Targeting Toll-Like Receptors for Treatment of SLE by Christopher G. Horton, Zi-jian Pan, A. Darise Farris

“…Since activation of these receptor pathways promotes autoimmune phenotypes, inhibitory drugs that target these pathways constitute important new therapeutic strategies for the treatment of systemic autoimmunity.…”
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Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case by Rıfkı Üçler, Murat Atmaca, Ömer Candar, Murat Alay, Burhan Göy, Erdal Kara, Mahfuz Turan, Yusuf Demir

“…Agranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of methimazole (MMI) treatment is not a usual situation. …”
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Algebraic and topological indices of molecular pathway networks in human cancers by Peter Hinow, Edward A. Rietman, Sara Ibrahim Omar, Jack A. Tuszyński

“…Our results can aide in identification of promising targets for anti-cancer drugs. Beyond that, we provide a unifying framework to study protein-protein interaction networks of families of related diseases (e.g. neurodegenerative diseases, viral diseases, substance abuse disorders).…”
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The interpretation of Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update by LU Yujie, ZHU Siji

“…The new “2022 version Guideline” suggested that the use of BP should be discussed for all postmenopausal patients with early breast cancer who are indicated for adjuvant therapy. Recommended drugs included zoledronate, clodronate, and ibandronate, and the recommended duration of BP was 2-3 years. …”
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Sesquiterpenes α-humulene and β-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells by Ambrož Martin, Šmatová Markéta, Šadibolová Michaela, Pospíšilová Eva, Hadravská Pavlína, Kašparová Michaela, Skarková Veronika Hanušová, Králová Věra, Skálová Lenka

“…The present study is designed to find out if sesquiterpenes, α-humulene (HUM), valencene (VAL), β-caryphyllene-oxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexaneoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. …”
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Herpes zoster after left nephroureterectomy for renal carcinoma: a case report by Yuren Zhang, Jie Li, Qing Ni

“…Renal insufficiency following renal cell carcinoma surgery can be compounded by treatment with nephrotoxic antiviral drugs. There have also been case reports of herpes zoster occurring at the surgical site. …”
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Anti-tumor role and molecular mechanism of vanillic acid by Xunxing Hao, Zhixiao Gao, Mingzhe Hu

“…Furthermore, VA disrupts the cancer cell cycle, arresting most cancer cells at the G1 phase, curtails cell migration, invasion, angiogenesis, and potentiates the therapeutic efficacy of chemotherapeutic drugs, all while minimizing adverse reactions. This paper offers a comprehensive review of VA's anti-tumor effects and underlying mechanisms, aiming to provide some references for scientists and clinical physicians in the research of anti-tumor therapeutic strategies.…”
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Determinants of Noncompliance to Clinic Appointments and Medications among Nigerian Children with Epilepsy: Experience in a Tertiary Health Facility in Enugu, Nigeria by Roland Chidi Ibekwe, Appolos Chidi Ndukuba, Ann Ebele Aronu, Christopher Bismarck Eke, MaryAnn Ugochi Ibekwe, Ngozi Chinyelu Ojinnaka

“…The major reasons given were lack of finance, clashing with school time, and forgetting to take the drugs. Children whose mothers were less educated and unemployed were more likely to miss clinic appointments. …”
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Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva by Qiwen Li, Quan Yuan

“…Therefore, studying the pathological mechanism and developing efficient drugs for FOP are highly demanding. In this issue of EMBO Molecular Medicine, Zhao et al, introduce bone morphogenetic protein 9 (BMP9) as a potential therapeutic target for FOP (Zhao et al, 2024).…”
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Plants from Arid Zones of Mexico: Bioactive Compounds and Potential Use for Food Production by Isabel Márquez-Rangel, Mario Cruz, Alberto A. Neira-Vielma, Sonia N. Ramírez-Barrón, Pedro Aguilar-Zarate, Ruth Belmares

“…This has led to an opportunity to study arid zone plants as food sources that have potential biological activities and improve consumer health. (2) Methods: In this work, we review recent research focused on the traditional use and importance of arid zone plants, their nutritional contribution, and their beneficial effects on health when they are consumed; these effects are primarily because of their antioxidant activity, which inhibits free radicals and contributes to improved nutrition and benefits consumer health. (3) Results: Several plant-based functional food studies have shown that the consumption of bioactive compounds is a complement to drugs for preventing some chronic degenerative diseases, such as gastrointestinal diseases, diabetes, and obesity. (4) Conclusions: Given all of the previously mentioned factors, plants from arid zones are potential sources for obtaining bioactive compounds with low water requirements.…”
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Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota by R. V. Maslennikov, Yu. V. Evsyutina

“…FXR probiotics and agonists are promising drugs for the NAFLD treatment.Conclusion.  In the course of NAFLD, a change in the composition of the intestinal microbiota is observed, which contributes to the development of inflammation in the liver and disrupts the metabolism of bile acids, leading to insulin resistance.…”
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Nanostructured food proteins as efficient systems for the encapsulation of bioactive compounds by Mehdi Mohammadian, Mostafa I. Waly, Maryam Moghadam, Zahra Emam-Djomeh, Maryam Salami, Ali Akbar Moosavi-Movahedi

“…These nanostructured food proteins have been widely used as nanocarriers for the biologically active compounds and drugs. The release of bioactive compounds from nanocarriers depends mainly on pH as well as swelling and the degradation behavior of nanostructure in the simulated physiological conditions. …”
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Noncontiguous Multifocal Spondylodiscitis in 3 Regions of the Spine by Fernando González González, Arturo Aguirre Madrid, Dizán Mendoza Pedroza, Abelardo Loya Solis, Fernando Hernández Aragon, Nadia Karina Portillo Ortiz, Edmundo Berumen Nafarrate

“…Spondylodiscitis is an uncommon infectious disease of the spine, usually presenting in 1 or 2 contiguous levels, associated with risk factors such as diabetes, intravenous drugs, corticosteroids, and invasive procedures. …”
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Emerging Technologies to Control Oocyte Apoptosis Are Finally Treading on Fertile Ground by Jonathan L. Tilly

“…As a consequence, the inappropriate destruction of female germ cells (oocytes) following exposure to chemotherapeutic drugs and radiation is irreparable, often leading to premature menopause and infertility [1]. …”
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Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection by Yasushi Shintani, Yasuko Terao, Hiroyuki Ohta

“…We proposed that hypothermia contributes to protect neuroinflammation, and identified candidate molecules such as MIP-3α and Hsp70 that warrant further investigation as targets for therapeutic drugs acting as “hypothermia-like neuroprotectants.”…”
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Impact of Tat Genetic Variation on HIV-1 Disease by Luna Li, Satinder Dahiya, Sandhya Kortagere, Benjamas Aiamkitsumrit, David Cunningham, Vanessa Pirrone, Michael R. Nonnemacher, Brian Wigdahl

“…Tat as a therapeutic target for anti-HIV drugs has also been discussed.…”
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Therapeutic Implications of PPARγ in Human Osteosarcoma by Eric R. Wagner, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Wenli Zhang, Qiong Shi, Qing Luo, Xiaoji Luo, Bo Liu, Jinyong Luo, Farbod Rastegar, Connie J. He, Yawen Hu, Barrett Boody, Hue H. Luu, Tong-Chuan He, Zhong-Liang Deng, Rex C. Haydon

“…Thus, safe and effective PPAR agonists and/or retinoid derivatives can be then used as adjuvant therapeutic drugs for OS therapy. Furthermore, these agents have the potential to be used as chemopreventive agents for the OS patients who undergo the resection of the primary bone tumors in order to prevent local recurrence and/or distal pulmonary metastasis.…”
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Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions by Rajkamal Kumavat, Vijay Kumar, Rajesh Malhotra, Hemant Pandit, Elena Jones, Frederique Ponchel, Sagarika Biswas

“…Broad validation of novel and clinically applicable biomarkers and their involvement in the pathways are particularly needed for early-stage diagnosis, monitoring disease progression, and severity and examining new drugs to mitigate the effects of this highly prevalent and debilitating condition.…”
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In Vitro Effect of Aqueous Extract and Fraction IV Portion of Ximenia americana Stem Bark on Trypanosoma congolense DNA by Victor Ambrose Maikai, Beatty Viv Maikai, Patricia Ishyaku Kobo

“…Chemically synthesized drugs and medicinal plants have been used in the treatment and control of this disease. …”
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Treatment of Bullous Systemic Lupus Erythematosus by Lihua Duan, Liying Chen, Shan Zhong, Ying Wang, Yan Huang, Yan He, Jie Chen, Guixiu Shi

“…Recently, it has been reported that quite a few cases of BSLE were successfully treated with other immune suppressive drugs. Therefore, a comprehensive review of the treatment of BSLE would be beneficial to cure the disease.…”
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