An Uncommon Side Effect of Bupropion: A Case of Acute Generalized Exanthematous Pustulosis by Hasan Tak, Cengiz Koçak, Gülben Sarıcı, Nazlı Dizen Namdar, Mehtap Kıdır

“…Despite its similarity to pustular psoriasis and association with fever and leukocytosis, AGEP typically heals quickly. Etiologically, drugs and viruses have been suspected in most cases. …”
Get full text

Ventricular Tachycardia Induced by Weight Loss Pills by Manan Pareek, Nils Henrik Hansson, Erik Lerkevang Grove

“…In particular, ephedrine-containing drugs carry a risk of ventricular tachycardia and should be discouraged.…”
Get full text

The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies by Liu S, Zhang G, Li N, Wang Z, Lu L

“…Current therapeutic strategies primarily focus on anti-inflammatory agents such as non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, with growing interest in anti-senescence drugs targeting cellular senescence and SASP. …”
Get full text

Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation by Chao-Yang Lai, Yu-Wen Su, Kuo-I Lin, Li-Chung Hsu, Tsung-Hsien Chuang

“…Therefore, they represent candidate psoriasis drugs and might lead to the development of new treatment options.…”
Get full text

Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer by Sakshi Sikka, Luxi Chen, Gautam Sethi, Alan Prem Kumar

“…These TZD-derived novel therapeutic agents, alone or in combination with other anticancer drugs, have translational relevance in fostering effective strategies for cancer treatment. …”
Get full text

Sirolimus Enhances Cyclosporine A-Induced Cytotoxicity in Human Renal Glomerular Mesangial Cells by Séin O'Connell, Craig Slattery, Michael P. Ryan, Tara McMorrow

“…These synergistic alterations may have been due to an increase in CTGF which was not evident when the immunosuppressive drugs were used alone. The CsA/SRL combination therapy significantly enhanced Smad signalling and altered the extracellular matrix regulator matrix metalloproteinase 9 (MMP-9). …”
Get full text

Corneal Opacity Induced by Antiglaucoma Agents Other Than Brimonidine Tartrate by Yuka Kasuya, Ichiya Sano, Shinji Makino, Hidetoshi Kawashima

“…Anterior-segment optical coherence tomography (OCT) showed marked corneal opacity and thickened corneal stroma. The topical drugs were discontinued and replaced with 0.1% betamethasone eye drops. …”
Get full text

Selective mPGES-1 Inhibitor Ameliorated Adjuvant-Induced Arthritis in the Rat Model by Min Ji Kim, Hwi-Ho Lee, Choi Kim, Ja Yeon Lee, Kyung-Sook Chung, Kyung-Tae Lee, Jae Yeol Lee

“…Among them, mPGES-1 is regarded as a more promising ideal target for anti-inflammatory drugs without the gastrointestinal and cardiovascular side effects. …”
Get full text

Reaction of the Liver upon Long-Term Treatment of Fluoxetine and Atorvastatin Compared with Alcohol in a Mouse Model by Zhiliang Chen, Tony C. H. Chow, Shicong Wang, Gigi C. T. Leung, Sharon L. Y. Wu, David T. Yew

“…In this study, we investigated the effects of the drugs fluoxetine and atorvastatin on the liver and compared with those of alcohol in a mouse model. …”
Get full text

Correlation between blood pressure control status and cognitive impairment in older adults: A national cross-sectional study. by Junxiu Yao, Shengshu Wang, Meiling Li, Baomei Song, Cong Lan, Jianjun Jia, Yongjian Yang

“…There was a significant correlation between hypotension and cognitive impairment, and no correlation between hypertension and cognitive impairment in people aged ≥ 80 years, Han ethnicity and those who used antihypertensive drugs. Furthermore, RCS model analysis showed that there was a non-linear relationship between systolic blood pressure and cognitive impairment in individuals aged ≥ 80 years and those using antihypertensive drugs. …”
Get full text

Efficacy of Topical Corticosteroid Monotherapy in Inducing and Maintaining Clinical and Histologic Remission in Adolescent and Adult Patients with Eosinophilic Esophagitis: a Syste... by A. A. Makushina, O. A. Storonova, A. S. Trukhmanov, T. L. Lapina, V. T. Ivashkin

“…Topical steroids represent a promising group of drugs for inducing and maintaining clinical and histological remission in these patients.Objective. …”
Get full text

Antiasthmatic Medicinal Plants of Tanzania: An Ethnomedicinal and Ethnopharmacological Review by David Sylvester Kacholi

“…Traditional medicinal plants (TMPs) are a significant part of people’s quality of life, offering a natural substitute for modern drugs with numerous side effects. In Tanzania, data on antiasthmatic TMPs are highly fragmented. …”
Get full text

Cuproptosis-related lncRNAs and genes: Potential markers for glioblastoma prognosis and treatment. by Yajia Chen, Jingxian Zhang, Weiqian Zheng, Hongwu Xu

“…Interestingly, normal astrocytes were less sensitive than GBM cells to cuproptosis-inducing drugs, and the effects of the drugs on the expression of the CRLs and CRGs in normal astrocytes were opposite to that of in GBM cells. …”
Get full text

A narrative review of long-term inorganic iodine monotherapy for Graves’ disease with a historical relationship between iodine and thyroid by Natsuko Watanabe

“…Since there were concerns about the escape phenomenon and exacerbation with inorganic iodine, antithyroid drugs became the mainstay of pharmacotherapy for Graves’ disease following their development in the 1940s. …”
Get full text

Impact of Mouthwash-Induced Oral Microbiome Disruption on Alzheimer's Disease Risk: A Perspective Review by Ayoub Boulares, Hela Jdidi, Nicola Luigi Bragazzi

Get full text

Prediction of traditional Chinese medicine for diabetes based on the multi-source ensemble method by Bin Yang, Qingyun Chi, Xiang Li, Jinglong Wang

“…Finally, the frequencies of occurrences of the medicinal herbs obtained from the three algorithms using the component and target datasets are integrated to select duplicate drugs as the candidate drugs for diabetes treatment.ResultsThe identification results reveal that theproposed ensemble method has higher accuracy than GBDT, FNT, and LightGBM. …”
Get full text

Etiology and epizootology of bovine mastitis (analytical review) by A. A. Andreeva, V. A. Evgrafova, M. S. Voronina, O. V. Pruntova, N. B. Shadrova

“…Due to the widespread spread of antibiotic-resistant microorganism strains, despite the large number of drugs currently used, their effectiveness is constantly decreasing. …”
Get full text

Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents by Tulika Anthwal, Swati Pant, Preeti Rana, Sumitra Nain

“…Similarly, the standard drugs also displayed no neurotoxicity at the highest dose (300 mg/kg). …”
Get full text

Pretreatment with Low-Dose Esketamine for Reduction of Propofol Injection Pain: A Randomized Controlled Trial by Danyun Fu, Dingding Wang, Wenxian Li, Yuan Han, Jie Jia

“…The secondary outcomes included injection pain score, vital signs, total dosage of vasoactive drugs used within 5 minutes after induction, and adverse events related to drugs. …”
Get full text

The Anticonvulsant Enaminone E139 Attenuates Paclitaxel-Induced Neuropathic Pain in Rodents by Dhandapani Thangamani, Ivan Ogheneochuko Edafiogho, Willias Masocha

“…It has been reported to have a better safety profile than some anticonvulsant drugs. Since some anticonvulsant drugs are used in the management of neuropathic pain, we evaluated the effects of E139 in rodent models of acute pain and paclitaxel-induced neuropathic pain. …”
Get full text