Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides by Lucia Vrablova, Tomas Gonec, Tereza Kauerova, Michal Oravec, Izabela Jendrzejewska, Peter Kollar, Alois Cizek, Josef Jampilek

“…Key results: Three compounds showed activity comparable to clinically used drugs. N-(3,5-Dimethylphenyl)-2-hydroxynaphthalene-1-carboxamide (13) showed only anti¬sta¬phylococcal activity (minimum inhibitory concentration (MIC) = 54.9 µM); 2-hydroxy-N-[2-methyl-5-(tri¬fluoro¬methyl)phenyl]naphthalene-1-carboxamide (22) and 2-hydroxy-N-[4-nitro-3-(trifluoromethyl)phe¬nyl]na¬phtha¬lene-1-carboxamide (27) were active across the entire spectrum of tested bacteria/mycobacteria, both against the sensitive set and against resistant isolates (MICs range 0.3 to 92.6 µM). …”
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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

“…Despite the success of these drugs, a substantial proportion of patients do not benefit. …”
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The Antibiotic Puzzle: Guidelines for the Family Physician by G Harding, S Field, R MacMahon, T Louie, Prairie Consensus Conference Group

“…Choosing the most appropriate antibiotic for the treatment of common infections is becoming increasingly complex. New drugs and new classes of antibiotics are being developed and made available, and emerging resistance and pharmacoeconomics play important roles. …”
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Constipation treatment safety at pregnancy by O. Z. Okhlobystina

“…However, if sure nutrition, keeping of proper lifestyle and moderate physical activity do not result in desirable effect, drugs should be prescribed. Macrogol 4000 is effective and safe at pregnancy even at long-term intake.…”
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Illegal cannabis cultivation in Europe: new developments by David Weinberger, Michel Gandilhon, Jalpa Shah, Nacer Lalam

“…Herbal cannabis is one of the most consumed illegal drugs in Europe, with increasing local production. …”
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Synthesis and Characterization of Boron Trifluoride Doped High Performance Polyaniline by K. Basavaiah, D. Samsonu, A. V. Prasada Rao

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Managing Cancer Pain - Simple Rules, Major Benefits by Dwight E Moulin

“…Mild pain can be treated with acetaminophen or nonsteroidal anti-inflammatory drugs (Step 1 of the analgesic ladder). Moderate pain requires the addition of a 'minor' opioid such as codeine (Step 2), and severe pain mandates the use of a major opioid analgesic such as morphine (Step 3). …”
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The Enteric Nervous System in Intestinal Inflammation by Keith A Sharkey, Edward J Parr

“…Finally, it appears that the enteric nervous system may be a potential therapeutic target in IBD and that neuroactive drugs acting locally can represent useful agents in the management of this disease.…”
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Motion – Laparoscopic Nissen Fundoplication Is More Cost Effective Than Oral PPI Administration: Arguments for the Motion by Lee L Swanström

“…The effectiveness of treatment also depends on patient-related factors, including weight, socioeconomic factors, smoking, alcohol use, dietary habits and the use of nonsteroidal anti-inflammatory drugs. Surgical results depend on the experience and skill of the surgeon, as well as the attributes of the institution in which the procedure is undertaken. …”
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Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography by Andrzej Czyrski

“…The lipophilicity is an important parameter that influences the activity of the drugs in the human body. The reversed phase high performance thin layer chromatography was applied to determine the Log P values of ibuprofen, ketoprofen, naproxen, and flurbiprofen. …”
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Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer by Helmut Bonkhoff

“…Some of these markers have the promise to be targeted by drugs currently available to enhance the efficacy of RT and delay disease progression.…”
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Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review by Lavanya Mallika, Mani Rajarathinam, Sundararajan Thangavel

“…These stem cells possess several features like slow cell cycle, ability to extrude chemotherapeutic drugs, exhibit epithelial mesenchymal transition, and inhibit apoptosis. …”
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Facile Synthesis of Propranolol and Novel Derivatives by Vy Anh Tran, Nguyen Hai Tai Tran, Long Giang Bach, Trinh Duy Nguyen, Thi Thuong Nguyen, Tan Tai Nguyen, Thi Anh Nga Nguyen, The Ky Vo, Thu-Thao Thi Vo, Van Thuan Le

“…Propranolol is one of the first medications of the beta-blocker used for antihypertensive drugs. This study reports the facile route for the synthesis of propranolol and its novel derivatives. …”
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Advances in Immunotherapy for Melanoma: A Comprehensive Review by Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Adriana López-Barcenas, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Roberto Arenas Guzman

“…These treatments have the same goal as drugs that are already used to stimulate the proliferation of T lymphocytes in order to destroy tumor cells; however, immunotherapies aim to selectively attack the tumor cells of each patient. …”
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Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines by Mervin Chávez-Castillo, Victoria Núñez, Manuel Nava, Ángel Ortega, Milagros Rojas, Valmore Bermúdez, Joselyn Rojas-Quintero

“…Currently available antidepressant drugs are notoriously problematic, with suboptimal remission rates and troubling side-effect profiles. …”
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Empyema Necessitans Complicating Pleural Effusion Associated with Proteus Species Infection: A Diagnostic Dilemma by M. S. Yauba, H. Ahmed, I. A. Imoudu, M. O. Yusuf, H. U. Makarfi

“…This case was treated with quinolones, antituberculous drugs, chest tube drainage, and nutritional rehabilitation. …”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…This review explores the etiology, mechanisms, and pathophysiology of RVF, drugs directly targeting the RV myocardium, the intricate biological processes between RV and pulmonary vascular remodeling, surgical and device therapies, and future perspectives on managing RVF.…”
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Anti-CD20 Treatment of Autoimmune Hemolytic Anemia Refractory to Corticosteroids and Azathioprine: A Pediatric Case Report and Mini Review by Alexandros Makis, Zoi Kanta, Dimitrios Kalogeropoulos, Nikoloaos Chaliasos

“…Refractory cases are treated with immunosuppressive drugs, cytotoxic agents, androgens, or splenectomy, with various side effects and questionable efficacy. …”
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Iron Deficiency Anaemia Caused by Nonspecific (Idiopathic) Small Bowel Ulceration: An Uncommon Presentation of an Uncommon Disease by Gabriele Capurso, Edith Lahner, Nadia Pallotta, Francesco Panzuto, Gianfranco Delle Fave, Bruno Annibale

“…Ulcers of the small bowel are rare, and in most cases are due to infections, inflammatory bowel diseases, malignancies or drugs. When none of these causes is recognized, they are classified as ‘nonspecific’ or idiopathic. …”
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Current Status of New Anticoagulants in the Management of Venous Thromboembolism by Roberto C. Montoya, Ajeet Gajra

“…Despite their broad use, these agents have important limitations that have led to the development of new drugs in a bid to overcome the disadvantages of the old ones without decreasing their therapeutic effect. …”
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