Adenine, a key player in biology and medicinal chemistry by Fillion, Alexandra, Vichier-Guerre, Sophie, Arimondo, Paola Barbara

“…This review aims to introduce the adenine and discuss adenine-based inhibitors, their design and use for different therapeutic targets through examples of drugs and compounds that reached clinical and preclinical trials.…”
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MicroRNAs in Neurotoxicity by Prameet Kaur, Arunmozhiarasi Armugam, Kandiah Jeyaseelan

“…Neurotoxicity can also be brought about by external agents like drugs and alcohol as well as brain injury with miRNAs playing a pivotal role in diseases. …”
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Reversible Fetal Renal Impairment following Angiotensin Receptor Blocking Treatment during Third Trimester of Pregnancy: Case Report and Review of the Literature by Tal Saar, Lorinne Levitt, Hagai Amsalem

“…This case may help clinicians counsel patients with pregnancies complicated by exposure to these drugs.…”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…Additionally, their potential for immunogenicity has proven to be a challenge to developing safe and reliably efficacious drugs. Our discussion will emphasize immunogenicity in the context of therapeutic proteins, a well-known class of biologics. …”
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Role of the Indian Association of Preventive and Social Medicine (IAPSM) in Combating Antimicrobial Resistance (AMR) by Purushottam Giri, Venkatesh Karthikeyan

“…Antimicrobial Resistance occurs when bacteria, viruses, fungi, and parasites evolve and no longer respond to antimicrobial treatments, rendering these drugs ineffective. This makes infections increasingly difficult, or even impossible, to treat, thereby raising the risk of disease spread, severe illness, disability, and death. …”
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Updates in Refractory Status Epilepticus by Rohit Marawar, Maysaa Basha, Advait Mahulikar, Aaron Desai, Kushak Suchdev, Aashit Shah

“…Management of refractory status epilepticus involves treatment of an underlying etiology in addition to intravenous anesthetics and antiepileptic drugs. Alternative treatment options including diet therapies, electroconvulsive therapy, and surgical resection in case of a focal lesion should be considered. …”
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Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms by Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin

“…The leading compound was significantly less toxic than miramistin and benzalkonium chloride and more toxic than the reference antifungal drugs. The obtained results make the described chemotype a promising starting point for the development of new broad-spectrum antimicrobial therapies with powerful effect on fungal and bacterial pathogens including their biofilm-embedded forms.…”
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Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target by Anna Socha-Banasiak, Patrycja Sputa-Grzegrzółka, Jędrzej Grzegrzółka, Krzysztof Pacześ, Piotr Dzięgiel, Beata Sordyl, Hanna Romanowicz, Elżbieta Czkwianianc

“…In the treatment of patients with Crohn’s disease (CD) and ulcerative colitis (UC), it is increasingly common to use biological drugs that selectively affect individual components of the inflammatory cascade. …”
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The neuroscience in breast cancer: Current insights and clinical opportunities by Jia-feng Wang, Meng-chuan Wang, Lei-lei Jiang, Neng-ming Lin

“…Interaction between the nervous system and breast cancer can influence tumor initiation, growth, invasion, metastasis, reverse resistance to drugs, promote inflammation in tumors, and impair the immune system's ability to combat cancer. …”
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Recurrent Plasmacytomas after Allografting in a Patient with Multiple Myeloma by Allen N. Stawis, Diane Maennle, Moreno Festuccia, Zia Uddin, Benedetto Bruno

“…Extramedullary recurrence in multiple myeloma patients has been reported after both autologous and allogeneic hematopoietic cell transplantation and, more recently, after treatment with so-called new drugs with potent antimyeloma activity. Only a very few sizable reports focused on its clinical presentation and its incidence, which may be highly underestimated, and most observations are based on single patients reported from several institutions. …”
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Multiple Myeloma with Foamy Mott Cells by Karen Nalbandyan, Daniel Benharroch, Benzion Samueli, Michael Kafka, Anna Gourevitch

“…A biopsy performed following initial biological and immunomodulatory drugs revealed different morphological and clonal characteristics. …”
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Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials by Jixin Zhong, Quan Gong, Aditya Goud, Srividya Srinivasamaharaj, Sanjay Rajagopalan

“…DPP4 inhibitors (DPP4i) are a class of newly developed antidiabetic drugs which preserve incretin hormones and promote postprandial insulin secretion. …”
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A mixed methods protocol to investigate medication adherence in patients with rheumatoid arthritis of White British and South Asian origin by Karim Raza, Peter Nightingale, Karen Shaw, Rob Horne, Kanta Kumar, Sheila Greenfield, Paramjit Gill

“…In the context of rheumatoid arthritis, there is a dearth of data on adherence to disease-modifying antirheumatic drugs among minority ethnic groups. This study aims to assess the relationship between adherence to medicines and biopsychosocial variables in patients with rheumatoid arthritis of South Asian and White British origin.Methods/analysis A mixed methods approach will be used, encompassing a cross-sectional survey of 176 patients collecting demographic and clinical data, including information on adherence behaviour collected using a series of questionnaires. …”
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Perinatal Cerebellar Injury in Human and Animal Models by Valerie Biran, Catherine Verney, Donna M. Ferriero

“…The different mechanisms involved have been investigated with animal models and are primarily hypoxia, ischemia, infection, and inflammation Exposure to drugs and undernutrition can also induce cerebellar abnormalities. …”
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Odour generalisation and detection dog training by Lyn Caldicott, Thomas W. Pike, Helen E. Zulch, Daniel S. Mills, Fiona J. Williams, Kevin R. Elliker, Bethany Hutchings, Anna Wilkinson

“…Abstract Detection dogs are required to search for and alert to specific odours of interest, such as drugs, cadavers, disease markers and explosives. …”
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A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis by G. A. C. Gamakaranage, C. Kulathilake, P. G. N. Nadeeshani, K. H. B. P. Fernandopulle, C. S. Moonesinghe, D. Gunawardena, R. S. Gamage, N. Perera, J. Indrakumar

“…The common underlying diseases are autoimmune disorders, malignancies, infections, and drugs. However, approximately 50% of the cases do not have a specific aetiology and about 10% will not have bleeding manifestations. …”
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Anti-HSV-1 agents: an update by Wenwen Lv, Lei Zhou, Jia Wu, Jishuai Cheng, Yongzhong Duan, Wen Qian

“…To date, there are no approved commercially available vaccines, and anti-HSV-1 drugs such as specific or non-specific nucleotide (nucleoside) analogs and helicase-primase inhibitors have become the main clinical agents for the treatment of HSV-1 infections despite challenges from resistance. …”
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A Case of Almost Painless Herpes Zoster Presenting with Symptoms of Cystitis, Penile Numbness, and Acute Vestibular Failure by Hussain Al-Sardar

“…It is more common in older people and individuals with immunocompromised conditions. Antiviral drugs can shorten the duration and the severity of the illness and need to be started as soon as possible after the appearance of the rash. …”
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Retropharyngeal effusion secondary to calcific tendinitis of the longus colli muscle: A case report and brief review of the literature by Musharaf Khan, DO, Subtain Ali, MD, Dhairya A Lakhani, MD

“…In contrast, calcific tendinitis responds well to conservative treatment, including nonsteroidal anti-inflammatory drugs (NSAIDs). Here, we report a case of retropharyngeal effusion secondary to calcific tendinitis of the longus colli muscle, highlighting the importance of distinguishing it from other conditions, such as retropharyngeal abscess, to avoid unnecessary invasive treatments.…”
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Tissue Engineered Strategies for Skeletal Muscle Injury by Umile Giuseppe Longo, Mattia Loppini, Alessandra Berton, Filippo Spiezia, Nicola Maffulli, Vincenzo Denaro

“…Current therapy consists of conservative management including RICE protocol (rest, ice, compression, and elevation), nonsteroidal anti-inflammatory drugs, and intramuscular corticosteroids. However, current management of muscle injuries often does not provide optimal restoration to preinjury status. …”
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