study by Hassan Shawa, Ferhat Deniz, Hadil Bazerbashi, Mike Hernandez, Rena Vassilopoulou-Sellin, Camilo Jimenez, Mouhammed Amir Habra

“…Understanding the mechanism of HDL change may lead to the discovery of novel HDL-c-elevating drugs.…”
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Characterization of Pregnant Women with Heart Disease at the “Ramón Gonzalez Coro” Gynecologic and Obstetric Teaching Hospital by Yanara Gutierrez Aliaga, Ileana Chio Naranjo, Elena Guerra Chang, Marlén Rodríguez Jorge, Mario Joel Arroyo Díaz, Mayelin Díaz Gutiérrez

“…They included: mothers’ age, first and third trimester functional classification, drugs used and cardiovascular complications. <strong><br />Results:</strong> valvular heart diseases (25, 6 %) were the most common type of heart disease. …”
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Beyond the Ear, the Hidden Threat of Paecilomyces Neuro-Otological Infection: A Case Report by Jing Hern Khoo, Izny Hafiz Zainon, Hafizah Husna Johari, Ida Sadja’ah Sachlin

“…It is vital to recognize such infections, and prompt surgical management with appropriate antifungal drugs is warranted to prevent disastrous outcomes.…”
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Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital by Susheera Chatproedprai, Vanvara Wutticharoenwong, Therdpong Tempark, Siriwan Wananukul

“…There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases of TEN. Drugs were the leading cause for the diseases (72.3%); antiepileptics were the most common culprits (36.1%). …”
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Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used in Management of Oral Lesion Pain in HIV/AIDS Patients in Rodents by Joseph Obiezu, Chukwujekwu Ezeonwumelu, Muhammad, Ntale, Steve, Okwudili Ogbonnia, Ezera, Agwu, Julius, Kihdze Tanayen, Ahmed, Adebowale Adedeji, Okonkwo, Chukwudi Onyeka, Ambrose, Amamchukwu Akunne, Jennifer, Chibuogwu Ebosie, Frederick, Byarugaba

“…However, the inability of rural dwellers to afford readily available drugs is a consequence for using herbs like Bidens pilosa whose local usefulness in the management of oral lesions of HIV/AIDS has not been proven scientifically. …”
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