A Child with Severe Malaria Presenting with Acute Surgical Abdomen (Duodenal Perforation) by Tika Ram Bhandari, Sudha Shahi, Rajesh Poudel, Nagendra Chaudhary

“…Here, we report a case of a 5-year-old male child with falciparum malaria complicated by a duodenal perforation that was successively managed with appropriate antimalarial drugs and early surgical repair.…”
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Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up by Jácome Bruges-Armas, Bruno F. Bettencourt, Ana R. Couto, Manuela Lima, Ana M. Rodrigues, Nathan Vastesaeger, Matthew A. Brown

“…Both patients were resistant to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Both patients were treated with infliximab, a TNF-α receptor antagonist, for nine years. …”
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Fungal Malignant Otitis Externa with Facial Nerve Palsy: Tissue Biopsy Aids Diagnosis by Jenny Walton, Chris Coulson

“…Diagnosis is often delayed due to the low sensitivity of aural swabs and many antifungal drugs have significant side effects. We present a case of FMOE, where formal tissue sampling revealed the diagnosis and the patient was successfully treated with voriconazole, in addition to an up to date review of the current literature. …”
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Towards Point-of-Care Diagnostic and Staging Tools for Human African Trypanosomiaisis by Enock Matovu, Anne Juliet Kazibwe, Claire Mack Mugasa, Joseph Mathu Ndungu, Zablon Kithingi Njiru

“…Control of this disease almost exclusively relies on chemotherapy that should be driven by accurate diagnosis, given the unacceptable toxicity of the few available drugs. Unfortunately, the available diagnostics are characterised by low sensitivities due to the inherent low parasitaemia in natural infections. …”
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Health information for the teenage years: what do they want to know? by J. Rolinson

“…What do they want to know? Sex 'n drugs 'n rock and roll? Reviewed are the information needs of adolescents within the educational setting, analyses of previous use and sources of Health Information and also the anticipated needs and preferred sources for the future. …”
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Eyelash Trichomegaly: Unusual Feature Associated with Systemic Lupus Erythematosus Patient by Amjad M. AlWarawreh, Ahmad M. AlWarawreh, Bashar F. Jarrar, Asem H. Aldebei, Mahasen S. Ajarmeh, Fadi F. Ayyash, Manal A. Abu Al-Ghanam

“…It may be linked to the use of certain drugs and can also be present as an isolated trait by birth. …”
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Pericardial Effusion due to Infliximab Therapy for Ulcerative Colitis by Muhammad Mirza, Maira Mirza, Vagishwari Murugesan, Arrel Olano

“…Antitumor necrosis factor alpha (anti-TNF alpha) agents such as infliximab are drugs that have been used for the treatment of ulcerative colitis for decades. …”
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Evaluation of Phenolic Content and Antioxidant Capacity of Eleusine coracana (L.) by Jignasu P. Mehta, Chirag R. Fultariya, Pravin H. Parmar, Solhil H. Vadia, Balubhai A. Golkiya

“…The antioxidant capacity of all phenolics was determined by rancimat study of sunflower oil using control and standard drugs like Glipizide and Metformin. The stability period of sunflower oil was found to increase from 0.89 hr to 1.04 hr in presence of eight extracted ingredients of Eleusine coracana (L.), which was compared with result of neat sunflower oil.…”
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Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome by Inge Heulens, Charlotte D'Hulst, Sien Braat, Liesbeth Rooms, R. Frank Kooy

“…Many drugs have been developed that are able to modulate the GABAergic system, which is involved in anxiety, depression, epilepsy, insomnia, and learning and memory. …”
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Investigating the neuroprotective effects of Dracocephalum moldavica extract and its effect on metabolomic profile of rat model of sporadic Alzheimer's disease by Marjan Talebi, Seyed Abdulmajid Ayatollahi, Mohammad Ali As’Habi, Farzad Kobarfard, Mona Khoramjouy, Farzaneh Niki Boroujeni, Mehrdad Faizi, Alireza Ghassempour

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Comparative Analysis In The Treatment Of Myocardial Infarcted Patients In The Tertiary Care Hospital Of Peshawar Against American Heart Association (ASA) Treatment Guidelines by Sher Afghan Khan, Qadeer Nawaz, Sameer Ahmad, Zainab Khattak, Sana Khan, Attiya Munir

“…The practicing doctors administered the drugs that were correct almost half decade ago but now new guidelines have overtaken them which leads to improved patients morbidity and decreased mortality. …”
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Prediction of influenza A virus-human protein-protein interactions using XGBoost with continuous and discontinuous amino acids information by Binghua Li, Xin Li, Xiaoyu Li, Li Wang, Jun Lu, Jia Wang

“…Identifying protein-protein interactions (PPIs) between IAV and human proteins is beneficial for understanding the mechanism of viral infection and designing antiviral drugs. In this article, we developed a sequence-based machine learning method for predicting PPI. …”
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Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study by Javier Enrique Cely, Elkin José Mendoza, Carlos Roberto Olivares, Oscar Julián Sepúlveda, Juan Sebastián Acosta, Rafael Andrés Barón, Juan José Diaztagle

“…The risk factors included CKD from stage 3 onwards, prehospital treatment with nephrotoxic drugs, and VTE at admission. EAKI is associated with prolonged hospital stay, increased mortality rate, and dialysis requirement.…”
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Evaluation of practices and attitudes of caregivers influencing adherence to seasonal malaria chemoprevention in children under five years of age: the case of Rural Embangweni, Mzi... by Chisomo Salangwa, Reston Munthali, Lusungu Mfune, Vegha Kaunga Nyirenda

“…SMC aims to administer a three-day course of anti-malarial drugs periodically during the months when malaria risk is highest. …”
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Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening mo... by Virginia Marugan-Hernandez, Javier Regidor-Cerrillo, Luis Ortega-Mora, Sara Arias-Maroto, Kelsilandia Aguiar-Martins

“…This disease is caused by protozoan parasites of the genus Eimeria (Apicomplexa), and it is mainly controlled by chemoprophylaxis with ionophores and chemical anticoccidials; however, there is an overall agreement about the limitation of these traditional drugs and the need to improve current methods of control. …”
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In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma by Yongfa Dai, Jing Li, Hong Wen, Jie Liu, Jianling Li

“…Our study provides a new perspective regarding the pathophysiological mechanism of APA and offers some small molecules that may possibly be effective drugs against APA.…”
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Effect of angiotensin-converting enzyme inhibitors versus that of angiotensin receptor blockers on survival in patients undergoing hemodialysis: a nationwide observational cohort s... by Seok Hui Kang, Gui Ok Kim, Bo Yeon Kim, Eun Jung Son, Jun Young Do

“…The patients were classified into four groups based on the use of renin-angiotensin system blockers (RASBs) as follows: No group, patients without a prescription of any anti-hypertensive drugs including RASBs; Other group, patients with a prescription of anti-hypertensive drugs excluding RASBs; ACEI group, patients with a prescription of an ACEI; and ARB group, patients with a prescription of an ARB.Results The 5-year survival rates in the no, other, ACEI, and ARB groups were 68.6%, 67.8%, 70.6%, and 69.2%, respectively. …”
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Smart phone-based transcutaneous electrical acupoint stimulation as adjunctive therapy for hypertension (STAT-H trial): protocol for a cluster randomised controlled trial by Yu Wang, Xiao Wang, Ying Lin, Chao-Qun Yan, Guang-Xia Shi, Cun-Zhi Liu, Jing-Wen Yang, Jian-Feng Tu, Shi-Yan Yan, Xin-Tong Su, Li-Qiong Wang, Si-Bo Kang, Bao-Hong Mi, He-Wen Li, Xue-Zhou Wang

“…Secondary outcomes will include the change of mean diastolic blood pressure, proportion of patients with controlled blood pressure (blood pressure <140/90 mm Hg), proportion of patients taking antihypertensive drugs, change in number of antihypertensive drugs and changes in 12-item Short-Form. …”
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The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis by Jaime Fernández-Sarmiento, Sushitra Ranjit, L. Nelson Sanchez-Pinto, Vinay M. Nadkarni, Roberto Jabornisky, Niranjan Kissoon

“…Fluid therapy and vasoactive drugs are cornerstone therapies for circulatory problems in sepsis. …”
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A novel high-throughput screen identifies phenazine-1-carboxylic acid as an inhibitor of African swine fever virus replication in primary porcine alveolar macrophages by Jing Lan, Rui Luo, Di Liu, Changxing Qi, Xin Song, Zhanhao Lu, Ruojia Huang, Yuying Yang, Yuan Sun, Yonghui Zhang, Tao Wang, Hua-Ji Qiu

“…To conduct high-throughput screening (HTS) for anti-ASFV drugs, we initially developed a recombinant dual-reporter virus (rASFV-Gluc/EGFP) using the virulent strain ASFV HLJ/18 (ASFV-WT). …”
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