Dysphagia due to Diffuse Idiopathic Skeletal Hyperostosis by Masafumi Ohki

“…His symptoms were relieved by conservative therapy using anti-inflammatory drugs. However, if conservative therapy fails and symptoms are severe, surgical treatments must be considered.…”
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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…In this study, a series of bis(7)-harmine derivatives were designed and synthesized as multifunctional drugs for the treatment of AD.MethodsThe derivatives were synthesized by chemical methods and their structure was confirmed by nuclear magnetic resonance (NMR). …”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Consequently, there is significant in discovering new drugs that have minimal side effects and a pronounced hypoglycemic effect. …”
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WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…The power of a tumor-associated-antigen (TAA)-derived cancer vaccine may be enhanced in combination with stronger adjuvants, helper peptide, molecular-target-based drugs, or some chemotherapy drugs, such as gemcitabine, which has been revealed to suppress regulartory T-cell function. …”
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Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway by Qingwen Zhang, Jinxia Sun, Yan Fu, Weigang He, Yinhong Li, Hongsheng Tan, Hongxi Xu, Xin Jiang

“…The current tuberculosis (TB) control is facing the challenge of drugs deficiency, especially in the context of increasingly multidrug resistant (MDR) TB. …”
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Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis by Feng Sun, Sanbao Chai, Lishi Li, Kai Yu, Zhirong Yang, Shanshan Wu, Yuan Zhang, Linong Ji, Siyan Zhan

“…Our results suggest GLP-1 RAs are promising candidates for weight control in comparison with traditional hypoglycemic drugs, and EX10BID, LIR1.8QD, and EX2QW rank the top three drugs.…”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Proof-of-concept experiments revealed that convenient and quantitative monitoring of viral infection and replication is possible with this system, allowing for the evaluation of antiviral drugs and neutralizing antibodies.…”
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Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation by Brittany Miles, Muhammad Mujtaba, Shehzad Merwat, Rupak Kulkarni, Jeffrey Fair, Michael Kueht

“…Identification of the underlying cause and the use of antiepileptic drugs (AEDs) is crucial for minimizing risk to the patient’s neurologic and overall health. …”
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Potential of the Essential Oil from Pimenta Pseudocaryophyllus as an Antimicrobial Agent by Suzuki Érika Yoko, Baptista Edilene Bolutari, Resende Do Carmo Antônio Márcio, Miranda Chaves Maria Das Graças Afonso, Chicourel Elizabeth Lemos, Barbosa Raposo Nádia Rezende

“…Scanning electron microscope (SEM) observations confirmed the physical damage and morphological alteration of the test bacteria treated with the essential oil, reference drugs and eugenol. The findings of the study demonstrated that this essential oil can be used in the formulation of personal care products.…”
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Transgenic Killer Commensal Bacteria as Mucosal Protectants by Luciano Polonelli

“…Unfortunately, current strategies for mucosal protection against candidiasis are severely limited by the lack of effective vaccines and the relative paucity and toxicity of commercially available antifungal drugs. An additional option has been reported in a recent…”
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In Vitro Assay to Examine Osteoclast Resorptive Activity Under Estrogen Withdrawal by Cara Fiorino, Safia Omer, Nisha Gandhi, Rene Harrison

“…This simple and robust model can also be adapted to examine the effect of drugs and genetic factors influencing OC resorptive activity in addition to being compatible with fluorescent imaging.…”
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Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives by Mohamed S. Mostafa, Nasser M. Abd El-Salam, Othman Y. Alothman

“…The synthesized products were tested against B. subtilis, S. aureus, and E. coli as well as C. albicans compared with tetracycline and nystatin as reference drugs.…”
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Prevention and management of minor complications in percutaneous endoscopic gastrostomy by Kurt Boeykens, Ivo Duysburgh, Wim Verlinden

“…These tubes are placed through the abdominal wall mainly to administer fluids, drugs and/or enteral nutrition but can also be used for drainage or decompression. …”
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Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1 by Grzegorz Piecha, Jerzy Chudek, Andrzej Więcek

“…It also summarises the recent advances in the pharmacological therapy with a new group of drugs—calcimimetics.…”
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Therapeutic Improvement of Scarring: Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments by Nick L. Occleston, Anthony D. Metcalfe, Adam Boanas, Nicholas J. Burgoyne, Kerry Nield, Sharon O'Kane, Mark W. J. Ferguson

“…Existing treatments are unreliable and unpredictable and there are no prescription drugs for the prevention or treatment of dermal scarring. …”
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Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives by Selvaraj Jubie, Rajamanickam Gayathri, Rajagopal Kalirajan

“…Ethidium bromide induction showed muscle weakness; muscle discoordination; loss of locomotor activity, and so forth, the synthesized drugs reversed all the above-mentioned neuromuscular disorders caused by ethidium bromide administration.…”
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NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics by Yuzhou Liu, Ying Wang, Ping Yan, Ning Cui, Kejin Xu, Da Liu, Yuan Tian, Lingling Cao

“…The most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course of OA. …”
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Nephrotic Syndrome in Children: From Bench to Treatment by J.-C. Davin, N. W. Rutjes

“…Fifty percents of the latter recur frequently and necessitate a prevention of relapses by nonsteroid drugs. On the contrary to SSINS, steroid resistant nephrotic syndrome (SRINS) leads often to end-stage renal failure. …”
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Case of Cardiac Arrest Treated with Extra-Corporeal Life Support after MDMA Intoxication by Pierre Voizeux, Romain Lewandowski, Theresa Daily, Omar Ellouze, Olivier Bouchot, Belaïd Bouhemad, Pierre-Grégoire Guinot

“…We implemented extra-corporeal life support combined with vasoactive drugs. Later, he also benefited from renal replacement therapy and mechanical ventilation. …”
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The PPARγ Agonist Rosiglitazone Is Antifibrotic for Scleroderma Lung Fibroblasts: Mechanisms of Action and Differential Racial Effects by Galina S. Bogatkevich, Kristin B. Highland, Tanjina Akter, Richard M. Silver

“…We conclude that PPARγ agonists warrant consideration as potential antifibrotic drugs in patients with SSc-ILD. Differential therapeutic effects might be anticipated especially relative to racial differences and the functional expression of the c-Met receptor.…”
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