The role of TNF-α inhibitor in glioma virotherapy: A mathematical model by Elzbieta Ratajczyk, Urszula Ledzewicz, Maciej Leszczynski, Avner Friedman

“…We study the efficacy of the treatment under different combinations of the two drugs for different scenarios of the burst size of newly formed virus emerging from dying infected cancer cells. …”
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Desmoplasia in Pancreatic Cancer. Can We Fight It? by E. E. Merika, K. N. Syrigos, M. W. Saif

“…Herein we discuss such new developments to fight the desmoplastic reaction, including inhibitors of the epidermal growth factor, fibroblast growth factor, the hedgehog pathway, as well as new molecular targets like CD40 agonist and its effects on T cells, extracellular matrix modifying enzymes such as LOXL2 inhibitor and novel tumour penetrating peptides for delivery of drugs.…”
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Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources by Xiaolong Ji, Jianhang Guo, Tengzheng Cao, Tingting Zhang, Yanqi Liu, Yizhe Yan

“…The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect. However, polysaccharides mainly extracted from natural resources, have advantages of safety, accessibility, and anti-diabetic potential. …”
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Radiation Recall Dermatitis following Radioactive Iodine Therapy: A New Observation by Ikechukwu Chidobem, Tahereh Orouji Jokar, Chisom Mgbodile, Francis Mgbodile, Ghassan Bassil, Nazia Khan

“…Subsequent reports in the literature have associated it with the administration of other drugs, mostly chemotherapy. To our knowledge, this is the first reported case of RRD following radioactive iodine therapy.…”
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A Case of Hypocalcemia with Severe Vitamin D Deficiency following Treatment for Graves’ Disease with Methimazole by Kazuyuki Miyashita, Tetsuyuki Yasuda, Hideaki Kaneto, Akio Kuroda, Tetsuhiro Kitamura, Michio Otsuki, Yasuyuki Okamoto, Noboru Hamada, Munehide Matsuhisa, Iichiro Shimomura

“…Taken together, this case suggests that we should take more care in calcium kinetics and vitamin D status during treatment for Graves’ disease with antithyroid drugs.…”
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NSAIDs and Triptans – a (not) New Treatment Option for Migraine by B. Kakta, Rasa Mameniškienė

“…Non-steroidal anti-inflammatory drugs and triptans are first line treatment of a migraine attack. …”
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Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation by T. Van Genechten, J. van Heerden, T. Bauters, C. Dhooge

“…Therapy with standard of care antiviral drugs, for example Cidofovir, is expensive, requires prolonged administration, and has unfavorable toxicity profiles. …”
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Super-enhancers in tumors: unraveling recent advances in their role in Oncogenesis and the emergence of targeted therapies by Yumeng Ji, Baixue Li, Rongjin Lin, Jing Yuan, Yang Han, Yuping Du, Yang Zhao

“…Furthermore, we discuss the current landscape and challenges in developing cancer therapeutic drugs that target super enhancers.…”
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Cannabinoids and the endocannabinoid system in liver diseases by Anna Parfieniuk-Kowerda, Diana Martonik, Aleksandra Andrzejuk, Aleksander Tarasik, Robert Flisiak

“…It seems that interference in endocannabinoid transmission may serve as an attractive target for the development of hepatological drugs.…”
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“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates) by Manouchehr Mamaghani, Nosrat O. Mahmoodi, Farhad Shirini, Abbas Azimi-Roshan, Azam Monfared

“…An expeditious, efficient, and ecofriendly ultrasound-promoted synthesis of a series of novel 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di(alkanoate and benzoate) derivatives (6a–k), as useful building block candidates for natural products and drugs, is reported. The target compounds were prepared by the reaction of alkyl or aryl carboxylic acid, various bisaldehydes and isocyanocyclohexane in water using one-pot isocyanide-based multicomponent approach. …”
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Homeostatic T Cell Proliferation after Islet Transplantation by Paolo Monti, Lorenzo Piemonti

“…Homeostatic T cell proliferation is mainly driven by the IL-7/IL-7 receptor axis, a molecular pathway which is not affected by standard immune-suppressive drugs and, consequently, represents a novel potential target for immuno-modulatory strategies. …”
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Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation by Chang Liu, Miao Wang, Changli Xu, Bo Li, Juxiang Chen, Jianchun Chen, Zhiwei Wang

“…Immune checkpoint inhibitors are the most commonly used immunotherapy drugs currently. In this review, the characteristics and interaction of bone metastases and their immune microenvironment were systematically discussed, and the relevant research progress of the immunological mechanism of tumor bone metastasis was reviewed. …”
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Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy by Songyan Wang, Bing Li, Chunguang Li, Wenpeng Cui, Lining Miao

“…Up to date, there are also many drugs or agents which have been shown for their protective effects against DN via different mechanisms. …”
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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…English Abstract: Introduction-Faced with the COVID-19 pandemic, and in the absence of an effective andsafe treatment,many drugs were used without medical advice.This study aimed to evaluate the­practices of dispensing non-prescription drugs in three cities in western Algeria. …”
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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…English Abstract: Introduction-Faced with the COVID-19 pandemic, and in the absence of an effective andsafe treatment,many drugs were used without medical advice.This study aimed to evaluate the­practices of dispensing non-prescription drugs in three cities in western Algeria. …”
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Prevalence and Antimicrobial Susceptibility of Bacterial Uropathogens Isolated from Pediatric Patients at Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia by Yamirot Merga Duffa, Kumera Terfa Kitila, Dereje Mamuye Gebretsadik, Adane Bitew

“…Multidrug resistance to two or more drugs was observed in 73.7% of the bacterial isolates. …”
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MODERN TREATMENT OF METASTATIC MELANOMA: FROM STANDARDS TO AN INDIVIDUALIZED APPROACH IN REAL CLINICAL PRACTICE by N. V. Zhukova, R. V. Orlova, N. Yu. Antimonik, S. I. Kutukova, N. P. Belyak, N. V. Popova, S. P. Erdniev

“…That is why the possibility of using modern drugs in real clinical practice for the treatment of this cohort of patients is an urgent issue of modern clinical oncology. …”
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Risk factors for early periventricular intraventricular hemorrhage in extremely low birth weight infants: a retrospective study by Yueju Cai, Yongjiang Jiang, Ping Wang, Xiaopeng Zhao, Yanyan Song, Xiaolan Li

“…The use of vasoactive drugs and prolonged invasive ventilation are associated with increased risk, highlighting the need for careful management of respiratory and hemodynamic support in these infants.…”
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Validated HPLC method for simultaneous determination of azelastine hydrochloride fluticasone propionate and oxymetazoline in nasal mucosa and nasopharyngeal swabs from real human s... by Neven N. Mikawy, Nancy Magdy, Marwa H. Mohamed, Amira M. El-Kosasy

“…Abstract A combination of three co-administrated drugs, such as azelastine hydrochloride (AZT), fluticasone propionate (FP), and oxymetazoline (OXY), is more effective than single therapy for the treatment of seasonal allergy and COVID-19. …”
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Isolation and Identification of Staphylococcus aureus from Milk and Milk Products, Associated Factors for Contamination, and Their Antibiogram in Holeta, Central Ethiopia by Endrias Zewdu Gebremedhin, Addisu Bedashu Ararso, Bizunesh Mideksa Borana, Kebede Abdisa Kelbesa, Nega Desalegn Tadese, Lencho Megersa Marami, Edilu Jorga Sarba

“…Good hygienic practices, regular surveillance of antimicrobial resistance, and prudent use of drugs are suggested.…”
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