Drug Clues for the Treatment of Fungal Catheter-Related Bloodstream Infection With Antifungal Lock Therapy by Li X, Yu B, Li H, Liu Z, Fu X, Jiao P, Wang L

“…Drug Design, Development and Therapy…”
Get full text

Modeling and simulation of distribution and drug resistance of major pathogens in patients with respiratory system infections by Li Yang, Ermin Liang, Yali Gao

“…A mathematical model was developed to simulate the relationship between pathogen distribution and drug resistance. Results The most common pathogens were Streptococcus pneumoniae (30%), Haemophilus influenzae (20%), Pseudomonas aeruginosa (15%), Staphylococcus aureus (10%) and Klebsiella pneumoniae (10%). …”
Get full text

Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

“…Optimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well as antibody and payload delivery in the case of an antibody-drug conjugate (ADC). In the work presented here, molecular docking suggested a suitable paratope combination targeting c-MET, but hydrophobic patches in essential binding regions of one moiety necessitated engineering. …”
Get full text

Chemo-selective modification of cysteine residue: synthesis and application in the discovery of potential drug candidates by Yanyan Liao, Xuefeng Jiang

“…Exploration of Drug Science…”
Get full text

Enhancing Plasticity of the Central Nervous System: Drugs, Stem Cell Therapy, and Neuro-Implants by Alice Le Friec, Anne-Sophie Salabert, Carole Davoust, Boris Demain, Christophe Vieu, Laurence Vaysse, Pierre Payoux, Isabelle Loubinoux

“…Here, we propose a review of novel drug therapies with strong potential in the clinic. …”
Get full text

Expanding the Role of Drug-Coated Balloons in Treating De Novo Coronary Artery Disease by Anna van Veelen, MD, PhD, Bimmer E.P.M. Claessen, MD, PhD

Subjects: “…drug-coated balloon…”
Get full text

Sequential separation of anti-diabetic drugs in the presence of melamine as impurity using chromatographic methods by Maimana A. Magdy, Maha M. Abdelrahman, Doaa G. Mohamed, Amal B. Ahmed

Get full text

Rhodotorula Endogenous Endophthalmitis: A Novel Harbinger of the Injection Drug Epidemic in the United States by Preston M. Luong, Basilio Kalpakian, Lawrence J. Jaeger, Timothy Lahey, Christopher B. Chapman, Michael E. Zegans

“…Endogenous endophthalmitis is a rare but feared infectious ocular complication of injection drug use (IDU). The recent opioid epidemic in the United States threatens to increase the incidence of this disease. …”
Get full text

Targeted therapy: Role of liposome-based drug delivery in advancing oral cancer treatment by Meenakshi Sundari Rajendran, Ponnulakshmi Rajagopal, Selvaraj Jayaraman, Vishnu Priya Veeraraghavan, Rajkumar Prabhakaran, Rathi Muthaiyan Ahalliya

Get full text

Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach by Navid Kashani, Amir Sabbaghian, Fatemeh EmamiPari, Mohammad Khalili Gorjimahalleh, Mahdi Aalikhani

Subjects: Get full text

A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting by Naeem Mubarak, Muhammad Ahsan Waqar, Asad Majeed Khan, Zainab Asif, Aima Subia Alvi, Aqsa Arshad Virk, Sakeena Amir

“…Traditional methods of delivering drugs to the CNS face considerable limitations. Nose-to-brain targeting offers a promising alternative that bypasses the blood-brain barrier (BBB), enabling targeted drug administration to the central nervous system (CNS). …”
Get full text

Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug by Deysiane Oliveira Brandão, Geovani Pereira Guimarães, Ravely Lucena Santos, Fernando José de Lima Ramos Júnior, Karla Monik Alves da Silva, Fabio Santos de Souza, Rui Oliveira Macêdo

“…Analytical methods have been used to aid in the characterization of compounds derived from plant drug extracts and their products. This paper developed a methodological model to evaluate the integrity of the vegetable drug M. charantia in different particle sizes, using different analytical methods. …”
Get full text

Drug screening for ischemic stroke using larvae and adult zebrafish model: a review by Ni Made Dwi Mara Widyani Nayaka, I Ketut Adnyana, Kusnandar Anggadiredja, Indra Wibowo

“…This review is beneficial as a reference for establishing drug screening protocols using the zebrafish IS model.…”
Get full text

Drug Abuse Prevention Among Students In Improving The Lives Meaning Through Counseling Logo by Kadek Suranata

“…Abuse of drugs, psychotropic substances, illegal drugs and other addictive substances (drugs) among teenagers especially students to be a problem from time to time keeps going on and it seems difficult to be finalized. …”
Get full text

Mesenchymal stromal cell exosomes for drug delivery of prostate cancer treatments: a review by Chengran Wang, Yanshuo Feng, Xinao Rong, Jingguo Yan, Baisong Lv, Hongyu Jiang, Lian Duan, Jinlan Jiang

Subjects: Get full text

Laser treatment of drug-induced gingival enlargement: overview of research of the last 50 years by Laurenta Lelia Mihai, Ioanina Parlatescu, Costina Lixandru, Paula Perlea

Subjects: Get full text

Real-world pharmacovigilance study of drug-induced autoimmune hepatitis from the FAERS database by Bu-kun Zhu, Si-ying Chen, Xiang Li, Shu-yun Huang, Zhan-yang Luo, Wei Zhang

Subjects: Get full text

Wernicke encephalopathy in a patient with drug-induced liver failure: a case report by Jiao-Jiao Cao, Jing Li, Yan Cheng, Li-Min Luo, Yang Chen, Chang-Xing Huang, Ye Zhang

Subjects: Get full text

GS-DTA: integrating graph and sequence models for predicting drug-target binding affinity by Junwei Luo, Ziguang Zhu, Zhenhan Xu, Chuanle Xiao, Jingjing Wei, Jiquan Shen

Subjects: “…Drug-target binding affinity…”
Get full text

Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential by Nurhasni Hasan, Maryam Aftab, Muneeb Ullah, Phuong Tram Nguyen, Rina Agustina, Yulia Yusrini Djabir, Theofilus A. Tockary, Satoshi Uchida

Subjects: Get full text