Modern potentials of prokinetics in treatment of gastroesophageal reflux disease by A. A. Sheptulin, V. A. Kiprianis

“…Nowadays proton pump inhibitors (PPI) are the basic drugs used in treatment of GERD. At the same time in last years cases of their inefficacy became frequent that can be caused by «night acid outbreak», and also non-acid refluxes. …”
Get full text

Exsanguinated to death by a perforated duodenal ulcer: Masquerader apprehended on autopsy by Priyanka Mishra, Nidhin Rehman, Suvradeep Mitra, Manoj G. Madakshira

“…The most prevalent etiology are Helicobacter pylori infection in 65%–70% and non-steroidal anti-inflammatory drugs (NSAIDS) abuse in 30%–50% cases depending on the prevalence of H. pylori infection. …”
Get full text

RETROSPECTIVE SENSITIVITY ANALYSIS OF KOCURIA SPP. TO ANTIBIOTICS by M.O. Faustova, O.A. Nazarchuk, G.A. Loban, Yu.V. Chumak, M.M. Ananieva, V.V. Bondarenko

“…Based on the cluster analysis of antibacterial drugs, according to the sensitivity of isolates of Kocuria spp. to them during 2019-2022, meropenem, benzylpenicillin, ceftazidime, cefotaxime, moxifloxacin, and ciprofloxacin with sensitivity higher than 50.0% were combined. …”
Get full text

Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo by Sura Akram, Ahmed Majeed Al-Shammari, Hayder B. Sahib, Majid Sakhi Jabir

“…Targeting cancer cells with selective and safe treatment seems like the best choice, as most chemotherapeutic drugs act unselectively. Papaverine showed promising antitumor activity with a high safety profile and increased blood flow through vasodilation. …”
Get full text

Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes by E. L. Mishchenko, V. A. Ivanisenko

“…Clinically tested vaccines are widely used to control rapidly spreading, acute, and often severe infections; however, effective drugs are still not available. The genomes of SARS-CoV-2 and SARS-CoV are approximately 80 % identical, while the genomes of SARS-CoV-2 and MERS-CoV are approximately 50 % identical. …”
Get full text

Fatal intoxication after oral ingestion of amphetamine: Two case reports by Evelyn Pawlik, Felix Mayer, Oliver Temme

“…Morphological findings and the toxicological results for (R-/S)- amphetamine, the amphetamine by-products, alcohol, other drugs and pharmaceuticals are shown for both cases. …”
Get full text

The Effects of Nigella Sativa (Black Seed) in Rhinosinusitis Subjects: A Systematic Review by Muhamad Najmi Muhamad Najemudin, Nurul Asyiqin Yusof

“…While various studies have reported Nigella Sativa's effects on rhinosinusitis, there is paucity in specifically addressing the optimal therapeutic dose and efficacy compared to conventional anti-histamine or anti-allergic drugs. Thus, this study aims to systematically review the effects of Nigella Sativa on rhinosinusitis in both human and animal subjects. …”
Get full text

The Role of PPARs in Lung Fibrosis by Heather F. Lakatos, Thomas H. Thatcher, R. Matthew Kottmann, Tatiana M. Garcia, Richard P. Phipps, Patricia J. Sime

“…PPARγ ligands, including the thiazolidinedione class of antidiabetic drugs, effectively inhibit lung fibrosis in vitro and in animal models. …”
Get full text

A Case of Carbamazepine-Induced Aggravation of Self-Limited Epilepsy with Centrotemporal Spikes Epilepsy and Valproate-Induced Hyperammonemic Encephalopathy in a Child with Heteroz... by Imalke Kankananarachchi, Eresha Jasinge, Gemunu Hewawitharana

“…Antiepileptics drugs are the mainstay of the management of epilepsy in children. …”
Get full text

Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice by Wenxian Dang, Rong Li, Jinyue Yang, Changhu Xue, Qingrong Huang, Yuming Wang, Tiantian Zhang

Get full text

A Fast and Validated HPLC Method for Simultaneous Determination of Dopamine, Dobutamine, Phentolamine, Furosemide, and Aminophylline in Infusion Samples and Injection Formulations by Fuchao Chen, Baoxia Fang, Sicen Wang

“…The new method has successfully been applied for quantification of all five drugs in their injection dosage form, infusion samples, and for evaluation of the stability of investigated drugs in mixtures for endovenous use. …”
Get full text

Hormones and Hormonal Anabolics: Residues in Animal Source Food, Potential Public Health Impacts, and Methods of Analysis by Belachew B. Hirpessa, Beyza H. Ulusoy, Canan Hecer

“…In order to fulfill the requirements, producers are using veterinary drugs such as hormones and hormone-like anabolic agents. …”
Get full text

Current views on etiology, diagnosis, epidemiology and gene therapy of maturity onset diabetes in the young by Lilya U. Dzhemileva, Elena N. Zakharova, Anna O. Goncharenko, Maria V. Vorontsova, S. A. Rumyantsev, Natalia G. Mokrysheva, Marina Y. Loguinova, Vladimir P. Chekhonin

“…The most commonly prescribed drugs for the treatment of hyperglycemia are sulfonylurea derivatives. …”
Get full text

Access to weight reduction interventions for overweight and obese patients in UK primary care: population-based cohort study by Martin C Gulliford, A Toby Prevost, Helen P Booth

“…In morbid obesity, rates of intervention per 1000 patient years were: advice, 60.2 (95% CI 51.8 to 70.4); referral, 75.7 (95% CI 69.5 to 82.6) and antiobesity drugs 89.9 (95% CI 85.0 to 95.2). Weight management interventions were more often accessed by women, older patients, those with comorbidity and those in deprivation. …”
Get full text

Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NF-κB Signaling Pathway following Stimulation... by Junchao Huang, Jialiang Lin, Congbin Li, Bo Tang, Haijun Xiao

“…The commonly used clinical treatment methods, such as nonsteroidal anti-inflammatory drugs and radiotherapy, have relatively large side effects, and more efficient treatment methods are needed in clinical practice. …”
Get full text

Immunoassay–mass spectrometry to identify Brucella melitensis by Amirreza Sharif, Ramin Bagheri Nejad, Alireza Ghassempour

Get full text

Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

“…Recent studies have demonstrated that chemotherapy drugs can mitigate the suppressive impact of TME, eliminate the physical barrier by destroying the tumor stroma, and facilitate greater penetration of immune cells and CAR-T cells into the tumor. …”
Get full text

The Impact of Anti-Diabetics on Platelets Function and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: A Narrative Review by Muthanna Zaki, Mohammed Abed, Fawaz Alassaf

“…This review aimed to explore the possible mechanistic association between anti-diabetic agents and the development of thromboembolic disorders, considering the effect of drugs on platelet function and their impact on cardiovascular outcomes in diabetic patients. …”
Get full text

Folk Medicine, Folk Healing by Mustafa SEVER

“…This person has the power of identifying and curing the diseases, disorders, consequently the origin of these diseases and disorders, and the skill of using various drugs for the treatment of the diseases and disorders or applying the practices with the help of information and practices acquired from the tradition. …”
Get full text

PHARMACEUTICAL GELS by Syeda Yamna Zia

“…They are non-invasive, less greasy, non-toxic, and inert to food and drugs. They have minimum side effects, hence becoming a reason for increasing patient compliance and topic of interest over the last few decades. …”
Get full text