Synthesis and Antitubercular Activity of Heteroaromatic Isonicotinoyl and 7-Chloro-4-Quinolinyl Hydrazone Derivatives by Marcelle de L. Ferreira, Raoni S.B. Gonçalves, Laura N. de F. Cardoso, Carlos R. Kaiser, Andre L.P. Candéa, Maria das Graças M. de O. Henriques, Maria C.S. Lourenço, Flávio A.F.M. Bezerra, Marcus V. N. de Souza

“…Several compounds were noncytotoxic and exhibited significant minimum inhibitory concentration (MIC) activity (3.12, 2.50, 1.25, or 0.60 μg/mL), which can be compared to that of the first-line drugs ethambutol (3.12 μg/mL) and rifampicin (2.0 μg/ml). …”
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Efficacy of silymarinum at chronic diffuse liver diseases by A. V. Matvieiev, E. I. Konyaeva, N. V. Matvieieva

“…Analysis of literary data demonstrated, that silymarinum is a safe pharmaceutical and, despite of a plenty of clinical and experimental publications, its efficacy at alcoholic liver disease and primary biliary cirrhosis requires further studying as series of systematic reviews and metaanalyses are subject for discussion due to the absence of uniform methodological approaches, application of drugs with different pharmakokinetics and because of ignoring of evidencebased medicine requirements.Conclusion. …”
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Effective anti-adhesives of uropathogenic Escherichia coli by Ribić Rosana, Meštrović Tomislav, Neuberg Marijana, Kozina Goran

“…Design of receptor analogues that competitively bind to UPEC surface adhesins placed at the top of pili organelles led to the development of anti-adhesive drugs that are increasingly recognized as important and promising alternatives to antibiotic treatment of UTIs.…”
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Pulmonary Alveolar Microlithiasis and Rheumatoid Arthritis: A Case Report and Review of the Literature by Waleed Hafiz, Ahmedhusam Alahmed, Mohammed Alahmadi, Rakan Alotaibi, Abdullah Alsharif, Safwan Alim, Mohammed Mokhtar, Kholoud Al-Maabdi, Omaima Badr

“…It targets the lining of the synovial membranes, frequently affects females more than males, and is treated with the disease-modifying antirheumatic drugs (DMARDs). If left untreated, it leads to increased morbidity, mortality, and socioeconomic burdens. …”
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Renin-Angiotensin System Inhibitors in COVID-19: Current Concepts by Kunal Mahajan, Prakash Chand Negi, Neeraj Ganju, Sachin Sondhi, Naresh Gaur, Rao Somendra

“…Some researchers have questioned RAS inhibitors’ safety in COVID-19 patients since these drugs have demonstrated an increase in ACE-2 expression in preclinical studies; therefore, they may facilitate viral invasion. …”
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Mixed Fungal Infection (Aspergillus, Mucor, and Candida) of Severe Hand Injury by Milana Obradovic-Tomasev, Aleksandra Popovic, Nada Vuckovic, Mladen Jovanovic

“…The treatment was conducted with repeated surgical necrectomy and administration of antifungal drugs according to the antimycogram. After ten weeks the patient was successfully cured. …”
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Epidemiology of Kidney Cancer by D. Pascual, A. Borque

“…Viral infections and radiation therapy have also been described as risk factors. Some drugs can increase the incidence of RCC as well as other neoplasms. …”
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Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells by J. I. Raji, C. K. Onwuamah, P. G. C. Odeigah

“…Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell. …”
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Peritoneal Dialysis in Diabetics: There Is Room for More by P. Cotovio, A. Rocha, A. Rodrigues

“…Nutritional evaluation and support, preferential use of low-glucose degradation products solutions, and prescription of renin-angiotensin-aldosterone system acting drugs should also be part of the panel to improve diabetic care under peritoneal dialysis.…”
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Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes by Mikhail V. Pugachev, Thang T. N. Nguyen, Timur M. Bulatov, Roman S. Pavelyev, Alfia G. Iksanova, Oksana V. Bondar, Konstantin V. Balakin, Yurii G. Shtyrlin

“…A series of trans-6-phenylethenyl substituted pyridoxine derivatives, novel bioisosteric analogs of drugs based on trans-stilbene scaffold, were synthesized using the Wittig reaction of a bis-triphenylphosphonium pyridoxine derivative with various aromatic aldehydes. …”
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Kaposi´s sarcoma, epidemic type. Case presentation by Gilberto Serrano Ocaña, Juan Carlos Ortiz Sablon, Ilen Ochoa Tamayo

“…It affects approximately 20% of people with HIV that don’t take antiretroviral drugs. It is more common in homosexual’s patients, but may appear in any HIV positive individual, in Africa where heterosexual HIV transmission route is the most important can also be found in children and women. …”
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Sympathetic Renal Innervation and Resistant Hypertension by Vito M. Campese, Elaine Ku, Jeanie Park

“…Recognition of this important pathogenic factor suggests that antiadrenergic drugs should be an essential component to the management of hypertension in patients with kidney disease, particularly those who are resistant to other modalities of therapy.…”
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Interferon-free therapy of chronic hepatitis C: replacement of medications or new treatment paradigm? by S. N. Batskikh

“…Interferon-free variants of CHC treatment have certain advantages over modes of interferon-α based treatment. Monotherapy by drugs with direct action on virus is less effective in comparison to combined application. …”
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AAV-based vectors for human diseases modeling in laboratory animals by Timur I. Aliev, Dmitry V. Yudkin

“…The development of therapeutic drugs and vaccines requires the availability of appropriate model animals that replicate the pathogenesis of human diseases. …”
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1,10-Phenanthroline and 4,5-Diazafluorene Ketones and Their Silver(I) and Platinum(II) Complexes: Syntheses and Biological Evaluation as Antiproliferative Agents by Leonardo Sandin-Mazzondo, Jesús M. Martínez-Ilarduya, Jesús A. Miguel, Camino Bartolomé, Concepción Alonso

“…Complexes <b>3Ag</b> and <b>1Pt</b> showed an acceptable SI and better selectivity than cisplatin, proving that silver(I) complexes and Pt(polyfluorophenyl) complexes are valuable options in searching for new antitumoral drugs.…”
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Polydomus karssenii gen. nov. sp. nov. is a dark septate endophyte with a bifunctional lifestyle parasitising eggs of plant parasitic cyst nematodes (Heterodera spp.) by Samad Ashrafi, Jan-Peer Wennrich, Yvonne Becker, Jose G. Maciá-Vicente, Anke Brißke-Rode, Matthias Daub, Torsten Thünen, Abdelfattah A. Dababat, Maria R. Finckh, Marc Stadler, Wolfgang Maier

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The absorption kinetics of Antarctic krill oil phospholipid liposome in blood and the digestive tract of healthy mice by single gavage by Lin Li, Chengcheng Wang, Shan Jiang, Rong Li, Tiantian Zhang, Changhu Xue, Teruyoshi Yanagita, Xiaoming Jiang, Yuming Wang

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Clinical Features, Risk Factors, and Therapy of Epithelial Keratitis after Cataract Surgery by Yani Wang, Dongfang Li, Wenjie Su, Yunhai Dai

“…Attention should be paid to the tear film function and use of topical nonsteroidal anti-inflammatory drugs in patients undergoing cataract surgery.…”
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Insights into the Mode of Action of Novel Morpholinated Curcumin Derivatives Exhibiting Potent Antitumor Activity in Bladder Cancer Cells In Vitro by Paulina Kobylka, Pawel Bakun, Joanna Kuzminska, Tomasz Goslinski, Marek Murias, Malgorzata Kucinska

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Blood pressure control with active ultrafiltration measures and without antihypertensives is essential for survival in hemodiafiltration and hemodialysis programs for patients with... by Franklin Geovany Mora-Bravo, Pamela Tatiana Morales Torres, Nelson Rojas Campoverde, Guillermina Lucía Blum Carcelen, Juan Cristobal Santacruz Mancheno, Ángel Cristóbal Santacruz Tipanta, Hector Perez-Grovas, Willan Patricio Robles Abarca

“…In Group 2, patients who required antihypertensive drugs for not meeting the aims of systolic blood pressure were included. …”
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