Control of atropoisomerism: an access to valuable compounds by Choppin, Sabine, Wencel-Delord, Joanna, Colobert, Françoise

“…Atropoisomerism is well-known in biaryls, however this phenomenon is encountered in many pharmaceutically relevant compounds such as heterobiaryl, diarylamines, benzamides and anilides.Currently four FDA-approved drugs are atropostable and many others are in clinical trials. …”
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Review of Rome-IV criteria for the irritable bowel syndrome: are there any basic changes? by A. A. Sheptulin, M. A. Vize-Khripunova

“…It causes the need of the limited laboratory and instrumental investigation of the patients. The new drugs (rifaximin, lubiprostone, linaclotide etc.) are included in the treatment modes. …”
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Thiazolidinediones on PPARγ: The Roles in Bone Remodeling by Wei Wei, Yihong Wan

“…Thiazolidinediones (TZDs) are synthetic PPARγ (peroxisome proliferator-activated receptor gamma) agonists and a class of drugs for diabetes mellitus type 2 that can decrease blood sugar efficiently by enhancing insulin sensitivity. …”
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Hot pants: The emerging field of exercise mimetics, from hospital beds to the international space station by Kevin John

“…A relevant and current example of this is the enormous market demand for glucagon‐like peptide‐1 drugs for the management of obesity and type‐2 diabetes. …”
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Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases by Parama Dey, Anup Singhania, Ajaikumar B. Kunnumakkara, Subrata Ghosh, Anirban Bandyopadhyay

“…Conventional cancer drugs are small molecules that target specific pathways. …”
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Polyporus umbellatus, A Precious Rare Fungus With Good Pharmaceutical and Food Value by Sizhu Ren, Hua Liu, Qing Sang, Yifan Sun, Liyan Li, Wenjie Chen

“…Particularly, due to its diuretic properties, it is considered an important source of targeted drugs for the treatment of kidney disease. Extensive research has been conducted on this fungus, focusing not only on its challenging cultivation techniques but also on its diverse array of medicinal ingredients, including polysaccharides and steroids. …”
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Peri-Ictal and Ictal Cognitive Dysfunction in Epilepsy by Lavanya Vijayaraghavan, Subbulakshmy Natarajan, Ennapadam Srinivas Krishnamoorthy

“…Factors contributing to cognitive dysfunction are the type of epilepsy, type and frequency of seizures, anti-epileptic drugs and the location of underlying brain lesions. …”
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Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding by Meiting Shi, Lu Sun, Jiachun Wei, Yao Shen, Jian Wang, Ping Zhang, Xiaofeng Yang, Yuzhen Ding, Wanchang Yin, Xinyao Lu, Xuesong Yang, Guang Wang, Ruiman Li

“…Given the limitations on medication use during pregnancy, exploring natural, safe, and effective drugs for PE is worthwhile. We investigate the causal relationship between ferroptosis, inflammation, and PE, and determine the protective effects of quercetin (QCT), a representative compound that is classified as a flavanol, against endothelial dysfunction. …”
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Alcoholism and Inflammatory Response: Implications for Liver and Cardiovascular Disease by Christian Gabriel Acosta Ricachi, Sheila Ivette Quinapanta Serrano, Álvaro Paúl Moina Veloz

“…Alcohol is one of the main drugs consumed in the history of mankind. Prevention of irresponsible alcohol consumption is currently a priority in the health sector. …”
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Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of <i>Candida albicans</i> Biofilms by Muhammad Aamir Hassan, Sadaf Noor, Jungmi Park, Ahmed Nabawy, Maitri Dedhiya, Robin Patel, Vincent M. Rotello

“…<i>Candida albicans</i> is a particularly widespread pathogen, with both molecular and biofilm-based mechanisms making it resistant to or tolerant of available antifungal drugs. This study reports a combination therapy, active against <i>C. albicans</i>, utilizing terbinafine and essential oils incorporated into a gelatin-based nanoemulsion system (T-GNE). …”
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Modern Approaches to Vaccination of Patients with Chronic Liver Diseases and Inflammatory Bowel Diseases against a Novel Coronavirus Infection by A. A. Sheptulin, V. T. Ivashkin

“…IBD patients are also subject to vaccination, although the immunomodulatory drugs which they take may reduce its effectiveness. …”
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Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process by Kevin Tatoueix, Marco Lepron, Cédric Barboux, Marie-Christine Scherrmann, Grégory Pieters, Sophie Feuillastre

“…Abstract Labelled compounds bearing hydrogen isotopes are keystones in diverse areas constituting a multi-billion dollar global market including drugs, diagnostics, biology, toxicology and smart materials. …”
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Quasi-Complete Response of Classic Kaposi’s Sarcoma Treated with Weekly Paclitaxel by Zineb Benbrahim, Samia Arifi, Hafida Benhammane, Kaoutar Inani, Salim Gallouj, Meriem Meziane, Fatima Zahra Mernissi, Nawfel Mellas, Omar El Mesbahi

“…Patients with extensive KS can be treated with systemic chemotherapy. A number of drugs approved for treatment of AIDS-associated KS, especially Paclitaxel, have activity against CKS after failure of prior therapy. …”
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The Need for Pediatric Formulations to Treat Children with HIV by Adrienne F. Schlatter, Andrew R. Deathe, Rachel C. Vreeman

“…Important causes of poor adherence are formulation- and regimen-specific properties, including poor palatability, large pill burden, short dosing intervals, and the complex storage and transportation of drugs. This review aims to summarize the various regimen- and formulation-based barriers to ART adherence among children to support the need for new and innovative pediatric formulations for antiretroviral therapy (ART). …”
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Successful Treatment of Opioid Dependence with Flexible Doses of Injectable Prolonged Release Buprenorphine by Oscar D’Agnone

“…Adoption of the injectable form was clinically successful with no withdrawal signs, nor evidence of use of other drugs. Patient reported outcomes were positive including reduction in cravings and anxiety and improved attitude, relationships, and general mood.…”
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A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR) by Mahrokh Marzi, Mojtaba Farjam, Zahra Kazeminejad, Abolfazl Shiroudi, Amin Kouhpayeh, Elham Zarenezhad

“…Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. …”
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Laparoscopic Sleeve Gastrectomy in a Morbidly Obese Patient with Myasthenia Gravis: A Review of the Management by Megana Ballal, Tracey Straker

“…Therefore, we can minimize perioperative risks and complications by adjusting the anesthetic plan based on the patient’s physiology and comorbidities as well as the pharmacology of the drugs.…”
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Cervical Lymph Node Metastasis in Chromophobe Renal Cell Carcinoma: A Case Report and Review of the Literature by Noureddine Bouadel, Fahd El Ayoubi, A. Anass Bennani-Baiti, Mohamed Anas Benbouzid, Leila Essakalli, Mohammed Kzadri, Ali El Ayoubi

“…The patient was successfully treated by surgery and antiangiogenic drugs with stabilization and no recurrence of the metastatic disease. …”
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Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture by Xi Sun, Qi Guo, Wenhua Wei, Stephen Robertson, Ying Yuan, Xianghang Luo

“…Appropriate chemical modifications and delivery vectors, which improve the biological performance and potency of microRNA-based drugs, hold the key to translating miRNA technologies into clinical practice. …”
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Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination by Marta Rodrigues de Carvalho, Myrian Mathildes Sá de Deus Rocha, Vinícius Alves Bezerra, Maciel Eduardo de Pontes, Maria Cristina del Negro, Julio Salgado Antunes, Vinícius Viana Abreu Montanaro, Rubens Nelson Morato Fernandez

“…The diagnosis of probable post-vaccination IMNM was made due to the absence of other factors that may have led to the development of autoantibodies (medicines; e.g., statins, drugs) and the temporal relationship between exposure and event. …”
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